Branchial elimination of superhydrophobic organic compounds by rainbow trout (Oncorhynchus mykiss)

Fitzsimmons, Patrick N.; Fernandez, Joseph D.; Hoffman, Alex D.; Butterworth, Brian C.; Nichols, John W.

doi:10.1016/s0166-445x(01)00174-6

Cited by 125 publications

(125 citation statements)

References 24 publications

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“…In an effort to interpret observations from the present study across the equipotent treatment levels (Fig. 5), we employed a fish plasma uptake modeling approach (10,26,47) to predict internal doses of DPH of zebrafish in Fig. 5 using Eq.…”

Section: Discussionmentioning

confidence: 99%

Comparative Pharmacology and Toxicology of Pharmaceuticals in the Environment: Diphenhydramine Protection of Diazinon Toxicity in Danio rerio but Not Daphnia magna

Kristofco

Chambliss

et al. 2014

AAPS J

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Abstract. Pharmaceuticals and other contaminants of emerging concern present unique challenges to environmental risk assessment and management. Fortunately, mammalian pharmacology and toxicology safety data are more readily available for pharmaceuticals than other environmental contaminants. Identifying approaches to read-across such pharmaceutical safety information to non-target species represents a major research need to assess environmental hazards. Here, we tested a biological readacross hypothesis from emergency medicine with common aquatic invertebrate and vertebrate models. In mammals, the antihistamine diphenhydramine (DPH) confers protection from poisoning by acetylcholinesterase inhibition because DPH blocks the acetylcholine receptor. We employed standardized toxicity methods to examine individual and mixture toxicity of DPH and the acetylcholinesterase inhibitor diazinon (DZN) in Daphnia magna (an invertebrate) and Danio rerio (zebrafish, a vertebrate). Though the standardized Fish Embryo Toxicity method evaluates early life stage toxicity of zebrafish (0-3 days post fertilization, dpf), we further evaluated DPH, DZN, and their equipotent mixture during three development stages (0-3, 3-6, 7-10 dpf) in zebrafish embryos. Independent action and concentration addition mixture models and fish plasma modeling were used to assist interpretation of mixture toxicity experiments. Though our primary hypothesis was not confirmed in acute studies with Daphnia magna, DPH conferred a protective effect for acute DZN toxicity to zebrafish when DPH plasma levels were expected to be greater than mammalian therapeutic, but lower than acutely lethal, internal doses. We further observed that timing of developmental exposure influenced the magnitude of DZN and DPH toxicity to zebrafish, which suggests that future zebrafish toxicity studies with pharmaceuticals and pesticides should examine exposure during developmental stages.KEY WORDS: alternative toxicity test methods; biological read-across; comparative pharmacology and toxicology; mixture toxicology; pharmaceuticals in the environment.

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Section: Discussionmentioning

confidence: 99%

Comparative Pharmacology and Toxicology of Pharmaceuticals in the Environment: Diphenhydramine Protection of Diazinon Toxicity in Danio rerio but Not Daphnia magna

Kristofco

Chambliss

et al. 2014

AAPS J

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“…(c) Therapeutic hazards of surface water quality Predicted P BW values for each target analyte in fish plasma were generated using a previously reported physiological-based pharmacokinetic model, which derived an empirical relationship (equation (2.1)) to model branchial flux of organic chemicals across a wide range of log K ow values from 0 to 8 [25]. Additionally, we modified equation (2.1) and substituted octanol -water distribution coefficient (D ow ) and liposome-water distribution coefficient (D lipw ) in equations (2.2) and (2.3), respectively log P BW ¼ log ( (10 0 …”

Section: Materials and Methods (A) Study Site And Field Samplingmentioning

confidence: 99%

Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream

Haddad

Luek

et al. 2014

Phil. Trans. R. Soc. B

123

114

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Though pharmaceuticals are increasingly observed in a variety of organisms from coastal and inland aquatic systems, trophic transfer of pharmaceuticals in aquatic food webs have not been reported. In this study, bioaccumulation of select pharmaceuticals was investigated in a lower order effluent-dependent stream in central Texas, USA, using isotope dilution liquid chromatography–tandem mass spectrometry (MS). A fish plasma model, initially developed from laboratory studies, was tested to examine observed versus predicted internal dose of select pharmaceuticals. Pharmaceuticals accumulated to higher concentrations in invertebrates relative to fish; elevated concentrations of the antidepressant sertraline and its primary metabolite desmethylsertraline were observed in the Asian clam, Corbicula fluminea , and two unionid mussel species. Trophic positions were determined from stable isotopes (δ 15 N and δ 13 C) collected by isotope ratio-MS; a Bayesian mixing model was then used to estimate diet contributions towards top fish predators. Because diphenhydramine and carbamazepine were the only target compounds detected in all species examined, trophic magnification factors (TMFs) were derived to evaluate potential trophic transfer of both compounds. TMFs for diphenhydramine (0.38) and carbamazepine (1.17) indicated neither compound experienced trophic magnification, which suggests that inhalational and not dietary exposure represented the primary route of uptake by fish in this effluent-dependent stream.

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“…Despite its limitations, the Huggett Model appears to provide a reasonable screening approach that is amenable to further refinement. Remaining to be determined is whether: (i) a relationship similar to the equation of Fitzsimmons et al (2001) (Equation 8.3) would be appropriate for ionizable APIs if, for example, log Kow were substituted with log D; (ii) dietary exposure is a concern for specific APIs; (iii) clearance rates could be predicted in fish using mammalian or target organism information and allometric scaling approaches (if the metabolic pathway for eliminating an APT [e.g., CYP450 isoenzyme] is present in a study species); or (iv) API target densities and functional responses would be different between mammals and fish. Similar approaches have not been developed for other organisms (e.g., invertebrates).…”

Section: The Huggett Modelmentioning

confidence: 99%

Organic Contaminants in Marine Mammals

Loseto¹,

Ross²

2011

Environmental Contaminants in Biota

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Branchial elimination of superhydrophobic organic compounds by rainbow trout (Oncorhynchus mykiss)

Cited by 125 publications

References 24 publications

Comparative Pharmacology and Toxicology of Pharmaceuticals in the Environment: Diphenhydramine Protection of Diazinon Toxicity in Danio rerio but Not Daphnia magna

Comparative Pharmacology and Toxicology of Pharmaceuticals in the Environment: Diphenhydramine Protection of Diazinon Toxicity in Danio rerio but Not Daphnia magna

Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream

Organic Contaminants in Marine Mammals

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