Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study

Wright, Lauren B.; Schoemaker, Minouk J.; Jones, Michael E.; Ashworth, Alan; Swerdlow, Anthony

doi:10.1002/ijc.31364

Cited by 14 publications

(21 citation statements)

References 52 publications

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“…Some studies, including the aforementioned Norwegian study found no association between hyperemesis and risk of breast cancer (80,81). Other studies report an increased risk of breast cancer subsequent to hyperemesis (82,83).…”

Section: Autoimmune Diseasementioning

confidence: 97%

Cardiovascular risk profile at the age of 40–45 in women with previous hyperemesis gravidarum or hypertensive disorders in pregnancy: A population-based study

Fossum

Halvorsen

Vikanes

et al. 2018

Pregnancy Hypertension

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Section: Autoimmune Diseasementioning

confidence: 97%

Cardiovascular risk profile at the age of 40–45 in women with previous hyperemesis gravidarum or hypertensive disorders in pregnancy: A population-based study

Fossum

Halvorsen

Vikanes

et al. 2018

Pregnancy Hypertension

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show abstract

“…In the Generations Study, the association between preeclampsia and breast cancer risk did not vary among women with and without in utero exposure to preeclampsia. 29 Study strengths include the large sample size and prospective design, which is expected to limit differential recall of gestational hypertensive disorders by breast cancer status. The size and diversity of our cohort enabled us to stratify by demographic, lifestyle, pregnancy, and breast cancer characteristics, although we acknowledge reduced precision in some strata.…”

Section: Discussionmentioning

confidence: 99%

Gestational Hypertensive Disorders and Maternal Breast Cancer Risk in a Nationwide Cohort of 40,720 Parous Women

et al. 2022

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Background: Preeclampsia and gestational hypertension are hypothesized to be associated with reduced maternal breast cancer risk, but the epidemiologic evidence is inconclusive. Our objective was to examine associations between gestational hypertensive disorders and breast cancer in a nationwide cohort of women with a family history of breast cancer. Methods: Women ages 35-74 years who had a sister previously diagnosed with breast cancer, but had never had breast cancer themselves, were enrolled in the Sister Study from 2003 to 2009 (N = 50,884). At enrollment, participants reported diagnoses of eclampsia, preeclampsia, or gestational hypertension in each pregnancy. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between history of a gestational hypertensive disorder and incident invasive breast cancer or ductal carcinoma in situ among 40,720 parous women. We used age as the time scale and adjusted for birth cohort, race-ethnicity, and reproductive, socioeconomic, and behavioral factors. We examined effect measure modification by risk factors for gestational hypertensive disease and breast cancer and assessed possible etiologic heterogeneity across tumor characteristics. Results:The prevalence of gestational hypertensive disease was 12%. During follow-up (mean = 10.9 years), 3,198 eligible women self-reported a breast cancer diagnosis. History of a gestational hypertensive disorder was not associated with breast cancer risk (HR = 1.0; 95% CI = 0.90, 1.1). We did not observe clear evidence of effect measure modification or etiologic heterogeneity. Conclusions: History of a gestational hypertensive disorder was not associated with breast cancer risk in a cohort of women with a firstdegree family history of breast cancer.

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“…On the other hand, a decrease in the insulin-like growth factor in this complication may also play a role in this hypothesis. A number of studies have confirmed the link between breast cancer and preeclampsia (65)(66)(67).…”

Section: Preeclampsiamentioning

confidence: 97%

Breast Cancer and Ways to Diagnose the Risk Factors and Treat it During Pregnancy: A Narrative Review

Ghamari¹,

Ghaderi²,

Moghaddam³

et al. 2020

International Journal of Women’s Health and Reproduction Scienc

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IntroductionBreast cancer is a type of cancer that starts in the breast tissue and can spread to other nearby tissues in addition to affecting the entire breast tissue (1). It is the most common cancer worldwide, causing extensive mortality and many complications (2-4). The incidence of breast cancer is globally increasing, especially in developing countries. Notably, about 6 million women with breast cancer were globally identified during 2008-2013 (5). More than 255 000 new cases of breast cancer occurred in the United States in 2017. Meanwhile, the annual incidence of breast cancer is 33 cases per 100 000 people in Iran, and the highest rate has occurred in Tehran, Isfahan, Yazd, Markazi, and Fars provinces (6).One of the concerns associated with breast cancer is its experience during pregnancy (7). Pregnancy-associated breast cancer refers to cancer that occurs during pregnancy, breastfeeding, or one year after delivery. It is the second most common cancer in pregnancy, which rarely occurs and does not cause many deaths (8,9). Diagnostic and therapeutic interventions during this period are implemented with special considerations. Women with breast cancer are clearly at a more advanced stage of the disease during pregnancy and usually have a poorer prognosis (10,11). One of the major challenges in diagnosis and treatment during this period is maintaining a balance in the aggressive care of these patients and appropriate treatments to maintain the health of the fetus/ baby. Given that the occurrence of this cancer during pregnancy can have adverse effects on the health of the mother, the baby, and the fetus, the current study aimed to investigate the factors affecting the incidence of this type of cancer during pregnancy. Materials and MethodsThis review study aimed at evaluating the relationship between pregnancy-related variables and the risk of breast cancer. This article review focused on all studies performed in this field until 2019. The related studies were selected from Persian and English databases. Iranian databases included SID, Irandoc, and Magiran, and English databases included PubMed, Scopus, Science Direct, Cochrane, Google Scholar, and Embase. Keywords were based on Mesh, including breast cancer and pregnancy. The inclusion criterion was accessing the full text of the articles, and the exclusion criterion was conference papers and articles, full-text versions of which were unavailable. ResultsIn general, 161 articles were found in the first stage although they were excluded from the review process at different stages and for scientific reasons. Finally, 83

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Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study

Cited by 14 publications

References 52 publications

Cardiovascular risk profile at the age of 40–45 in women with previous hyperemesis gravidarum or hypertensive disorders in pregnancy: A population-based study

Cardiovascular risk profile at the age of 40–45 in women with previous hyperemesis gravidarum or hypertensive disorders in pregnancy: A population-based study

Gestational Hypertensive Disorders and Maternal Breast Cancer Risk in a Nationwide Cohort of 40,720 Parous Women

Breast Cancer and Ways to Diagnose the Risk Factors and Treat it During Pregnancy: A Narrative Review

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