Brainstem response amplitudes in neonatal chronic lung disease and differences from perinatal asphyxia

Jiang, Ze D.; Brosi, Dorothea M.; Chen, C.; Wilkinson, A

doi:10.1016/j.clinph.2009.02.166

Cited by 14 publications

(12 citation statements)

References 30 publications

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“…These are associated with myelination and synaptic function in the brainstem or central auditory pathway (28,32). We observed a significant increase both in the I-V and in the III-V intervals, although the increase in the III-V interval was larger than that of the I-III interval.…”

Section: Discussionmentioning

confidence: 55%

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

et al. 2015

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Maturation of the auditory pathway is dependent on the central nervous system myelination and it can be affected by pathologies such as neonatal hypoxic ischemic (HI) encephalopathy. Our aim was to evaluate the functional integrity of the auditory pathway and to visualize, by histological and cellular methods, the damage to the brainstem using a neonatal rat model of HI brain injury. To carry out this morphofunctional evaluation, we studied the effects of the administration of the antioxidants nicotine, melatonin, resveratrol and docosahexaenoic acid after hypoxia-ischemia on the inferior colliculus and the auditory pathway. We found that the integrity of the auditory pathway in the brainstem was altered as a consequence of the HI insult. Thus, the auditory brainstem response (ABR) showed increased I-V and III-V wave latencies. At a histological level, HI altered the morphology of the inferior colliculus neurons, astrocytes and oligodendricytes, and at a molecular level, the mitochondria membrane potential and integrity was altered during the first hours after the HI and reactive oxygen species (ROS) activity is increased 12 h after the injury in the brainstem. Following antioxidant treatment, ABR interpeak latency intervals were restored and the body and brain weight was recovered as well as the morphology of the inferior colliculus that was similar to the control group. Our results support the hypothesis that antioxidant treatments have a protective effect on the functional changes of the auditory pathway and on the morphological damage which occurs after HI insult.

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Section: Discussionmentioning

confidence: 55%

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

et al. 2015

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“…For example, we have recently found that the response changes in infants with neonatal chronic lung disease are quite different from those after perinatal asphyxia. 12,13,15,19 Data from the present study indicate that although the response changes were generally less specific in differentiation of the etiology and classification of cerebral palsy, there were some characteristic changes in the brainstem auditory evoked responses in certain etiologies. For instance, a significant reduction in wave V amplitude was seen mainly in the children with cerebral palsy after asphyxia.…”

Section: Brainstem Auditory Evoked Response Changes In Cerebral Palsymentioning

confidence: 55%

“…The present study found that the major response changes in cerebral palsy were waveform depression and amplitude reduction of later waves, typically wave V. These changes reflect mainly a decrease in the amount, or synchronization of neural activity in the auditory brainstem, resulting in a depressed auditory electrophysiology. 12,[17][18][19] This condition may be related to or caused by the neuropathology underlying or associated with cerebral palsy. It appears that neuropathology has a major effect on neural generator of the amplitudes of response components, resulting in a depression of brainstem auditory electrophysiology.…”

Section: Brainstem Auditory Evoked Response Changes In Cerebral Palsymentioning

confidence: 99%

“…This result supports our previous claim that compared with the V/I amplitude ratio, the amplitude of wave V is a more sensitive and reliable response variable in reflecting brainstem auditory function in some clinical settings. [17][18][19][20] In brainstem auditory evoked response waveform, waves II and IV are relatively variable and less reliable, compared with the major waves I, III, and V. Even in healthy children, the 2 waves are usually not as robust as those major waves, which may imply that the summed potentials contributing to the 2 response waves are smaller or weaker than those contributing to waves I, III, and V. One of the major abnormalities in our children with cerebral palsy was a poor identification of some response waves, often with missing waves. The missing waves occurred mainly in waves II and IV.…”

Section: Brainstem Auditory Evoked Response Changes In Cerebral Palsymentioning

confidence: 99%

“…In this study, the major mechanism underlying the persistent reduction of wave V amplitude in children with cerebral palsy resulting from asphyxia is most likely the result of fewer generating neurons and/or fewer fibers conducting the volley in the generators of wave V following hypoxic-ischemic insults. 18,19 Brainstem Auditory Evoked Responses in Reflecting Neuropathology Underlying or Associated With Cerebral Palsy…”

Section: Brainstem Auditory Evoked Response Changes In Cerebral Palsymentioning

confidence: 99%

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Depressed Brainstem Auditory Function in Children With Cerebral Palsy

Jiang

Liu

et al. 2010

J Child Neurol

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Brainstem auditory evoked responses were studied to examine brainstem auditory function in 80 children with cerebral palsy. The response waveform, particularly later waves, tended to be depressed. Thirty-three (41.3%) showed abnormal results. The main abnormality was reduced wave V amplitude. Other abnormalities were decreased V/I amplitude ratio, missing waves, prolonged I-V interval, and increased interaural difference in I-V interval. The abnormalities were persistent during the follow-up. In contrast to common findings in the responses in progressive neurologies, abnormalities in interpeak intervals were rare in children with cerebral palsy. There were some characteristic changes in the responses in certain etiologies. These results suggest that brainstem auditory function in children with cerebral palsy is depressed, which may be owing to decreased or altered neural firing or synchrony in the auditory brainstem. A detailed analysis of central components of the responses is valuable in detecting central auditory dysfunction in children with cerebral palsy.

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Hearing disorders in brainstem lesions

Celesia

2015

Handbook of Clinical Neurology

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Brainstem response amplitudes in neonatal chronic lung disease and differences from perinatal asphyxia

Cited by 14 publications

References 30 publications

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

Depressed Brainstem Auditory Function in Children With Cerebral Palsy

Hearing disorders in brainstem lesions

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