Association of Interleukin-10 Polymorphism (rs1800896, rs1800871, and rs1800872) With Breast Cancer Risk: An Updated Meta-Analysis Based on Different Ethnic Groups

Li, Lijun; Xiong, Wei; Li, Donghua; Cao, Jiangang

doi:10.3389/fgene.2022.829283

Cited by 4 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with our MR analysis findings, multiple meta-analyses and observational studies have demonstrated a robust association between the inflammatory cytokines IL-5 and IL-16, and the susceptibility to breast cancer [ 12 – 14 ]. Previous experimental studies have suggested that IL-5 and IL-16 exhibit significant pro-inflammatory activity.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Inflammatory cytokines and two subtypes of breast cancer: A two-sample mendelian randomization study

Zhou,

Cai,

Yang

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Background Breast cancer is a common cancer type that leads to cancer-related deaths among women. HER2-positive breast cancer, in particular, is associated with poor prognosis due to its high aggressiveness, increased risk of recurrence, and metastasis potential. Previous observational studies have explored potential associations between inflammatory cytokines and the risk of two breast cancer subtypes (HER2-positive and HER2-negative), but the results have been inconsistent. To further elucidate the causal relationship between inflammatory cytokines and the two breast cancer subtypes, we conducted a two-sample Mendelian randomization (MR) study. Methods We employed a two-sample bidirectional MR analysis using publicly available genome-wide association study (GWAS) statistics. After obtaining instrumental variables, we conducted MR analyses using five different methods to ensure the reliability of our results. Additionally, we performed tests for heterogeneity and horizontal pleiotropy. Subsequently, we conducted a reverse MR study by reversing exposure and outcome variables. Results Evidence from our IVW analysis revealed that genetically predicted levels of IL-5 [odds ratio (OR): 1.18, 95% confidence interval (CI): 1.04–1.35, P = 0.012], IL-7 (OR: 1.11, 95% CI: 1.01–1.22, P = 0.037), and IL-16 (OR: 1.13, 95% CI: 1.02–1.25, P = 0.025) were associated with an increased risk of HER2-positive breast cancer. Conversely, IL-10 (OR: 1.14, 95% CI: 1.03–1.26, P = 0.012) was associated with an increased risk of HER2-negative breast cancer. These results showed no evidence of heterogeneity or horizontal pleiotropy (P > 0.05). Results from the reverse MR analysis indicated no potential causal association between breast cancer and inflammatory cytokines (P > 0.05). Conclusion Our findings demonstrate that IL-5, IL-7, and IL-16 are risk factors for HER2-positive breast cancer, with varying degrees of increased probability of HER2-positive breast cancer associated with elevated levels of these inflammatory cytokines. Conversely, IL-10 is a risk factor for HER2-negative breast cancer. Reverse studies have confirmed that breast cancer is not a risk factor for elevated levels of inflammatory cytokines. This series of results clarifies the causal relationship between different types of inflammatory cytokines and different subtypes of breast cancer. Based on this research, potential directions for the mechanism research of different inflammatory cytokines and different subtypes of breast cancer have been provided, and potential genetic basis for identifying and treating different subtypes of breast cancer have been suggested.

show abstract

Section: Discussionsupporting

confidence: 89%

“…and the susceptibility to breast cancer [12][13][14]. Previous experimental studies have suggested that IL-5 and IL-16 exhibit significant pro-inflammatory activity.…”

Section: Plos Onementioning

confidence: 99%

Inflammatory cytokines and two subtypes of breast cancer: A two-sample mendelian randomization study

Zhou,

Cai,

Yang

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…A meta-analysis published in 2021 confirmed the association between the rs1800872 variant and the risk of cervical cancer [ 18 ]. Several other meta-analyses have shown the association between this variant and the risk of breast cancer [ 19 , 20 ]. Our study found a trend toward a lower occurrence in NET patients compared to that in the control group.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Selected Single-Nucleotide Variants in Patients with Neuroendocrine Tumors—Potential Clinical Relevance

Kurzyńska

Pach

Skalniak

et al. 2022

JCM

View full text Add to dashboard Cite

Introduction: The genetic basis of neuroendocrine tumors (NETs), whose incidence is continuously increasing, is still not fully defined. The majority of NETs are sporadic, and only a small percentage occur as part of hereditary genetic syndromes. However, the associations of multiple genetic variants have been found as clinically relevant in several neoplasms. The aim of this study was to evaluate whether selected, literature-based genetic variants may have a potential role in NET susceptibility and clinical outcome in Polish patients. Materials/methods: A total of 185 patients recruited from one clinical center were enrolled. In the first part of the study, the molecular analysis including four single-nucleotide variants (rs8005354 (DAD1, NM_001344 intronic T/C substitution), rs2069762 (T/G substitution in the promoter region of the IL2 NM_000586), rs3731198 (CDKN2A, NM_000077 intronic A/G substitution), and rs1800872 (C/A substitution in the promoter region of the IL10 NM_000572)) was performed in 107 participants (49 patients with NETs with different primary site NETs and a control group of 58 healthy adult volunteers). In the second stage, the same single-nucleotide polymorphisms (SNPs) were assessed in 127 patients with NET and analyzed in terms of clinical data (primary site, serum CgA concentration, and metastatic disease). Results: The analysis of homozygotes revealed a statistically significant higher prevalence of TT homozygotes of variant rs3731198 in the control group (p = 0.0209). In NET patients, there was a statistically significant higher prevalence of GG homozygotes of variant rs1800872 (p = 0.003). There was a statistically significant correlation between the rs3731198 variant and lymph node metastases (p = 0.0038 with Bonferroni correction). Conclusions: Our study indicates that GG homozygotes of variant rs1800872 are more often observed in NET patients, while TT homozygotes of variant rs3731198 are less frequent in this group. The rs3731198 variant may be related to an increased risk of lymph node metastasis. Further, larger multicenter studies are warranted to evaluate the potential genetic factors of sporadic NETs.

show abstract

“…IL-8 is an important inflammatory factor, and many studies show that inflammation in the tumor microenvironment plays an important role in the progression of breast cancer [ 14 ]. IL-10 plays an important role in the pathogenesis of cancer: the excessive production of IL-10 increases the likelihood of tumors due to immunosuppression [ 6 , 15 , 16 , 17 ]. Elevated levels of IL-18 in the serum of patients with various forms of cancer correlate with the progression of the disease and the development of metastasis.…”

Section: Introductionmentioning

confidence: 99%

Pro-Inflammatory and Anti-Inflammatory Salivary Cytokines in Breast Cancer: Relationship with Clinicopathological Characteristics of the Tumor

Bel’skaya

Loginova

Sarf

2022

CIMB

View full text Add to dashboard Cite

The aim of the work was to compare the salivary cytokine profile of breast cancer patients with the clinicopathological characteristics of the tumor. The study included 113 patients with breast cancer (main group, mean age 54.1 years) and 111 patients with breast fibroadenomas (control group, mean age 56.7 years). Before treatment, saliva samples were collected from all patients and the content of cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-18, MCP-1, and TNF-α) was determined. The content of cytokines in saliva correlates well with the clinicopathological characteristics of breast cancer. The level of all salivary cytokines increases at advanced stages of breast cancer and at a low degree of tumor differentiation. The exception is MCP-1, for which there is an extremely high content for well-differentiated breast cancer. A statistically significant increase in the content of MCP-1, IL-1β, IL-2, IL-4, and IL-10 was found in triple-negative breast cancer. For the first time, the correlation of salivary levels of TNF-α, IL-1β, and IL-6 with HER2 status, MCP-1, IL-1β, IL-2, and IL-4 with the hormonal status of the tumor was shown. The relationship between the level of IL-2, IL-10, and IL-18 in saliva with the level of Ki-67 expression has been established.

show abstract

Association of Interleukin-10 Polymorphism (rs1800896, rs1800871, and rs1800872) With Breast Cancer Risk: An Updated Meta-Analysis Based on Different Ethnic Groups

Cited by 4 publications

References 45 publications

Inflammatory cytokines and two subtypes of breast cancer: A two-sample mendelian randomization study

Inflammatory cytokines and two subtypes of breast cancer: A two-sample mendelian randomization study

Prevalence of Selected Single-Nucleotide Variants in Patients with Neuroendocrine Tumors—Potential Clinical Relevance

Pro-Inflammatory and Anti-Inflammatory Salivary Cytokines in Breast Cancer: Relationship with Clinicopathological Characteristics of the Tumor

Contact Info

Product

Resources

About