Breast cancer survival and the expression of genes related to alcohol drinking

Abstract

Breast cancer is the leading cause of cancer-related disease in women. Cumulative evidence supports a causal role of alcohol intake and breast cancer incidence. In this study, we explore the change on expression of genes involved in the biological pathways through which alcohol has been hypothesized to impact breast cancer risk, to shed new insights on possible mechanisms affecting the survival of breast cancer patients. Here, we performed differential expression analysis at individual genes and gene set levels, respectively, across survival and breast cancer subtype data. Information about postdiagnosis breast cancer survival was obtained from 1977 Caucasian female participants in the Molecular Taxonomy of Breast Cancer International Consortium. Expression of 16 genes that have been linked in the literature to the hypothesized alcohol-breast cancer pathways, were examined. We found that the expression of 9 out of 16 genes under study were associated with cancer survival within the first 4 years of diagnosis. Results from gene set analysis confirmed a significant differential expression of these genes as a whole too. Although alcohol consumption is not analyzed, nor available for this dataset, we believe that further study on these genes could provide important information for clinical recommendations about potential impact of alcohol drinking on breast cancer survival.

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“…Alcohol intake, even less than 10–50 g per day, induces an increased risk of this disease. The European Prospective Investigation into Cancer and Nutrition (EPIC) demonstrated a strong association between alcohol consumption and BC risk in ER+ tumors (N = 360,000 from 10 countries in Europe) [ 59 , 60 , 61 , 62 ]. Ethanol intake increases endogenous E levels, especially estradiol and estrone [ 63 ].…”