Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy

Huang, Zeping; Ding, Yan; Chen, Jinghai; Wu, Gengze; Kataoka, Masaharu; Hu, Yu‐Chen; Yang, Jian; Liu, Jianming; Drakos, Stavros G.; Selzman, Craig H.; Kyselovič, Ján; Qu, Liang; Remedios, Cristobal G. dos; Pu, William T.; Wang, Da Zhi

doi:10.1093/cvr/cvw201

Cited by 65 publications

(45 citation statements)

References 39 publications

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“…[79]. Furthermore, through gain and loss of function investigations, cardiac fibroblast-enriched lncRNAs n379599, n379519, n384648, n380433 and n410105 are indicated to participate in the TGF-β signaling pathway to regulate the fibrosis related genes expression in ischemic cardiomyopathy [80]. At the late stage of diabetes, hearts undergo hypertrophy and other remodeling events, which lead to heart dysfunction and failure eventually.…”

Section: Lncrnas and Cardiac Remodelingmentioning

confidence: 99%

The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling

Gao

Wang

et al. 2017

IJMS

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Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. Studies show that ncRNAs are not only involved in cell proliferation, apoptosis, differentiation, metabolism and other physiological processes, but also involved in the pathogenesis of diseases. Cardiac remodeling is the main pathological basis of a variety of cardiovascular diseases. Many studies have shown that the occurrence and development of cardiac remodeling are closely related with the regulation of ncRNAs. Recent research of ncRNAs in heart disease has achieved rapid development. Thus, we summarize here the latest research progress and mainly the molecular mechanism of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), in cardiac remodeling, aiming to look for new targets for heart disease treatment.

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Section: Lncrnas and Cardiac Remodelingmentioning

confidence: 99%

The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling

Gao

Wang

et al. 2017

IJMS

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“…The SHB provided LV samples from patients with ischemic heart disease (IHD) and healthy age-matched donor hearts to investigate whether IHD is associated with changes in RNA splicing of sarcomeric protein genes (Kong et al 2010). Using deep RNA sequencing, they showed that long non-coding RNA (lncRNA) is differentially regulated (Huang et al 2016). Their genome-wide transcriptome analysis confirmed that many genes, previously known to be involved in heart failure, were altered in IHD.…”

Section: Coronary Artery Diseasementioning

confidence: 99%

“…Thus, several years passed before it was discovered (Krüger et al 2009;Hamdani et al 2013;Koetter et al 2013) that the titin in our donors were indeed free of proteolysis. RNAs are also highly sensitive to hydrolysis, but several colleagues have used LV samples from failing and donors with good results including Kuster et al (2013), Kong et al (2010) and Huang et al (2016).…”

Section: Donor Heartsmentioning

confidence: 99%

The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease

Remedios

Lal

et al. 2017

Biophys Rev

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The Sydney Heart Bank (SHB) is one of the largest human heart tissue banks in existence. Its mission is to provide high-quality human heart tissue for research into the molecular basis of human heart failure by working collaboratively with experts in this field. We argue that, by comparing tissues from failing human hearts with age-matched non-failing healthy donor hearts, the results will be more relevant than research using animal models, particularly if their physiology is very different from humans. Tissue from heart surgery must generally be used soon after collection or it significantly deteriorates. Freezing is an option but it raises concerns that freezing causes substantial damage at the cellular and molecular level. The SHB contains failing samples from heart transplant patients and others who provided informed consent for the use of their tissue for research. All samples are cryopreserved in liquid nitrogen within 40 min of their removal from the patient, and in less than 5-10 min in the case of coronary arteries and left ventricle samples. To date, the SHB has collected tissue from about 450 failing hearts (>15,000 samples) from patients with a wide range of etiologies as well as increasing numbers of cardiomyectomy samples from patients with hypertrophic cardiomyopathy. The Bank also has hearts from over 120 healthy This article is part of a Special Issue on 'IUPAB Edinburgh Congress' edited by Damien Hall.Electronic supplementary material The online version of this article

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“…Fu et al [29] observed that TGF-βRII and SMAD2 could be upregulated by ectopic expression of lncRNA-ATB in hepatic stellate cells. Huang et al [30] found that lncRNA participate in the TGF-β pathway to modulate the expression of ECM genes and myofibroblast differentiation. Zhao et al [31] suggested that TGF-β/Smad signaling is inhibited by lncRNA-ANRL, which then resulted in reduced p15INK4B expression.…”

Section: Discussionmentioning

confidence: 99%

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts

Zheng

Peng

et al. 2017

Skin Pharmacol Physiol

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Background: Long noncoding RNA (lncRNA) are differentially expressed across stages of differentiation and development, but the role of lncRNA in human skin photoaging mechanisms remains poorly understood. Objective: This study aimed to determine lncRNA expression changes in human dermal fibroblasts (HDF) induced by repeated UVA irradiation and to explore correlations between lncRNA and skin photoaging prognosis. Methods: In the UVA-HDF group, HDF were subjected to repeated UVA irradiation (10 J/cm² UVA twice daily for 7 days); in the control group, HDF received no irradiation. High-throughput sequencing was used to detect lncRNA expression profiles. Functional annotation analysis and pathway enrichment were preformed via Gene Ontology and KEGG. Predicted lncRNA target genes were identified by bioinformatic analysis. Results: In the UVA-HDF group, 1,730 lncRNA exhibited over 2-fold expression changes compared with the control group: 1,494 were upregulated, and 236 downregulated. Predicted lncRNA targets were associated with matrix metalloproteinases, cathepsin D, mitogen-activated protein kinase and TGF-β signaling pathways, and collagen fiber metabolism following repeated UVA damaging mechanisms. Conclusions: lncRNA profiles were aberrantly expressed in UVA-HDF and might play a key role in skin photoaging. This study provides novel insights into the repeated UVA-damaging pathology and potential targets for treatment of human skin photoaging.

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Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy

Cited by 65 publications

References 39 publications

The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling

The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling

The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts

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