Brazilian red propolis improves cutaneous wound healing suppressing inflammation-associated transcription factor NFκB

Corrêa, Flavia Regina Sobreira; Schanuel, Fernanda Seabra; Moura‐Nunes, Nathália; Monte‐Alto‐Costa, Andréa; Daleprane, Julio Beltrame

doi:10.1016/j.biopha.2016.12.018

Cited by 65 publications

(52 citation statements)

References 46 publications

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“…4 Recently, natural products have been investigated as alternative sources of drugs, and interest in the area of complementary and alternative medicine has increased, resulting in many studies on the use of natural products for tissue repair. 5 Propolis, a natural product produced by honeybees, has been used successfully in medicine as an anti-inflammatory and antimicrobial agent.…”

Section: Introductionmentioning

confidence: 99%

Effect of propolis on preserving human periodontal ligament cells and regulating pro‐inflammatory cytokines

Yuan

Wang

Shi

et al. 2018

Dental Traumatology

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Section: Introductionmentioning

confidence: 99%

Effect of propolis on preserving human periodontal ligament cells and regulating pro‐inflammatory cytokines

Yuan

Wang

Shi

et al. 2018

Dental Traumatology

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“…10,14,15 However, studies about the synthesis of metallic nanoparticles using Brazilian propolis are not available yet. The red propolis is classified as the 13th Brazilian propolis group based on its physicochemical characteristics, 16,17 in special the higher content of phenolic compounds, which gives a series of biological properties already reported in literature scaring properties, [18][19][20] a stabilizer, 14 antibacterial, [21][22][23][24] anti-inflammatory. 20,25,26 Given this information, the present study aimed to evaluate the biogenic synthesis of silver nanoparticles utilizing this Brazilian propolis.…”

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confidence: 99%

Biogenic synthesis of silver nanoparticles using Brazilian propolis

Barbosa

Souza

Alvino

et al. 2019

Biotechnology Progress

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Biological methods have been used to synthesize silver nanoparticles through materials such as bacteria, fungi, plants, and propolis due to their reducing properties, stabilizer role and environmentally friendly characteristic. Considering the antimicrobial activity of propolis as well as the broad‐spectrum antibacterial effects of silver nanoparticles, this study aim to describe the use of Brazilian propolis to synthesize silver nanoparticles (AgNP‐P) and investigate its antimicrobial activity. The synthesis was optimized by factorial design, choosing the best conditions for smaller size particles. AgNP‐P demonstrated a maximum absorbance at 412 nm in ultraviolet‐visible spectra, which indicated a spherical format and its formation. Dynamic light scattering demonstrated a hydrodynamic size of 109 nm and polydispersity index less than 0.3, showing a good size distribution and stability. After its purification via centrifugation, microscopy analysis corroborates the format and showed the presence of propolis around silver nanoparticle. X‐ray diffraction peaks were attributed to the main planes of the metallic silver crystalline structure; meanwhile infrared spectroscopy demonstrated the main groups responsible for silver reduction, represented by ∼22% of AgNP‐P indicates by thermal analysis. Our product revealed an important antimicrobial activity indicating a synergism between propolis and silver nanoparticles as expected and promising to be an effective antimicrobial product to be used in infections.

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“…Corrêa, Schanuel, Moura‐Nunes, Monte‐Alto‐Costa, and Daleprane () studied the effect of red propolis oral administration on inflammation and wound healing in mice, using a tissue repair model. After propolis administration, it was observed that treated group presented faster wound closure, with less neutrophils and macrophages in tissue analysis and reduced inflammatory cytokine production (TGF‐β, TNF‐α, and IL‐6).…”

Section: Propolismentioning

confidence: 99%

“…After propolis administration, it was observed that treated group presented faster wound closure, with less neutrophils and macrophages in tissue analysis and reduced inflammatory cytokine production (TGF‐β, TNF‐α, and IL‐6). Their findings suggest a positive role of red propolis oral administration in suppressing the inflammatory response during tissue repair, acting in the wound healing process (Corrêa et al, ).…”

Section: Propolismentioning

confidence: 99%

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Natural actives for wound healing: A review

Ataide

Cefali

Croisfelt

et al. 2018

Phytotherapy Research

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Nature has been a source of medicinal treatments for thousands of years, with the use of plants as prototypes for drug development and for the extraction of active compounds. Skin injuries occur regularly in everyday life, and the human skin has the ability to promote repair spontaneously under healthy conditions. However, some intrinsic and external factors may interfere with skins' natural ability, leading to nonhealing lesions and chronic wounds, which directly affect health and quality of life. Thus, attention should be given to this health problem, using an appropriated management when necessary. In this scenario, phytotherapy may be an option for cutaneous wound treatment, although further high-quality studies are needed to firmly establish the clinical efficacy of plants. This article reviews traditionally used natural actives for wound healing, highlighting their characteristics and mode of action.

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Brazilian red propolis improves cutaneous wound healing suppressing inflammation-associated transcription factor NFκB

Cited by 65 publications

References 46 publications

Effect of propolis on preserving human periodontal ligament cells and regulating pro‐inflammatory cytokines

Effect of propolis on preserving human periodontal ligament cells and regulating pro‐inflammatory cytokines

Biogenic synthesis of silver nanoparticles using Brazilian propolis

Natural actives for wound healing: A review

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