Role of Vascular Endothelial Growth Factor in the Breakdown of the Blood-Aqueous Barrier After Retinal Laser Photocoagulation in Pigmented Rabbits

Abstract

Purpose: Retinal laser photocoagulation is used to treat a variety of retinal diseases. Breakdown of the bloodaqueous barrier has been noted after retinal laser photocoagulation. The effect of vascular endothelial growth factor (VEGF) on the function of the blood-aqueous barrier after retinal laser photocoagulation remains undetermined. The current study was designed to evaluate the relationship between intraocular levels of VEGF and breakdown of the blood-aqueous barrier after retinal laser photocoagulation in rabbits. Methods: Pigmented rabbits were treated with retinal laser photocoagulation in one eye; the other served as control. Laser flare photometry was carried out on post-treatment days 1, 3, 7, and 14. Animals were sacrificed at the time period just mentioned postlaser, the eyes were removed, and samples of vitreous and aqueous humor were collected. Intraocular VEGF levels were measured by using an immunoassay. An intravitreal injection of VEGF was administered, and the aqueous flare intensity and VEGF levels in the aqueous and vitreous humor were measured at the time periods just mentioned.

Transvitreal Fibrinoid Pseudoendophthalmitis After Diabetic Vitrectomy

“…Laser photocoagulation has been shown in previous studies to result in a breakdown of the blood aqueous barrier possibly leading to exudation of inflammatory material. 21,22 However, it is unusual that we have not seen this reaction more frequently if it is related to laser photocoagulation.…”

The Postvitrectomy Fibrin Response

“…34 Cryotherapy and laser photocoagulation have been shown to result in a breakdown of the blood-aqueous barrier, possibly leading to release of inflammatory mediators. 35,36 However, intraocular fibrin syndrome has not been reported to occur after cryotherapy or laser photocoagulation procedures alone in the absence of vitrectomy.…”

“…The increased occurrence of intraocular fibrin syndrome in diabetic patients is believed to occur from a deranged blood-ocular barrier, which may be a result of treatment, cryotherapy, a more common modality of treatment in the 1980s, exuberant endolaser,3 or severe diabetic retinopathy itself 34. Cryotherapy and laser photocoagulation have been shown to result in a breakdown of the blood-aqueous barrier, possibly leading to release of inflammatory mediators 35,36. However, intraocular fibrin syndrome has not been reported to occur after cryotherapy or laser photocoagulation procedures alone in the absence of vitrectomy.…”

Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran

“…[2][3][4] The visual function in PACG could be saved if early and proper treatments are adopted. [5] PACG is characterized by apposition between the peripheral iris and trabecular meshwork, which can ultimately lead to compromised outflow and high intraocular pressure (IOP). [6] Stress induced by IOP on optic disc results in compression, deformation, and remodeling of the lamina cribrosa with subsequent mechanical axonal damage and disruption of axonal transport or ischemic damage to the neural tissue.…”