Breast cancer risk based on adapted IBIS prediction model in Slovenian women aged 40–49 years - could it be better?

Oblak, Tjasa; Zadnik, Vesna; Krajc, Mateja; Lokar, Katarina; Žgajnar, Janez

doi:10.2478/raon-2020-0040

Cited by 3 publications

(5 citation statements)

References 24 publications

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“…And the incidence of BC in France is the highest in Europe (Sancho-Garnier and Colonna, 2019). In Asian countries, the incidence rate of BC has also been increasing rapidly (Mubarik et al, 2020;Oblak et al, 2020). The pathogenesis of BC is multifactorial.…”

Section: Introductionmentioning

confidence: 99%

Association of Interleukin-10 Polymorphism (rs1800896, rs1800871, and rs1800872) With Breast Cancer Risk: An Updated Meta-Analysis Based on Different Ethnic Groups

Xiong

et al. 2022

Front. Genet.

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Background: The interleukin10 (IL-10) gene polymorphisms have been indicated to be associated with breast cancer (BC) risk, but the findings are still controversial. To derive a more precise evaluation, we performed a comprehensive meta-analysis.Methods: A systematic literature search was conducted using PubMed, Embase, CNKI, China biomedical (CBM), and Google Scholar to 29 March 2020. Revman5.3 and Stata 12.0 software analyzed the data, and the strength of the association was identified using the odds ratio (OR) and the corresponding 95% confidence interval (CI).Results: A total of 23 studies (7,250 cancer cases and 7,675 case-free controls) were included in this meta-analysis. The results show that IL-10 gene polymorphisms were significantly correlated with BC risk based on subgroup analysis by ethnicity. The IL-10 rs1800896 polymorphism was significantly associated with the risk of BC in Asians (G vs. A: OR = 0.78, 95% CI = 0.65–0.95, p = 0.01; GG vs. AA: OR = 0.51, 95% CI = 0.31–0.84, p = 0.007; GA vs. AA: OR = 0.6, 95% CI = 0.44–0.81, p = 0.0009; GG + GA vs. AA: OR = 0.6, 95% CI = 0.45–0.81, p = 0.0007); Moreover, an increased BC risk in Asians were also associated with the IL-10 rs1800872 polymorphism (AA vs CC: OR = 0.74, 95% CI = 0.55–0.99, p = 0.04; A vs C: OR = 0.85, 95% CI = 0.74–0.98, p = 0.03). In addition, The IL-10 rs1800871 (CT vs. TT: OR = 1.8, 95% CI = 1.03–3.13, p = 0.04) and rs1800872 polymorphism (A vs C: OR = 0.65, 95% CI 0.43–0.98, p = 0.04) were associated with BC risk in Caucasians.Conclusion: Collectively, this meta-analysis demonstrated that IL-10 rs1800896 and rs1800872 (AA vs. CC; A vs. C) polymorphisms significantly increased the risk of BC in Asians, while the rs1800871 and rs1800872 (A vs. C) were associated with the risk of BC in Caucasians. Therefore, this may provide new ideas for predicting and diagnosing BC susceptibility through the detection of IL-10 gene polymorphism.Systematic Review Registration: [https://www.crd.york.ac.uk/ PROSPERO], identifier [CRD42021266635].

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Section: Introductionmentioning

confidence: 99%

Association of Interleukin-10 Polymorphism (rs1800896, rs1800871, and rs1800872) With Breast Cancer Risk: An Updated Meta-Analysis Based on Different Ethnic Groups

Xiong

et al. 2022

Front. Genet.

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“…The study concluded, that inclusion of additional risk factors into the S-IBIS is needed to reliably stratify women into the BC risk groups. 32 …”

Section: Discussionmentioning

confidence: 99%

“…Some regional and hospital/breast cen- tres-based research have been conducted to assess women's BC risk. 19,25,31,32 Due to different subpopulations assessed and low sample volumes, the results of these studies cannot be directly compared to our study. They were all conducted among women referred to breast centres, where women with a positive family history or previous biopsies are normally assessed.…”

Section: Risk Stratification and Comparison With Other Studiesmentioning

confidence: 91%

“…The study concluded, that inclusion of additional risk factors into the S-IBIS is needed to reliably stratify women into the BC risk groups. 32 As shown above, the advantage of BC risk assessment is the use of S-IBIS, a BC risk calculator in the Slovenian breast centres, which could reduce the number of unnecessary preventive mammographies for the majority of women assessed with the population risk, giving room for symptomatic women and women at moderately increased and high risk. This was proved reasonable in all aforementioned Slovenian risk studies.…”

Section: Risk Stratification and Comparison With Other Studiesmentioning

confidence: 99%

“…This was proved reasonable in all aforementioned Slovenian risk studies. 25,31,32 Furthermore, risk-based screening is already ongoing in several countries across the world, but at the moment only in study settings. The English cohort study PROCAS conducted in the UK in the period from 2009 to 2020 and recruiting 63,000 women in two large studies (aged 50−70), concluded that the Tyrer-Cuzick risk prediction model (version 6) accurately predicts BC risk.…”

Section: Risk Stratification and Comparison With Other Studiesmentioning

confidence: 99%

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Breast cancer risk assessment and risk distribution in 3,491 Slovenian women invited for screening at the age of 50; a population-based cross-sectional study

Jarm,

Zadnik,

Birk

et al. 2023

Radiology and Oncology

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Background The evidence shows that risk-based strategy could be implemented to avoid unnecessary harm in mammography screening for breast cancer (BC) using age-only criterium. Our study aimed at identifying the uptake of Slovenian women to the BC risk assessment invitation and assessing the number of screening mammographies in case of risk-based screening. Patients and methods A cross-sectional population-based study enrolled 11,898 women at the age of 50, invited to BC screening. The data on BC risk factors, including breast density from the first 3,491 study responders was collected and BC risk was assessed using the Tyrer-Cuzick algorithm (version 8) to classify women into risk groups (low, population, moderately increased, and high risk group). The number of screening mammographies according to risk stratification was simulated. Results 57% (6,785) of women returned BC risk questionnaires. When stratifying 3,491 women into risk groups, 34.0% were assessed with low, 62.2% with population, 3.4% with moderately increased, and 0.4% with high 10-year BC risk. In the case of potential personalised screening, the number of screening mammographies would drop by 38.6% compared to the current screening policy. Conclusions The study uptake showed the feasibility of risk assessment when inviting women to regular BC screening. 3.8% of Slovenian women were recognised with higher than population 10-year BC risk. According to Slovenian BC guidelines they may be screened more often. Overall, personalised screening would decrease the number of screening mammographies in Slovenia. This information is to be considered when planning the pilot and assessing the feasibility of implementing population risk-based screening.

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Breast cancer risk prediction using Tyrer-Cuzick algorithm with an 18-SNPs polygenic risk score in a European population with below-average breast cancer incidence

Oblak,

Škerl,

Narang

et al. 2023

The Breast

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Breast cancer risk based on adapted IBIS prediction model in Slovenian women aged 40–49 years - could it be better?

Cited by 3 publications

References 24 publications

Association of Interleukin-10 Polymorphism (rs1800896, rs1800871, and rs1800872) With Breast Cancer Risk: An Updated Meta-Analysis Based on Different Ethnic Groups

Association of Interleukin-10 Polymorphism (rs1800896, rs1800871, and rs1800872) With Breast Cancer Risk: An Updated Meta-Analysis Based on Different Ethnic Groups

Breast cancer risk assessment and risk distribution in 3,491 Slovenian women invited for screening at the age of 50; a population-based cross-sectional study

Breast cancer risk prediction using Tyrer-Cuzick algorithm with an 18-SNPs polygenic risk score in a European population with below-average breast cancer incidence

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