Breast cancer in very young women—a multicenter 10-year experience

Eiriz, Inês; Batista, Marta Vaz; Tomás, T.; Neves, Maria Teresa; Guerra-Pereira, N.

doi:10.1016/j.esmoop.2020.100029

Cited by 25 publications

(17 citation statements)

References 38 publications

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“…Over the past years, with an increasing prevalence of breast cancer worldwide ( 1 – 4 , 6 ), the comprehensive and individualized management for patients with this particular disease has gradually attracted much attention, especially in terms of young breast cancer ( 7 , 9 , 10 , 14 , 15 ). It was believed that age was an independent prognostic indicator among female breast cancer and younger age, especially under the age of 40 years, frequently presented a higher risk of locoregional metastasis, recurrence, and ultimately worse OS outcomes ( 7 , 10 , 12 ). Indeed, while surgery remained to be the first-line strategy in the management of breast cancer, great changes have taken place in terms of the surgical extension ( 8 , 16 ), especially with the wide application of neoadjuvant chemotherapy ( 17 , 18 ) and postoperative radiation therapy ( 19 ) for early-stage breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, only a small number of listed studies were focused on investigating the risk factors for predicting the clinical outcomes in young women with breast cancer ( 10 , 12 ). For instance, based on the clinicopathological features of the large-scale population, Billena et al ( 9 ) determined that tumor size, hormone receptor status, surgery, adjuvant therapies, lymph node status, and race were independent predictive factors for overall survival (OS) in young female breast cancer.…”

Section: Introductionmentioning

confidence: 99%

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Cancer-Specific Survival Outcome in Early-Stage Young Breast Cancer: Evidence From the SEER Database Analysis

Xiao

et al. 2022

Front. Endocrinol.

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BackgroundYoung women with breast cancer are determined to present poorer survival compare with elderly patients. Therefore, identifying the clinical prognostic factors in young women with early-stage (T1-2N0-1M0) breast cancer is pivotal for surgeons to make better postoperative management.MethodsThe clinicopathological characteristics of female patients with early-stage breast cancer from the Surveillance, Epidemiology, and End Results program between Jan 2010 and Dec 2015 were retrospectively reviewed and analyzed. Univariate and multivariate Cox regression analyses were used to determine the potential risk factors of cancer-specific survival in young women with early-stage breast cancer. The nomogram was constructed and further evaluated by an internal validation cohort. The Kaplan-Meier survival curves were used to estimate cancer-specific survival probability and the cumulative incidence.ResultsSix variables including race, tumor location, grade, regional lymph node status, tumor subtype, and size were identified to be significantly associated with the prognosis of young women with early-stage breast cancer during the postoperative follow-up. A nomogram for predicting the 3-, 5- year cancer-specific survival probability in this subpopulation group was established with a favorable concordance index of 0.783, supported by an internal validation cohort with the AUC of 0.722 and 0.696 in 3-, 5- year cancer-specific survival probability, respectively.ConclusionsThe first predictive nomogram containing favorable discrimination is successfully established and validated for predicting the 3-, 5- year cancer-specific survival probability in young women with early-stage breast cancer during the postoperative follow-up. This model would help clinicians to make accurate treatment decisions in different clinical risk population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cancer-Specific Survival Outcome in Early-Stage Young Breast Cancer: Evidence From the SEER Database Analysis

Xiao

et al. 2022

Front. Endocrinol.

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“…Although female breast cancer (BC) under the age of 40 accounts for about 7–10% of all BCs ( 1 ), it is the most common malignant tumor among young patients ( 2 ). Moreover, young BC is the leading cause of cancer death in this age group ( 3 ). Previous studies have shown that young BC patients present with more aggressive clinical characteristics and poor outcome compared with elderly ( 2 , 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Establishment and Verification of Prognostic Nomograms for Young Women With Breast Cancer Bone Metastasis

Wang

Shao

et al. 2022

Front. Med.

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PurposeThe prognosis of patients with metastatic breast cancer usually varies greatly among individuals. At present, the application of nomogram is very popular in metastatic tumors. The present study was conducted to identify independent survival predictors and construct nomograms among young women with breast cancer bone metastasis (BCBM).Patients and MethodsWe searched the Surveillance, Epidemiology, and End Results (SEER) database to identify young women diagnosed with BCBM between 2010 and 2016. We first analyzed the potential risk factors of overall survival (OS) and cancer-specific survival (CSS) by applying univariate Cox regression analysis. Then we conducted multivariate Cox analysis to identify independent survival predictors. Based on significant independent predictors, we developed and validated novel prognostic nomograms by using the R version 4.1.0 software.ResultsWe finally identified 715 eligible young women with BCBM for survival analysis, of which 358 patients were in the training set, and 357 patients in the validation set. Approximately four-fifths of patients are between 31 and 40 years old. The 5-year OS and CSS rates of this research population were 41.9 and 43.3%, respectively. Multivariate analysis revealed seven independent predictors of both OS and CSS, including race, tumor subtype, tumor size, surgical treatment, brain metastasis, liver metastasis, and lung metastasis. Based on these predictors, we developed and validated OS and CSS nomograms. The C-index of the OS nomogram reached 0.728 and 0.73 in the training and validation sets, respectively. The C-index of the CSS nomogram reached 0.743 and 0.695 in the training and validation sets, respectively. Meanwhile, high quality calibration plots were revealed in both OS and CSS nomograms.ConclusionThe current novel nomograms can provide an individualized survival evaluation of young women with BCBM and instruct clinicians to treat them appropriately.

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“…Furthermore, breast cancer presents differences in young pre-menopausal women and in older post-menopausal women [ 12 ], with ER negative cases being more frequently in the young.…”

Section: Introductionmentioning

confidence: 99%

Hormone Receptor Expression Variations in Normal Breast Tissue: Preliminary Results of a Prospective Observational Study

Santandrea

Bellarosa

Gibertoni

et al. 2021

JPM

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Normal breast tissue undergoes great variations during a woman’s life as a consequence of the different hormonal stimulation. The purpose of the present study was to examine the hormonal receptor expression variations according to age, menstrual cycle, menopausal state and body mass index. To this purpose, 49 tissue samples of normal breast tissue, obtained during surgery performed for benign and malignant conditions, were immunostained with Estrogen (ER), Progesterone (PR) and Androgen receptors (AR). In addition, Ki67 and Gross Cystic Disease Fluid Protein were studied. The data obtained revealed a great variability of hormone receptor expression. ER and AR generally increased in older and post-menopausal women, while young women presented a higher proliferative rate, evaluated with Ki67. PR increase was observed in women with BMI higher than 25. The different hormonal receptor expression could favor the development of breast cancer.

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Breast cancer in very young women—a multicenter 10-year experience

Cited by 25 publications

References 38 publications

Cancer-Specific Survival Outcome in Early-Stage Young Breast Cancer: Evidence From the SEER Database Analysis

Cancer-Specific Survival Outcome in Early-Stage Young Breast Cancer: Evidence From the SEER Database Analysis

Establishment and Verification of Prognostic Nomograms for Young Women With Breast Cancer Bone Metastasis

Hormone Receptor Expression Variations in Normal Breast Tissue: Preliminary Results of a Prospective Observational Study

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