Breast cancer molecular subtypes in Omani patients: Correlation with age, histology, stage distribution, and outcome—An anaylsis of 542 cases.

Mehdi, Itrat; Abdulmasood, A. a.; Bahrani, Bassim Al

doi:10.1200/jco.2011.29.27_suppl.219

Cited by 13 publications

(16 citation statements)

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“…Our study found that the average age of the patients was 49 years, which was in accordance with national average as reported by the Saudi Arabian Cancer Incidence Report [4,19]. Most of our cases (54.3%) were detected in women who were younger than 50 years of age, which is again similar to a recently reported study from Oman [20]. These results were in contrast to the observations in US where 65.1% of the reported cases were found in women older than 55 years of age, as evident from the Surveillance, Epidemiology, and End Results (SEER) Cancer Statistics Review [5].…”

Section: Discussionsupporting

confidence: 92%

Molecular classification of breast cancer: A retrospective cohort study

Althoubaity

2020

Annals of Medicine and Surgery

104

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ObjectivesThe study was aimed to determine the distribution of various breast cancer molecular subtypes in Saudi Arabia. Further, association between these subtypes and different epidemiological features was assessed.MethodsA retrospective study was conducted between January 2012 and December 2018, at the King Abdul Aziz University Hospital. A total of 740 cases of breast cancer, using immunohistochemistry, were classified into 4 major molecular subtypes: luminal A, luminal B, HER2-positive, and triple negative. Chi-squared test was performed to evaluate the relationship between these subtypes and clinico-pathological features.ResultsLuminal A (58.5%) subtype was the most prevalent, followed by triple negative (16%), luminal B (14%), and HER2-positive (11.5%). The average age of the patient at the time of diagnosis was found to be 49 years with an average tumor size of 3.2 cm. Out of all cases, 85% of cases were ductal, while 11.4% were lobular. 66.6% showed axillary lymph node metastases. While, 77% of lobular carcinomas were found almost exclusively in the luminal A and triple negative tumor subtype, 69.5% had modified radical mastectomy.ConclusionsLuminal A tumor was the most prevalent subtype, while HER2-positive was the least prevalent. Luminal A tumors were mostly associated with lobular carcinomas. HER2-positive and triple negative tumors showed higher histological grade and larger tumor size at the time of diagnosis. These tumors were commonly found in women below the age of 50 years. Carcinoma-in-situ was less prevalent in HER2-positive tumors. Furthermore, a strong association was observed between axillary lymph node status and molecular subtypes.

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Section: Discussionsupporting

confidence: 92%

Molecular classification of breast cancer: A retrospective cohort study

Althoubaity

2020

Annals of Medicine and Surgery

104

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“…While the use of these biomarkers plays an important role in diagnostic and clinical practice and the guidance of endocrine therapy, very few studies have been reported in our study population. The tumour classifications identified in this study were comparable to studies performed in other countries [ 22 , 23 ]. However, our data show that the use of these biomarkers allows a definition of the type of breast cancer, which may be useful when selecting the best treatment or when establishing which patients have a higher risk of secondary effects from cytotoxic treatments.…”

Section: Discussionsupporting

confidence: 87%

The association of subtypes of breast cancer with tumour characteristics and reproductive factors in 1326 Mexican women

Pérez-Rodríguez¹,

Aranda-Moreno²,

Olivares-Corichi³

et al. 2015

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Aim of the studyIn breast cancer, oestrogen receptor (ER), progesterone receptor (PgR), and HER2 (HER2/Neu) expression status are used to classify neoplasms into subtypes: Luminal A, Luminal B, HER2/Neu type, and Basallike. The aim of the present study was to establish the molecular subtypes of breast cancers and their association with tumour characteristics and reproductive factors in Mexican women.Material and methodsA total of 1326 biopsies of breast tumour tissues were analysed for ER, PR, and HER2/Neu by immunohistochemistry (IHC). Information regarding age, tumour characteristics, and node involvement profiles were collected.ResultsIHC established that the most common subtype of breast cancer was Luminal A (64.93%), followed by Basal-Like (13.88%), Luminal B (12.52%), and HER2/Neu (8.67%). T2-size tumours (> 2 cm but < 5 cm) were present in 47.59% of all patients. Univariate analysis showed that lymph node positivity (p = 0.009), stage (p = 0.013), and placement of the tumour (p = 0.001) were factors associated with breast cancer subtype.ConclusionsOur data show that IHC is useful for distinguishing different subtypes of breast cancer and that Luminal A is the most common breast cancer subtype in the Mexican population. All subtypes were associated with unfavourable clinicopathological features, suggesting that late diagnosis is an important contributor to high mortality rates in the Mexican population.

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“… 4 Most of our cases (57.9%) occurred in women <50 years, which is similar to the Omani study. 16 In contrast, in the United States, 65.1% of cases occurred in women older than 55 years according to the Surveillance, Epidemiology, and End Results (SEER) Cancer Statistics Review in the period from 2001 to 2005. 2 Notably, while only 33.15% of our patients presented with a tumor size <2 cm, in countries like the United States and Poland, the percentage of patients presenting with a tumor size ≤2 cm is considerably higher, being 58.4% and 51.9%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“… 10 , 11 Racial differences in the distribution of breast cancer are well documented. 12 , 13 While luminal A is the most prevalent subtype in most regions, 12 it is worth noting that the frequency of triple negative tumors is high among certain communities, such as African American, 14 , 15 Omani, 16 and Tunisian. 17 In 2010, Tamimi et al 18 analyzed 5 immunohistochemistry markers (ER, PR, HER2, epidermal growth factor receptor [EGFR], and Chromosome [CK] 5/6) in 231 breast cancer cases located in the Eastern Province of Saudi Arabia.…”

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confidence: 99%

Molecular subtypes of breast carcinoma in Saudi Arabia

Alnegheimish

Alshatwi

Alhefdhi

et al. 2016

SMJ

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Objectives:To determine the distribution of various molecular subtypes of breast cancer in Saudi Arabia and to assess the association between these subtypes and age at diagnosis, tumor size, histopathological type, grade, presence of carcinoma in-situ, and lymph node status.Methods:This observational retrospective study, between January 2010 and December 2014, was conducted at King Khalid University Hospital, Riyadh, Saudi Arabia. We classified 359 breast cancers into 4 molecular subtypes, using immunohistochemistry: luminal A (estrogen receptor [ER], or progesterone receptor [PR] positive and human epidermal growth factor receptor 2 [HER2] negative), luminal B (ER and/or PR positive and HER2 positive), HER2-positive (ER and PR negative and HER2 positive), and triple negative (ER, PR, and HER2 negative). We evaluated the relationship between these subtypes and clinicopathological features using Chi square test.Results:The most prevalent subtype was luminal A (58.5%), followed in descending order of frequency by triple negative (14.8%), luminal B (14.5%), and HER2-positive (12.3%). The average age at diagnosis was 49.8 years, and average tumor size at diagnosis was 3.19 cm.Conclusion:Luminal A tumor was the most common molecular subtype and HER2-positive was the least common. Most lobular carcinomas were luminal A tumors. Human epidermal growth factor receptor 2-positive and triple negative tumors had a higher histologic grade and a larger tumor size at diagnosis, and they were more common in women under 50 years. Carcinoma-in-situ was least common in triple negative tumors. We found no association between lymph node status and molecular subtypes.

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Breast cancer molecular subtypes in Omani patients: Correlation with age, histology, stage distribution, and outcome—An anaylsis of 542 cases.

Cited by 13 publications

References 0 publications

Molecular classification of breast cancer: A retrospective cohort study

Molecular classification of breast cancer: A retrospective cohort study

The association of subtypes of breast cancer with tumour characteristics and reproductive factors in 1326 Mexican women

Molecular subtypes of breast carcinoma in Saudi Arabia

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