Breast-conserving surgery following radiation therapy of 50 Gy in Stages I and II carcinoma of the breast: The experience at one institute in Japan

Horiguchi, Jun; Koibuchi, Yukio; Takei, Hiroyuki; Yokoe, Takao; Yamakawa, Michitaka; Nakajima, Takashi; Oyama, Tetsunari; Iino, Yuichi; Morishita, Yasuo

doi:10.3892/or.9.5.1053

Cited by 7 publications

(6 citation statements)

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“…Lack of an association between the tumour margin and hormone receptor status was reported in a study conducted on 254 patients undergoing partial mastectomy [35]. Similarly, Horiguchi et al [31,33] found no association with tumour expression of ER.…”

Section: Discussionmentioning

confidence: 94%

“…Irregular (stellate) margins did not associate with PgR expression. An association between the tumour margin status and Her-2, ER, or PgR expression has been investigated in several studies [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. Putti et al [29] recently demonstrated that breast tumours with a pushing margin (another terminology for irregular or stellate margin) were found to be ER negative and over expressing Her-2.…”

Section: Discussionmentioning

confidence: 99%

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Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis

Saleh¹,

Abdeen²

2008

European Journal of Cancer Supplements

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis

Saleh¹,

Abdeen²

2008

European Journal of Cancer Supplements

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“…Lack of an association between the tumour margin and hormone receptor status was reported in a study conducted on 254 patients undergoing partial mastectomy [ 35 ]. Similarly, Horiguchi et al [ 31 , 33 ] found no association with tumour expression of ER.…”

Section: Discussionmentioning

confidence: 94%

Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis

Saleh¹,

Abdeen²

2007

Journal of Carcinogenesis

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BackgroundBreast cancer accounts for 30.3% of all cancer types in Kuwaiti women. Death occurs in approximately 43% of these patients. Our goal was to conduct a comprehensive analysis of the pathobiological characteristics of the tumours in an attempt to determine any particular trend that could be present.MethodsOne hundred and sixty-six cases were included in this study. All the pathology reports and paraffin blocks pertaining to these cases were collected. Four micrometer sections were taken from each block, and immunostaining against Her-2, ER, and PgR was performed. Both the proportion and intensity of immunostaining were scored according to the Allred's method, and typing of the tumour was done according the WHO criteria regarding tumour classification. Grading of invasive carcinomas was done according to the modified Bloom-Richardson-Elston's method, and tumour stage was determined according to the criteria set by the American Joint Committee on Cancer.ResultsThe mean age of the patients below 55 years was 40, as compared to 68 for those above 55 (p < 0.0001). More than half of the cases were in the right breast, and were surgically treated by total mastectomy with axillary clearance. The majority of the tumours had irregular (stellate) margins, was invasive, and had a surrounding breast tissue of adenosis or fibrocystic type. Their mitotic index was 10–20 or >20 with a marked to moderate nuclear pleomorphism. They were mostly grade II or III, sized 2–5 or > 5 cm, had absent or scanty tumour lymphocytes, and were stage II or III. The in situ tumours were mainly ductal carcinoma (DCIS) of which comedo and cribriform were the major histological subtypes. The major histological subtypes of the invasive tumours were ductal-not otherwise specified, lobular, and tubular/cribriform. In this study, we also found a significant (p < 0.05) association between over expression of Her-2, lack of expression of ER and some of the characteristics mentioned above.ConclusionBreast cancer in Kuwait seems to be more aggressive than what is currently seen in Europe, North America, Australia, and parts of Asia. Further investigations regarding the features observed in this study need to be performed.

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“…In 1999 Peterson showed LRRs of 8%, 10%, and 17%, respectively, for negative, focally positive, and focally close (≤2 mm) margins from a series of consecutive 1021 stage I or II breast malignancies [8]. A strong correlation between local recurrence rates and margins status has been demonstrated in a large number of other studies based on follow-up after breast-conserving surgery plus local radiotherapy [9–14], but the adequacy of microscopic margins width remains controversial. Horiguchi has reported 7 local recurrences in a series of 217 breast cancers (3.2%) treated with BCS following a 50 Gy radiation therapy, while Karasawa reported in a retrospective analysis of 348 patients who underwent BCS an LRR of 1.7%.…”

Section: What Is An Adequate Surgical Margin?mentioning

confidence: 99%

“…Horiguchi has reported 7 local recurrences in a series of 217 breast cancers (3.2%) treated with BCS following a 50 Gy radiation therapy, while Karasawa reported in a retrospective analysis of 348 patients who underwent BCS an LRR of 1.7%. Both of these studies considered negative SM width of 5 mm, and Horiguchi identified the microscopic SM as an independent predictive factor for local recurrence in the conserved breast [9, 10]. …”

Section: What Is An Adequate Surgical Margin?mentioning

confidence: 99%

Preoperative Localization and Surgical Margins in Conservative Breast Surgery

Corsi

Sorrentino

Bossi

et al. 2013

International Journal of Surgical Oncology

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Breast-conserving surgery (BCS) is the treatment of choice for early breast cancer. The adequacy of surgical margins (SM) is a crucial issue for adjusting the volume of excision and for avoiding local recurrences, although the precise definition of an adequate margins width remains controversial. Moreover, other factors such as the biological behaviour of the tumor and subsequent proper systemic therapies may influence the local recurrence rate (LRR). However, a successful BCS requires preoperative localization techniques or margin assessment techniques. Carbon marking, wire-guided, biopsy clips, radio-guided, ultrasound-guided, frozen section analysis, imprint cytology, and cavity shave margins are commonly used, but from the literature review, no single technique proved to be better among the various ones. Thus, an association of two or more methods could result in a decrease in rates of involved margins. Each institute should adopt its most congenial techniques, based on the senologic equipe experience, skills, and technologies.

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Breast-conserving surgery following radiation therapy of 50 Gy in Stages I and II carcinoma of the breast: The experience at one institute in Japan

Cited by 7 publications

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Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis

Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis

Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis

Preoperative Localization and Surgical Margins in Conservative Breast Surgery

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