Functional deterioration of vascular mitochondrial and glycolytic capacity in the aortic rings of aged mice
Agnieszka Karaś,
Anna Bar,
Kanchana Pandian
et al.
Abstract:Vascular ageing is associated with increased arterial stiffness and cardiovascular mortality that might be linked to altered vascular energy metabolism. The aim of this study was to establish a Seahorse XFe96 Analyzer-based methodology for the reliable, functional assessment of mitochondrial respiration and glycolysis in single murine aortic rings and to validate this functional assay by characterising alterations in vascular energy metabolism in aged mice. Healthy young and old C57BL/6 mice were used for the … Show more
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