Serum Lipid Profile of Breast Cancer Patients in Kashmir

Abstract

Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. The aim of this study was to carry out a comparative study to investigate the effect of lipid profile, oestradiol (EST) and obesity on the risk of a woman developing breast cancer. In this study, 120 women including 60 breast cancer patients (25 to 80 years) were assessed for lipid profile, EST and Body Mass Index (BMI) and 60 controls with similar age range. There was a significant increase in Body Mass Index (BMI) (p = 0.011), Total Cholesterol (TC) (p<0.001), triglyceride (p = 0.026) and low density lipoprotein (LDLcholesterol) (p = 0.001) of the breast cancer patients compared to the controls. With the exception of EST that decreased, the lipid profile generally (TG) increased with age in both subjects and controls with the subjects having a much higher value than the control taken in the study. There was also a significant positive correlation between BMI and TC (r 2 = 0.022; p = 0.002) and also between BMI and LDL-cholesterol (r 2 = 0.031; p = 0.0003). Apart from EST and LDL-cholesterol that were increased significantly only in the postmenopausal phase in comparison to the controls, BMI, TC and TG were increased in both pre-menopausal and post menopausal phases with HDL-cholesterol remaining unchanged. This study confirms the association between lipid profile, BMI and increased breast cancer risk.

Evaluation of Serum Lipids and C-peptide among Breast Cancer Patients with Chemotherapy

“…We found increased level of serum TC in both pre and postmenopausal breast cancer patients as compared to their respective control group. Our findings were in accordance to the several other studies [18][19][20][21].An increased level of TC was observed in breast cancer patients on chemotherapy as compared to control but the differences were not statistically significant [9,26].In contrast to our finding, a study by Timovska et al found decreased level of serum total cholesterol after two courses of neoadjuvant chemotherapy [22].In the present study, we observed decreased HDL-cholesterol level in breast cancer patient but the difference was statistically non significant as compared tocontrol group. The previous studies conducted on breast cancer patients reported unchanged or slightly decreased HDLcholesterol level in breast cancer patients as compared to control group [9,20,21].…”

“…Our findings were in accordance to the several other studies [18][19][20][21].An increased level of TC was observed in breast cancer patients on chemotherapy as compared to control but the differences were not statistically significant [9,26].In contrast to our finding, a study by Timovska et al found decreased level of serum total cholesterol after two courses of neoadjuvant chemotherapy [22].In the present study, we observed decreased HDL-cholesterol level in breast cancer patient but the difference was statistically non significant as compared tocontrol group. The previous studies conducted on breast cancer patients reported unchanged or slightly decreased HDLcholesterol level in breast cancer patients as compared to control group [9,20,21]. A few other studies reported significantly decreased HDL-cholesterol level in breast cancer patients [18,23,26].In contradict to our study; Peela et alfound significantly increased level of HDLcholesterol in breast cancer patients as compared to control [19].…”

“…Non-HDL cholesterol includes low density lipoprotein cholesterol(LDL), very low density lipoprotein cholesterol (VLDL) and all other forms of bad cholesterol. Different studies observed LDLcholesterol level was found to be elevated in breast cancer patients than the control [14,20,21,23].A prospective study by Santos et alreported LDL-cholesterol is highly associated with breast cancer progression and the patients with high levels of LDL-cholesterol have reduced chance to survive disease free [15]. A study by Nwozo et al found no significant difference in LDL-cholesterol level in breast cancer patients on chemotherapy as compared to control [9].…”

A Comparitive Study to Evaluate the Role of Serum Lipid Levels in Aetiology of Carcinoma Breast

“…They found significant increase in BMI, Total Cholesterol, triglyceride and low density lipoprotein (LDL-cholesterol) in the breast cancer patients as compared to the controls. BMI, TC and TG were increased in both pre-menopausal and post menopausal cases with HDL-cholesterol remaining unchanged [16]. Laisupasin et al, studied a total of 403 women.…”

A case-control study of the lipid profile of women with breast cancer

“…Similar results were obtained by Peela et al, [31], and in a Danish study, demonstrating a statistically insignificant negative correlation between TG and breast cancer. Several other studies demonstrated a significant increase in TG value in patients with breast cancer [22,24,31,32]. Preventing the rise of cholesterol levels, both by limiting its availability and reducing its intracellular synthesis, might inhibit tumour growth and prevent carcinogenesis [33].…”