Brainstem networks: Reticulocortical synchronization

Faingold, Carl L.

doi:10.1111/j.1528-1167.2010.02812.x

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Evidence for the role of the brainstem as a seizure generator in convulsive disorders has been derived largely using circumscribed lesions and transections of the adult mammalian brainstem, as well as from human electroencephalography (EEG) recordings. 5,9,14,15 Little is known in this regard about the immature brain [16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

Forebrain‐independent generation of hyperthermic convulsions in infant rats

et al. 2015

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SummaryFebrile seizures are the most common type of convulsive events in children. It is generally assumed that the generalization of these seizures is a result of brainstem invasion by the initial limbic seizure activity. Using precollicular transection in 13‐day‐old rats to isolate the forebrain from the brainstem, we demonstrate that the forebrain is not required for generation of tonic–clonic convulsions induced by hyperthermia or kainate. Compared with sham‐operated littermate controls, latency to onset of convulsions in both models was significantly shorter in pups that had undergone precollicular transection, indicating suppression of the brainstem seizure network by the forebrain in the intact animal. We have shown previously that febrile seizures are precipitated by hyperthermia‐induced respiratory alkalosis. Here, we show that triggering of hyperthermia‐induced hyperventilation and consequent convulsions in transected animals are blocked by diazepam. The present data suggest that the role of endogenous brainstem activity in triggering tonic–clonic seizures should be re‐evaluated in standard experimental models of limbic seizures. Our work sheds new light on the mechanisms that generate febrile seizures in children and, therefore, on how they might be treated.

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Section: Discussionmentioning

confidence: 99%

Forebrain‐independent generation of hyperthermic convulsions in infant rats

et al. 2015

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“…Importantly, brain stem changes were transient and could not be observed at later timepoints. They may be related to the mechanisms underlying generalized seizure induction given the role of the reticular formation in tonic-clonic seizures generation [36,37], but also to the enhancement of serotonergic and dopaminergic neurotransmission observed after ECS/ECT [8].…”

Section: Discussionmentioning

confidence: 99%