2013
DOI: 10.1016/j.cell.2013.01.003
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Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment

Abstract: Summary Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner, yet little is known about their roles in lineage commitment. Here, we identified Braveheart (Bvht), a heart-associated lncRNA in mouse. Using multiple embryonic stem cell (ESC) differentiation strategies, we show that Bvht is required for progression of nascent mesoderm towards a cardiac fate. We find that Bvht is necessary for activation of a core cardiovascular gene network and functions upstream of MesP1 (mesoderm po… Show more

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Cited by 853 publications
(755 citation statements)
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“…LncRNAs, a class of non‐coding RNAs with a length greater than 200 nt, can be involved in genetic regulation transcriptionally and post‐transcriptionally, and some of them, including Bvrt, Fendrr, ANRIL, MIAT, MyHeart (Mhrt), functioned essentially in the occurrence of heart diseases, including myocardial infarction, cardiomyopathy, heart failure and atherosclerosis 23, 24, 25, 26, 27, 28. ANRIL was a 3.8‐kb‐long non‐coding RNA transcribed from chromosome 9p21, which was a crucial locus of genetic sensitivity for CAD 29, 30.…”
Section: Discussionmentioning
confidence: 99%
“…LncRNAs, a class of non‐coding RNAs with a length greater than 200 nt, can be involved in genetic regulation transcriptionally and post‐transcriptionally, and some of them, including Bvrt, Fendrr, ANRIL, MIAT, MyHeart (Mhrt), functioned essentially in the occurrence of heart diseases, including myocardial infarction, cardiomyopathy, heart failure and atherosclerosis 23, 24, 25, 26, 27, 28. ANRIL was a 3.8‐kb‐long non‐coding RNA transcribed from chromosome 9p21, which was a crucial locus of genetic sensitivity for CAD 29, 30.…”
Section: Discussionmentioning
confidence: 99%
“…For example, HI-LNC25, a β cell-specific lncRNA, is dysregulated in type 2 diabetes, due to the down-regulation of the Kruppel-like zinc finger transcription factor (GLIS3) mRNA [19]. Braveheart (Bvht), a heart-associated lncRNA, is required for the progression of nascent mesoderm toward a cardiac fate [20]. One hundred and seventy-five lncRNAs are specifically regulated during adipogenesis [21].…”
Section: Introductionmentioning
confidence: 99%
“…Braveheart, a novel lncRNA, has been defined to be a critical regulator of cardiovascular commitment from embryonic stem cells (ESCs). 7,8 Mechanistically, braveheart mediates the epigenetic regulation of cardiac commitment by interacting with SUZ12, a component of the polycomb repressive complex 2 (PRC2). 7,9 Fendrr, another novel cardiac lncRNA, has been shown to be an essential regulator of heart and body wall development.…”
Section: Introductionmentioning
confidence: 99%
“…7,8 Mechanistically, braveheart mediates the epigenetic regulation of cardiac commitment by interacting with SUZ12, a component of the polycomb repressive complex 2 (PRC2). 7,9 Fendrr, another novel cardiac lncRNA, has been shown to be an essential regulator of heart and body wall development. 8,10 Most recently, several studies have documented that expression and function of lncRNAs are associated with a variety of cardiovascular conditions.…”
Section: Introductionmentioning
confidence: 99%