2024
DOI: 10.1016/j.freeradbiomed.2023.11.002
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Branched-chain amino acid catabolic defect in vascular smooth muscle cells drives thoracic aortic dissection via mTOR hyperactivation

Liming Yu,
Tao Huang,
Jikai Zhao
et al.
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Cited by 5 publications
(2 citation statements)
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“…Such a phenotypic switch of vascular smooth muscle cells could be related to metabolic reprogramming. For example, metabolic reprogramming of VSMCs was suggested to play a critical role in the pathogenesis of thoracic aortic dissection involving mitochondrial ROS damage and altered mTOR signalling [ 42 ]. Further studies are needed to understand better the metabolic mechanisms underlying the phenotypic switch in VSMCs that contribute to age-dependent arterial stiffness and remodelling and to uncover the details of the metabolic reprogramming detected here as functional impairment of respiratory and glycolytic reserve associated with NAD deficiency [ 43 45 ].…”
Section: Discussionmentioning
confidence: 99%
“…Such a phenotypic switch of vascular smooth muscle cells could be related to metabolic reprogramming. For example, metabolic reprogramming of VSMCs was suggested to play a critical role in the pathogenesis of thoracic aortic dissection involving mitochondrial ROS damage and altered mTOR signalling [ 42 ]. Further studies are needed to understand better the metabolic mechanisms underlying the phenotypic switch in VSMCs that contribute to age-dependent arterial stiffness and remodelling and to uncover the details of the metabolic reprogramming detected here as functional impairment of respiratory and glycolytic reserve associated with NAD deficiency [ 43 45 ].…”
Section: Discussionmentioning
confidence: 99%
“…Differentially expressed genes (DEGs) were identified using the ‘limma’ package (absolute Log 2 FC value greater than 0.263, a p ‐value <0.05). 21 We performed GO and KEGG pathway enrichment analyses for these DEGs using the Metascape bioinformatics resources ( http://metascape.org , version 3.5.20230501).…”
Section: Methodsmentioning
confidence: 99%