Breast Carcinoma in Association with the Klinefelter’s Syndrome

Scheike, Ole; Visfeldt, Jakob; Petersen, Bent

doi:10.1007/978-3-642-69644-2_16

Cited by 5 publications

(5 citation statements)

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“…In ten cases it was located in the right breast, in two cases in the left, in one case it was bilateral and in one case the location was not stated. Its right-sided predominance is statistically significant (P < 0.05), as well as peculiar (Scheike et al 1973) (our patient was affected in the 'left side).…”

Section: Dermatoglyphicssupporting

confidence: 45%

“…Collection of these series revealed that 9 out of 242 male patients with breast cancer were chromatin positive, which is a higher incidence than that found in the normal male population. On the basis of the incidence of breast cancer in women and men, and the incidence of sex chromatin-positive individuals in the normal male population, the incidence of breast cancer among patients with Klinefelter syndrome was found to be about one-fifth of the incidence of breast cancer in women, and about 20 times that of breast cancer in normal men (Scheike et al 1973).…”

Section: Dermatoglyphicsmentioning

confidence: 99%

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XX Male with breast cancer

et al. 1980

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We present the case of a 66‐year‐old XX male who developed breast cancer on the left side at the age of 61. His clinical, endocrinological and cytogenetic features are described. The presence of hypospadias and cancer in the left breast are noteworthy; the latter is very rarely found in Klinefelter syndrome patients. An outline of the pathogenesis of breast cancer in XX male patients is also given. This is the first report of an XX male with breast cancer.

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Section: Dermatoglyphicssupporting

confidence: 45%

Section: Dermatoglyphicsmentioning

confidence: 99%

XX Male with breast cancer

et al. 1980

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“…The frequency of malignancies (which may eventually lead also to sexual precocity) appears to be elevated in Klinefelter syndrome. Thus, an increased incidence of carcinoma of the breast [16] and of leukaemia [12] have been observed. In five patients reported in the literature, pubertas praecox was due to hormonally active intrathoracic teratomas [1, 4,5,6,7,11,14], three of them were malignant [1, 6,7,11].…”

Section: Discussionmentioning

confidence: 96%

Sexual precocity in klinefelter syndrome: report on two new cases with idiopathic central precocious puberty

Mühlendahl

Heinrich

1994

Eur J Pediatr

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“…From the British cohort, a study concerning cancer-specific mortality and cancer incidence (8) showed a nonsignificant increase in overall cancer mortality, SMR 1.2 (95% CI 1.0-1.4, p = 0.13), but significantly increased risk of dying from breast cancer, SMR 57.8 (18.8-135.0), lung cancer, SMR 1.5 (1.0-2.0) and non-Hodgkin lymphoma, SMR 3.5 (1.6-6.6), but a significantly reduced risk of dying from prostate cancer, SMR 0.0 (0.0-0.7). Several case reports have also emphasized the increased risk of breast cancer (24,25), mediastinal germ cell cancer (26) and perhaps also other cancer types.…”

Section: Studies Regarding Cancer In Ksmentioning

confidence: 99%