Branchial Cleft Carcinoma

Katubig, Cornelio; Damjanov, Ivan

doi:10.1001/archotol.1969.00770020752014

Archives of Otolaryngology - Head and Neck Surgery

1969

DOI: 10.1001/archotol.1969.00770020752014

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Branchial Cleft Carcinoma

Cornelio Katubig¹,

Ivan Damjanov²

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1973

1992

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Cited by 18 publications

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“…More recent reports tend to minimize the importance of Martin's third criterion of 5year follow-up without identification of a primary tumor e l~e w h e r e , '~>~~,~~ many of these patients will die before the 5-year period has elapsed; a significant number of patients will receive postoperative radiotherapy that could presumably control an occult primary, such that an occult primary cannot be ruled out even after a 5-year follow-up period. Instead, more reliance is being placed on two additional criteria: 12,17,20,22,[25][26][27][28][29][30][31] .…”

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confidence: 99%

Primary branchiogenic carcinoma

Khafif

Minkowitz

1989

Head & Neck

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An extensive historical review of branchial cleft cyst carcinoma is undertaken and a critical analysis of all 67 cases reported in the English literature since Martin's landmark report is carried out and tabulated. Forty-one of the 67 cases were definitely ruled out as carcinomas of branchial cysts. Though only eight of the remaining 26 cases satisfied Martin's criterion of 5-year follow-up without evidence of primary carcinoma elsewhere, 14 patients had incontrovertible evidence of branchiogenic carcinoma, evidenced by a branchial cyst with histologic evidence of epithelial dysplasia progressing to squamous cell carcinoma within the cyst wall. Two previously unreported cases are presented. A therapeutic approach including wide local excision, radical neck dissection, and radiotherapy is recommended. A more thorough search for an occult head and neck primary, and a clearer understanding of the histopathology of branchiogenic carcinoma, are suggested as alternate requirements for this diagnosis.

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