Breast cancer and environmental contamination: A real connection?

Delgado‐López, Fernando; Zamora-León, Pilar

doi:10.1080/2331205x.2018.1520470

Cited by 3 publications

(3 citation statements)

References 89 publications

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“…Environmental exposure to chemical toxicants is a major concern because it might explain the currently increasing incidence of breast cancer worldwide. In particular, an accumulating body of evidence has led many scientists to believe that exposure to xenoestrogens during critical windows of mammary gland development is associated with an increased risk of breast cancer later in life [14,[35][36][37][38]. The following discussion will highlight the role of BPA in the development of chemoresistance in breast cancer as summarized in Fig.…”

Section: Bpa and Breast Cancermentioning

confidence: 99%

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy

Hafezi

Abdel‐Rahman

2019

CMP

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Background: Bisphenol A (BPA) is a synthetic plasticizer that is commonly used in the production of polycarbonate plastics and epoxy resins. Human exposure occurs when BPA migrates from food and beverage containers into the contents when heated or even under normal conditions of use. BPA exerts endocrine disruptor action due to its weak binding affinity for the estrogen receptors ERα and ERβ. BPA exerts other effects by activating the membrane receptor GPER (GPR30) and/or other receptors such as the estrogen-related receptors (ERRs). Objective: This review summarizes emerging data on BPA and cancer. These include data linking exposure to BPA with an increased risk of hormone-related cancers such as those of the ovary, breast, prostate, and even colon cancer. BPA can also induce resistance to various chemotherapeutics such as doxorubicin, cisplatin, and vinblastine in vitro. The development of chemoresistance to available therapeutics is an emerging significant aspect of BPA toxicity because it worsens the prognosis of many tumors. Conclusion: Recent findings support a causal role of BPA at low levels in the development of cancers and in dictating their response to cytotoxic therapy. Accurate knowledge and consideration of these issues would be highly beneficial to cancer prevention and management.

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Section: Bpa and Breast Cancermentioning

confidence: 99%

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy

Hafezi

Abdel‐Rahman

2019

CMP

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“…The effects induced by DES are important to understand because many xenoestrogens polluting the environment have similar effects. Common molecular pathways are altered, leading to breast and reproductive tract cancers and other health problems [91,92]. DES, like other EDCs, can enter our bodies not only as a drug but also as a toxic pollutant and through the food chain.…”

Section: Discussionmentioning

confidence: 99%

Are the Effects of DES Over? A Tragic Lesson from the Past

Zamora-León

2021

IJERPH

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Diethylstilbestrol (DES), a transplacental endocrine-disrupting chemical, was prescribed to pregnant women for several decades. The number of women who took DES is hard to know precisely, but it has been estimated that over 10 million people have been exposed around the world. DES was classified in the year 2000 as carcinogenic to humans. The deleterious effects induced by DES are very extensive, such as abnormalities or cancers of the genital tract and breast, neurodevelopmental alterations, problems associated with socio-sexual behavior, and immune, pancreatic and cardiovascular disorders. Not only pregnant women but also their children and grandchildren have been affected. Epigenetic alterations have been detected, and intergenerational effects have been observed. More cohort follow-up studies are needed to establish if DES effects are transgenerational. Even though DES is not currently in use, its effects are still present, and families previously exposed and their later generations deserve the continuity of the research studies.

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“…PAH biotransformation has been implicated in the development of different types of cancers, such as lung, skin and breast cancer 1,[8][9][10][11] . Considering that everybody is exposed to PAH, but since breast cancer is the most prevalent cancer among women and the second cause of cancer-related death in the world 12,13,14 , we will focus in the effects of PAHs and breast cancer. As a result of the metabolism of PAH, reactive diol epoxide enantiomers are generated, which can bind and alter DNA by forming DNA adducts.…”

Section: Introductionmentioning

confidence: 99%

Polycyclic Aromatic Hydrocarbons and their Association with Breast Cancer

Zamora-León¹,

Delgado‐López²

2020

Bangladesh J Med Sci

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Background and Rationale: Polycyclic aromatic hydrocarbons are a lipophilic group of pollutants that persist in the atmosphere for long periods, constituting a permanent source of exposure for humans. They have been associated, for a long time, with the risk in developing breast cancer, but there are still unresolved questions. Conclusion: Integrated strategies are required that should consider molecular and population-level studies, to understand and elaborate approaches to prevent the risks in developing breast cancer. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.194-199

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Breast cancer and environmental contamination: A real connection?

Cited by 3 publications

References 89 publications

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy

Are the Effects of DES Over? A Tragic Lesson from the Past

Polycyclic Aromatic Hydrocarbons and their Association with Breast Cancer

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