Breakdown of the Blood-aqueous Barrier after Argon Laser Panretinal Photocoagulation for Proliferative Diabetic Retinopathy

Moriarty, A P; Spalton, David J.; Shilling, J S; Ffytche, T. J.; Bulsara, Max

doi:10.1016/s0161-6420(96)30607-6

Cited by 40 publications

(29 citation statements)

References 21 publications

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“…This increase in the aqueous flare intensity confirms that breakdown of the blood-aqueous barrier can be induced by retinal laser photocoagulation. Moriarty et al 33 have used laser flare photometry to evaluate the breakdown of the blood-aqueous barrier after panretinal photocoagulation in patients with proliferative diabetic retinopathy. It has been suggested that panretinal photocoagulation can induce uveal effusion and anterior chamber shallowing, which may lead to increased ciliary body venous pressure.…”

Section: Discussionmentioning

confidence: 99%

“…The reduced ciliary body venous drainage can lead to subsequent leakage of protein into the aqueous. 12,15,33 However, Inoue et al 34 have evaluated the disruption of the blood-aqueous barrier after retinal laser photocoagulation in pigmented rabbits by laser flare photometry. Since anterior chamber changes were not observed in this study, it is postulated that breakdown of the blood-retinal barrier after retinal laser photocoagulation may allow for the release of protein and exogenous inflammatory substances, such as prostaglandins and cytokines, into the vitreous.…”

Section: Discussionmentioning

confidence: 99%

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Role of Vascular Endothelial Growth Factor in the Breakdown of the Blood-Aqueous Barrier After Retinal Laser Photocoagulation in Pigmented Rabbits

Chen

Chang²,

Lin³

et al. 2012

Journal of Ocular Pharmacology and Therapeutics

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Purpose: Retinal laser photocoagulation is used to treat a variety of retinal diseases. Breakdown of the bloodaqueous barrier has been noted after retinal laser photocoagulation. The effect of vascular endothelial growth factor (VEGF) on the function of the blood-aqueous barrier after retinal laser photocoagulation remains undetermined. The current study was designed to evaluate the relationship between intraocular levels of VEGF and breakdown of the blood-aqueous barrier after retinal laser photocoagulation in rabbits. Methods: Pigmented rabbits were treated with retinal laser photocoagulation in one eye; the other served as control. Laser flare photometry was carried out on post-treatment days 1, 3, 7, and 14. Animals were sacrificed at the time period just mentioned postlaser, the eyes were removed, and samples of vitreous and aqueous humor were collected. Intraocular VEGF levels were measured by using an immunoassay. An intravitreal injection of VEGF was administered, and the aqueous flare intensity and VEGF levels in the aqueous and vitreous humor were measured at the time periods just mentioned.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Role of Vascular Endothelial Growth Factor in the Breakdown of the Blood-Aqueous Barrier After Retinal Laser Photocoagulation in Pigmented Rabbits

Chen

Chang²,

Lin³

et al. 2012

Journal of Ocular Pharmacology and Therapeutics

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“…The increase in flare values demonstrates a concomitant disruption of the BAB after retinal photocoagulation. Recently, laser flare photometry has been used to assess BAB breakdown after panretinal photocoagulation in prolifera- tive diabetic retinopathy [18]. It has been suggested that the increase in venous pressure of the ciliary body after laser photocoagulation causes shallowing of the anterior chamber, contributing to an increase in flare values [12,15,18].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, laser flare photometry has been used to assess BAB breakdown after panretinal photocoagulation in prolifera- tive diabetic retinopathy [18]. It has been suggested that the increase in venous pressure of the ciliary body after laser photocoagulation causes shallowing of the anterior chamber, contributing to an increase in flare values [12,15,18]. However, since anterior segment changes were not observed in this study, it is postulated that BRB disruption may allow for the release of protein and exogenous inflammatory products, such as PGs and cytokines, into the vitreous.…”

Section: Discussionmentioning

confidence: 99%

Disruption of the Blood-Aqueous Barrier following Retinal Laser Photocoagulation and Cryopexy in Pigmented Rabbits

et al. 2000

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Disruption of the blood-aqueous barrier (BAB) induced by retinal photocoagulation and cryopexy in pigmented rabbits was evaluated by laser flare photometry. A significant increase in flare values after retinal photocoagulation was measured from the 1st postoperative day, with values returning to baseline levels by day 7. Cryopexy induced consistently high flare values for 14 days. Intravitreal injection of interleukin (IL) 1, IL-6 and prostaglandin (PG) E₂ induced a significant increase in flare values. Following these treatments, introduction of a PG synthetase inhibitor can partially ameliorate BAB disruption. IL-1, IL-6 and PGE₂ may be involved in BAB disruption following retinal photocoagulation and cryopexy.

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“…Kato et al [16] and Nguyen et al [20] observed that the laser flare intensity in diabetics correlated with the extent of avascular areas and vascular changes in the retina. Diabetic retina may induce the release of growth factors that lead to neovascularization of the retina and the iris.…”

Section: Discussionmentioning

confidence: 99%

Iridopathy in Eyes with Proliferative Diabetic Retinopathy: Detection of Early Stage of Rubeosis Iridis

Inoue¹,

Azumi²,

Shirabe³

et al. 1997

Ophthalmologica

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Forty-two eyes of 31 proliferative diabetic retinopathy patients with laser flare intensity ≥ 20 photon counts/ms underwent fluorescein iris angiography to evaluate any changes in the blood-iris barrier and iris biomicroscopy to detect rubeosis iridis. Fluorescein iris angiography revealed abnormal dye leakage in all eyes. Laser flare intensity significantly correlated with the degree of dye leakage. Eyes with dye leakage from only the pupillary border had no rubeosis. In 11 out of 18 (61%) eyes with moderate dye leakage, proliferative diabetic iridopathy with early rubeosis was present in 8 and advanced iridopathy in 3 eyes. In all eyes with excessive leakage, rubeosis iridis was detected under slitlamp examination. High laser flare intensity has a close relationship with advanced blood-ocular barrier disruption. High flare intensity may be a helpful indicator in detecting incipient rubeosis or advanced diabetic iridopathy.

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Breakdown of the Blood-aqueous Barrier after Argon Laser Panretinal Photocoagulation for Proliferative Diabetic Retinopathy

Cited by 40 publications

References 21 publications

Role of Vascular Endothelial Growth Factor in the Breakdown of the Blood-Aqueous Barrier After Retinal Laser Photocoagulation in Pigmented Rabbits

Role of Vascular Endothelial Growth Factor in the Breakdown of the Blood-Aqueous Barrier After Retinal Laser Photocoagulation in Pigmented Rabbits

Disruption of the Blood-Aqueous Barrier following Retinal Laser Photocoagulation and Cryopexy in Pigmented Rabbits

Iridopathy in Eyes with Proliferative Diabetic Retinopathy: Detection of Early Stage of Rubeosis Iridis

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