Breast carcinoma after cancer therapy in childhood

Abstract

Among 910 survivors of childhood cancer, four developed infiltrating carcinoma of the breast and another had noninfiltrating breast tumor. Expected frequency was 0.3 cases of breast cancer in the series. The affected women developed breast carcinoma at ages 20, 25 and 38 years, and the men at ages 38 and 39 years, respectively. Each patient had received orthovoltage chest irradiation for treatment of Wilms' tumor or bone sarcoma between seven and 34 years previously, and estimated radiation dose to the breast exceeded 300 rad in each instance. Four patients also received diverse forms of chemotherapy. Survivors of childhood cancer have increased risk of developing breast cancer and should undergo periodic screening, particularly after breast tissue had been irradiated. Individualized radiotherapy planning can help exclude the breasts from treatment fields for some thoracic neoplasms.

Breast Cancer Risk 55+ Years After Irradiation for an Enlarged Thymus and Its Implications for Early Childhood Medical Irradiation Today

“…As previously mentioned, the higher breast doses in the thymus cohort overlap with exposures to the breast from current radiotherapy protocols for childhood Hodgkin's lymphoma, while lower doses may be consistent with scatter from treatment for other malignancies such as Wilms tumor (14, 53). More importantly the lower doses in this cohort are similar to those to the breast of infants from chest CT.…”

Radiation dose and breast cancer risk in patients treated for cancer of the cervix

“…The breast is not only the most common site of cancer among women, it is also one of the tissues most susceptible to radiation-induced cancer. Excess breast cancers have been reported in surveys of tuberculosis patients who had received multiple fluoroscopic examinations of the chest (Boice and Monson, 1977;Howe, 1984;Hrubec et al, 1989); mastitis patients given radiotherapy (Shore et al, 1986); atomic bomb survivors (Tokunaga et al, 1987); children given radiotherapy for cancer (Li et al, 1983), enlarged thymus glands (Hildreth et al, 1985), or skin hemangioma (Fiirst et al, 1988); women treated with radiation for Hodgkin's disease (Curtis and Boice, 1988), breast cancer (Hankey et al, 1983), benign breast disorders (Baral et al, 1977), or ankylosing spondylitis (Darby et al, 1987); X-ray workers in China (Wang et al, 1988); and women working with radium (luminous paint) in the watch Trend: p = 0.10 (1-sided) 'Reference category: women with cervical cancer not given radiotherapy.-*Both ovaries were removed prior to or within 1 year after cervical cancer diagn~sis.-~Adjusted for time since diagnosis of cervical cancer, calendar year of diagnosis, and ~enter.-~For one control who received low-dose radiotherapy, the resulting dose to the breast was estimated to be less than 0.01 Gy.…”

Serum Lipid Profile of Breast Cancer Patients in Kashmir

“…Breast cancer primarily affects women with occasional incidence in men and female to male ratio of breast cancer prevalence is reported to be 100:1 [1].The aetiology of the disease is unknown, although both low radiation and oncogenic viruses may play a role. A variety of interrelated hormonal, genetic, environmental, and physiological factors exert an influence on the development of this disease [3][4]. Despite the identification of high risk factors, only 35% of breast cancer can explained by known or suspected risk factors, including modifiable behaviours involving diet, overweight, and exercise and alcohol use [4].…”