Breaking the ice to improve motor outcomes in patients with chronic stroke: a retrospective clinical study on neuromodulation plus robotics

Naro, Antonino; Billeri, Luana; Manuli, Alfredo; Balletta, Tina; Cannavó, Antonino; Portaro, Simona; Lauria, Paola; Ciappina, Fabrizio; Calabrò, Rocco Salvatore

doi:10.1007/s10072-020-04875-8

Cited by 13 publications

(49 citation statements)

References 66 publications

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“…Previous studies have shown that if an intensive and multidisciplinary rehabilitation program starts early, then the cognitive and motor recovery will be better. Therefore, it is possible to attribute part of the recovery occurring immediately after the CP to this surgical procedure, while the gradual improvement of cognitive and functional outcomes is probably due to a competitive effect between the surgical procedure and rehabilitation [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Can Cranioplasty Be Considered a Tool to Improve Cognitive Recovery Following Traumatic Brain Injury? A 5-Years Retrospective Study

Corallo

Buono

Calabrò

et al. 2021

JCM

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Cranioplasty (CP) is a neurosurgical intervention of skull repairing following a decompressive craniectomy. Unfortunately, the impact of cranioplasty on cognitive and motor function is still controversial. Fifteen TBI subjects aged 26–54 years with CP after decompressive craniectomy were selected in this observational retrospective study. As per routine clinical practice, a neuropsychological evaluation carried out immediately before the cranioplasty (Pre CP) and one month after the cranioplasty (T0) was used to measure changes due to CP surgery. This assessment was performed each year for 5 years after discharge in order to investigate long-term cognitive changes (T1-T5). Before cranioplasty, about 53.3% of subjects presented a mild to severe cognitive impairment and about 40.0% a normal cognition. After CP, we found a significant improvement in all neuropsychological test scores. The more significant differences in cognitive recovery were detected after four years from CP. Notably, we found significant differences between T4 and T0-T1, as well as between T5 and T0-T1-T2 in all battery tests. This retrospective study further suggests the importance of CP in the complex management of patients with TBI showing how these patients might improve their cognitive function over a long period after the surgical procedure.

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Section: Discussionmentioning

confidence: 99%

Can Cranioplasty Be Considered a Tool to Improve Cognitive Recovery Following Traumatic Brain Injury? A 5-Years Retrospective Study

Corallo

Buono

Calabrò

et al. 2021

JCM

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“…Twentyseven studies did not meet the inclusion criteria. Finally, nine studies fulfilled the inclusion criteria and were included in the systematic review (Geroin et al, 2011;Picelli et al, 2015Picelli et al, , 2018Leon et al, 2017;Seo et al, 2017;Manji et al, 2018;Madhavan et al, 2020;Mitsutake et al, 2021;Naro et al, 2021). Then, six of these studies were included in the meta-analysis (Geroin et al, 2011;Picelli et al, 2015;Seo et al, 2017;Manji et al, 2018;Madhavan et al, 2020;Mitsutake et al, 2021).…”

Section: Search Selectionmentioning

confidence: 99%

“…Six RCTs (Geroin et al, 2011;Picelli et al, 2015Picelli et al, , 2018Seo et al, 2017;Madhavan et al, 2020;Mitsutake et al, 2021), one crossover trial (Manji et al, 2018), one active-control article (Leon et al, 2017), and one retrospective clinical trial (Naro et al, 2021) were included in this study. The sample sizes ranged from 20 (Picelli et al, 2015(Picelli et al, , 2018 to 41 (Madhavan et al, 2020), and the participants were divided into the intervention and control groups.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…In addition, the stroke phase at baseline ranged from 37.1 days (Mitsutake et al, 2021) to 152.5 months (Seo et al, 2017) after onset. Seven studies that reported results from the 10 MWT (Geroin et al, 2011;Leon et al, 2017;Seo et al, 2017;Manji et al, 2018;Madhavan et al, 2020;Mitsutake et al, 2021;Naro et al, 2021), six studies reported results from the 6 MWT (Geroin et al, 2011;Picelli et al, 2015Picelli et al, , 2018Seo et al, 2017;Madhavan et al, 2020;Naro et al, 2021), six studies reported FAC (Geroin et al, 2011;Picelli et al, 2015Picelli et al, , 2018Leon et al, 2017;Seo et al, 2017;Naro et al, 2021), three studies reported walking cadence (Geroin et al, 2011;Picelli et al, 2015Picelli et al, , 2018, and two studies reported results from the TUGT (Manji et al, 2018;Madhavan et al, 2020).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Previous studies have demonstrated an increase in corticospinal tract excitability by adapting robotic training after tDCS (Giacobbe et al, 2013;Powell et al, 2016). In contrast, another study showed that tDCS to bilateral primary motor areas while performing RAGT was more effective for the recovery of lower limb function in patients with stroke (Naro et al, 2021). Thus, it remains unclear which application timing of tDCS is optimal.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Combining Online Anodal Transcranial Direct Current Stimulation and Gait Training in Stroke Patients: A Systematic Review and Meta-Analysis

Mitsutake

Imura

Hori

et al. 2021

Front. Hum. Neurosci.

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Objective: Combining transcranial direct current stimulation (tDCS) and repetitive gait training may be effective for gait performance recovery after stroke; however, the timing of stimulation to obtain the best outcomes remains unclear. We performed a systematic review and meta-analysis to establish evidence for changes in gait performance between online stimulation (tDCS and repetitive gait training simultaneously) and offline stimulation (gait training after tDCS).Methods: We comprehensively searched the electronic databases Medline, Cochrane Central Register of Controlled Trials, Physiotherapy Evidence Database, and Cumulative Index to Nursing and Allied Health Literature, and included studies that combined cases of anodal tDCS with motor-related areas of the lower limbs and gait training. Nine studies fulfilled the inclusion criteria and were included in the systematic review, of which six were included in the meta-analysis.Result: The pooled effect estimate showed that anodal tDCS significantly improved the 10-m walking test (p = 0.04; I2 = 0%) and 6-min walking test (p = 0.001; I2 = 0%) in online stimulation compared to sham tDCS.Conclusion: Our findings suggested that simultaneous interventions may effectively improve walking ability. However, we cannot draw definitive conclusions because of the small sample size. More high-quality studies are needed on the effects of online stimulation, including various stimulation parameters.

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Neuro-Gerontechnologies: Applications and Opportunities

Barresi

Zenzeri

Tessadori

et al. 2022

Studies in Computational Intelligence

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Breaking the ice to improve motor outcomes in patients with chronic stroke: a retrospective clinical study on neuromodulation plus robotics

Cited by 13 publications

References 66 publications

Can Cranioplasty Be Considered a Tool to Improve Cognitive Recovery Following Traumatic Brain Injury? A 5-Years Retrospective Study

Can Cranioplasty Be Considered a Tool to Improve Cognitive Recovery Following Traumatic Brain Injury? A 5-Years Retrospective Study

Effects of Combining Online Anodal Transcranial Direct Current Stimulation and Gait Training in Stroke Patients: A Systematic Review and Meta-Analysis

Neuro-Gerontechnologies: Applications and Opportunities

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