Breast Cancer Mortality Among PVC Fabricators

Chiazze, Leonard; Wong, Otto; Nichols, William; Ference, Lorraine D.

doi:10.1097/00043764-198010000-00015

Cited by 9 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are of interest especially because vinyl chloride, a mammary carcinogen in animals, was used in hairsprays until the early 1970s. A nonsignificant increase in the risk of breast cancer was seen for workers exposed to polyvinyl chloride [Chiazze et al, 1977[Chiazze et al, , 1980.…”

Section: Discussionmentioning

confidence: 99%

The risk of breast cancer in relation to health habits and occupational exposures

Shaham

Gurvich²,

Goral³

et al. 2006

American J Industrial Med

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The risk of breast cancer in relation to health habits and occupational exposures

Shaham

Gurvich²,

Goral³

et al. 2006

American J Industrial Med

View full text Add to dashboard Cite

show abstract

“…Mikoczy and coworkers [1994] conducted a cohort study of leather tannery workers exposed to a number of compounds, including benzene and other chlorinated solvents, and found incidence rates to be between 30% and 50% above expected. A case-control analysis of a small cohort of polyvinylchloride workers showed a nonsignificantly elevated risk of death from breast cancer [Chiazze et al, 1977[Chiazze et al, , 1980. No associations were observed for mortality among styrene-exposed workers [Kogevinas et al, 1994;Wong, 1990;Wong et al, 1994], or for incidence among workers exposed to halogenated solvents [Anttila et al, 1995]; the latter study constituted its cohort from a database of workers monitored for halogenated solvent exposure between 1965 and 1982, and followed-up for cancer incidence between 1967 and 1992.…”

Section: Epidemiologymentioning

confidence: 99%

Exposure to organic solvents and breast cancer in women: A hypothesis

Labrèche

Goldberg

1997

Am. J. Ind. Med.

View full text Add to dashboard Cite

Incidence rates for breast cancer have increased steadily over the last 25 years, particularly among postmenopausal women. Secular changes in accepted and suspected risk factors can explain only a part of this increase. Given the increasing number of women in the workforce, it is possible that increases in breast cancer incidence may be caused by occupational exposure to hazardous agents. In particular, we hypothesize that organic solvents act directly as genotoxic agents or indirectly through their metabolites. Most organic solvents are highly lipophilic and are readily absorbed and distributed throughout the body via the bloodstream. Organic solvents are biotransformed mostly in the liver and the kidneys through a series of oxidative and reductive reactions, some of them resulting in bioactivation. There are indications of P‐450 enzymatic oxidative activity in the breast parenchyma, but there appears to be limited detoxification of highly reactive metabolites. The physiology of the breast may also accentuate the accumulation of chemicals: breast parenchyma is embedded in a fat depot capable of storing lipophilic xenobiotics; it is conceivable that organic solvents and their metabolites, once stored in fat tissues, migrate to the breast parenchyma and are then transferred to the mammary lobules through continuous apocrine secretions. These secretions may reside in the ductular system long enough for the solvents and their bioactivated metabolites to locally exert detrimental effects. The evidence supporting this hypothesis is that many organic solvents have been detected in breast milk, the majority of carcinomas occur in the ductular system, and some organic solvents have been shown to produce mammary gland cancer in experiments on rodents. Further toxicological and epidemiologic studies are required to test this hypothesis, to elucidate the mechanisms, and to identify specific carcinogenic organic solvents. Am. J. Ind. Med. 32:1114, 1997. © 1997 Wiley‐Liss, Inc.

show abstract

“…A case-control study in a small cohort of polyvinyl chloride workers showed a non-significantly increased risk of death from breast cancer (OR 1.8).61 162 No associations were found among workers exposed to styrene. [166][167][168] Lastly, among the studies based on administrative records, there have been suggestions of increased risks for certain occupations that may involve exposures to solvents (printing, publishing, mechanics).24 45 46 50 53 Discussion and conclusions This review has summarised results from occupational investigations of female breast cancer carried out within the past 25 years.…”

Section: Pharmaceutical Industrymentioning

confidence: 99%