Occupational risk factors for female breast cancer: a review.

Goldberg, Mark S.; Labrèche, France

doi:10.1136/oem.53.3.145

Cited by 83 publications

(99 citation statements)

References 149 publications

(30 reference statements)

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“…A comprehensive review of occupational risk factors for breast cancer among women revealed that few high-quality studies have been conducted that allow unambiguous conclusions (124). Notable exceptions are the longitudinal studies from Finland (125,126), in which occupations from censuses were linked with subsequent cancer incidence.…”

Section: Criteria Used For Selecting the Studiesmentioning

confidence: 99%

Epidemiologic estimate of the proportion of fatalities related to occupational factors in Finland

Nurminen¹,

Karjalainen²

2001

Scand J Work Environ Health

260

202

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Objectives This study attempts to estimate the proportion of annual deaths related to occupational factors in Finland and considers related methodological issues and associated uncertainties.Methods Statistics on causes of death, numbers of subjects exposed, and risk ratios obtained from the epidemiologic literature were used to estimate the population attributable fraction and disease burden for causes of death from work-related diseases. Gender-, age-and disease-specific numbers of deaths were provided by Statistics Finland for 1996. Information on the size of the population, broken down by gender, age, occupation, and industry, was acquired from population censuses. A Finnish job-exposure matrix supplied data on the prevalence of exposure for specific agents and the level of exposure among exposed workers. ResultsThe attributable fraction of work-related mortality in the relevant disease and age categories was estimated to be 7% (10% for men and 2% for women), and for all diseases and ages the fraction was 4%. For the main cause-of-death categories, the attributable fraction became 12% for circulatory system diseases, 8% for malignant neoplasms, 4% for respiratory system diseases, 4% for mental disorders, 3% for nervous system diseases, and 3% for accidents and violence. The following estimates were obtained for specific important diseases: 24% for lung cancer, 17% for ischemic heart disease, 12% for chronic obstructive pulmonary disease, and 11% for stroke. Based on these fractions, the total number of work-related deaths that occurred in Finland in 1996 was calculated to be on the order of 1800 (employed work force of 2.1 million); 86% involved men.Conclusions High-quality epidemiologic studies and national survey data are essential for obtaining reliable estimates of the proportion of deaths attributable to occupational factors. The magnitude of work-related mortality is an insufficiently recognized contributor to total mortality in Finland, especially from circulatory diseases and other diseases caused by exposure to agents other than asbestos.Key terms attributable fraction, burden of disease, epidemiologic methods, health statistics, occupational exposure. Global estimates of the burden of disease due to occupational factors have been calculated through the application of Finnish rates of registered work-related diseases (1). The approach is subject to the following two fundamental uncertainties: (i) the validity of the data on disease incidence from the national reporting scheme and (ii) the validity of worldwide extrapolations to different regions with different exposure circumstances. With the exception of studies using workers' compensation records, only a few research projects have estimated the magnitude of morbidity or mortality induced by exposure to hazardous agents or stress factors in the work environment at a state or national level. The investigations conducted in this area have covered New York State (2), the whole of the United States (3), Canada (4), and Australia (5). Given the lack of ...

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Section: Criteria Used For Selecting the Studiesmentioning

confidence: 99%

Epidemiologic estimate of the proportion of fatalities related to occupational factors in Finland

Nurminen¹,

Karjalainen²

2001

Scand J Work Environ Health

260

202

View full text Add to dashboard Cite

show abstract

“…As such jobs have been associated with a higher risks for breast cancer 31,32) , probably due to confounding from social and reproductive factors 32) , some underestimation of the ORs associated with blue collar workers' job titles may have ensued. We had, however, no other reasonable choice, as there were just a few warehouse operators, a potentially preferable reference group.…”

Section: Discussionmentioning

confidence: 99%

Female Breast Cancer and Electrical Manufacturing: Results of a Nested Case‐control Study

Oddone

Edefonti²,

Scaburri

et al. 2014

Journal of Occupational Health

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“…Women's traditional work histories and the tendency to focus occupational studies on men means that these studies have not been a resource for identifying chemical risk factors for breast cancer. 22 While there is a pressing need for studies of occupationally exposed women, the study of chemical factors in breast cancer also requires efforts to develop new measures to piece together exposures that may be lower and more diverse than in occupational settings. For example, it would be useful to characterize patterns of exposure to HAAs and MCs in consumer products.…”

Section: Introductionmentioning

confidence: 99%

Identification of Selected Hormonally Active Agents and Animal Mammary Carcinogens in Commercial and Residential Air and Dust Samples

Rudel

Brody

Spengler

et al. 2001

Journal of the Air & Waste Management Association

126

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In order to characterize typical indoor exposures to chemicals of interest for research on breast cancer and other hormonally mediated health outcomes, methods were developed to analyze air and dust for target compounds that have been identified as animal mammary carcinogens or hormonally active agents and that are used in commercial or consumer products or building materials. These methods were applied to a small number of residential and commercial environments to begin to characterize the extent of exposure to these classes of compounds. Phenolic compounds, including nonylphenol, octylphenol, bisphenol A, and the methoxychlor metabolite 2,2-bis (p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), were extracted, derivatized, and analyzed by gas chromatography/mass spectrometry (GC/MS)-selective ion monitoring (SIM). Selected phthalates, pesticides, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) were extracted and IMPLICATIONS Methods pilot-tested in this study can contribute to assessment of exposures to complex mixtures of hormonally active agents in homes. The 33 compounds detected, including phthalates, alkylphenols, and pesticides, are toxicologically important chemicals that are widespread in indoor environments, making them priorities for future research and regulatory evaluation. They also provide tools for the study of hormonally mediated health outcomes, including breast cancer. Application of these methods to a larger number of homes, with analysis of the relationship between indoor air and dust measures and urine measurements for selected analytes, is underway.analyzed by GC/MS-SIM. Residential and workplace samples showed detectable levels of twelve pesticides in dust and seven in air samples. Phthalates were abundant in dust (0.3-524 µg/g) and air (0.005-2.8 µg/m 3 ). Nonylphenol and its mono-and di-ethoxylates were prevalent in dust (0.82-14 µg/g) along with estrogenic phenols such as bisphenol A and o-phenyl phenol. In this 7-sample pilot study, 33 of 86 target compounds were detected in dust, and 24 of 57 target compounds were detected in air. In a single sample from one home, 27 of the target compounds were detected in dust and 15 in air, providing an indication of chemical mixtures to which humans are typically exposed. INTRODUCTIONBreast cancer is the most common malignancy among women in the United States and western Europe 1 and the leading cause of cancer death in women aged 35-54.2 Wide variations in breast cancer incidence around the world

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Occupational risk factors for female breast cancer: a review.

Cited by 83 publications

References 149 publications

Epidemiologic estimate of the proportion of fatalities related to occupational factors in Finland

Epidemiologic estimate of the proportion of fatalities related to occupational factors in Finland

Female Breast Cancer and Electrical Manufacturing: Results of a Nested Case‐control Study

Identification of Selected Hormonally Active Agents and Animal Mammary Carcinogens in Commercial and Residential Air and Dust Samples

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