Brain-Wide Maps of Synaptic Input to Cortical Interneurons

Wall, Nicholas R.; Parra, Mauricio De La; Sorokin, Jordan M.; Taniguchi, Hiroki; Huang, Zirui; Callaway, Edward M.

doi:10.1523/jneurosci.3967-15.2016

Cited by 152 publications

(183 citation statements)

References 32 publications

Supporting

Mentioning

158

Contrasting

Order By: Relevance

“…PV+, SST+, and VIP+ neurons all receive long-range inputs from other cortical and subcortical areas that serve a range of important functions, including feed-forward inhibition and feedback disinhibition (Kepecs and Fishell, 2014; Wall et al, 2016). Therefore, we focused on circuit responses to external inputs driving the three interneuron cell types, starting with inputs targeting the PV+ populations.…”

Section: Resultsmentioning

confidence: 99%

“…Long-range feedforward inputs strongly target PV+ neurons, while long-range feedback inputs tend to target VIP+ neurons, which in turn inhibit SST+ neurons (Pfeffer et al, 2013; Pi et al, 2013; Wall et al, 2016). As a result of a high PV+/SST+ ratio, excitatory neurons in the motor somatosensory areas will have a stronger response to feedforward inhibition.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism

Kim

Yang

Pradhan

et al. 2017

Cell

Self Cite

337

530

View full text Add to dashboard Cite

SUMMARY The stereotyped features of neuronal circuits are those most likely to explain the remarkable capacity of the brain to process information and govern behaviors, yet it has not been possible to comprehensively quantify neuronal distributions across animals or genders due to the size and complexity of the mammalian brain. Here we apply our quantitative brain-wide (qBrain) mapping platform to document the stereotyped distributions of mainly inhibitory cell types. We discover an unexpected cortical organizing principle: sensory-motor areas are dominated by output-modulating parvalbumin-positive interneurons, whereas association, including frontal, areas are dominated by input-modulating somatostatin-positive interneurons. Furthermore, we identify local cell type distributions with more cells in the female brain in seven out of eight sexually dimorphic subcortical areas, in contrast to the overall larger brains in males. The qBrain resource can be further mined to link stereotyped aspects of neuronal distributions to known and unknown functions of diverse brain regions.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism

Kim

Yang

Pradhan

et al. 2017

Cell

Self Cite

337

530

View full text Add to dashboard Cite

show abstract

“…Cortico‐cortical connections to and from each single cortical neuron can be incredibly widespread (Wall et al . ; Gerfen et al . ; Lin et al .…”

Section: Discussionmentioning

confidence: 99%

“…Recent neuroanatomical evidence suggests that the neocortex may be even more tightly interconnected. Cortico-cortical connections to and from each single cortical neuron can be incredibly widespread (Wall et al 2016;Gerfen et al 2018;Lin et al 2018;Economo et al 2019). Moreover, activity generated in one part of the cortex can in principle reach any other part of the cortex via a single synaptic relay in the thalamus (Sherman, 2016).…”

Section: Changing Views On the Organization Of Cortical Processingmentioning

confidence: 99%

Focal neocortical lesions impair distant neuronal information processing

Wahlbom¹,

Enander²,

Bengtsson³

et al. 2019

The Journal of Physiology

View full text Add to dashboard Cite

Key points Parts of the fields of neuroscience and neurology consider the neocortex to be a functionally parcelled structure. Viewed through such a conceptual filter, there are multiple clinical observations after localized stroke lesions that seem paradoxical. We tested the effect that localized stroke‐like lesions have on neuronal information processing in a part of the neocortex that is distant to the lesion using animal experiments. We find that the distant lesion degrades the quality of neuronal information processing of tactile input patterns in primary somatosensory cortex. The findings suggest that even the processing of primary sensory information depends on an intact neocortical network, with the implication that all neocortical processing may rely on widespread interactions across large parts of the cortex. Abstract Recent clinical studies report a surprisingly weak relationship between the location of cortical brain lesions and the resulting functional deficits. From a neuroscience point of view, such findings raise questions as to what extent functional localization applies in the neocortex and to what extent the functions of different regions depend on the integrity of others. Here we provide an in‐depth analysis of the changes in the function of the neocortical neuronal networks after distant focal stroke‐like lesions in the anaesthetized rat. Using a recently introduced high resolution analysis of neuronal information processing, consisting of pre‐set spatiotemporal patterns of tactile afferent activation against which the neuronal decoding performance can be quantified, we found that stroke‐like lesions in distant parts of the cortex significantly degraded the decoding performance of individual neocortical neurons in the primary somatosensory cortex (decoding performance decreased from 30.9% to 24.2% for n = 22 neurons, Wilcoxon signed rank test, P = 0.028). This degrading effect was not due to changes in the firing frequency of the neuron (Wilcoxon signed rank test, P = 0.499) and was stronger the higher the decoding performance of the neuron, indicating a specific impact on the information processing capacity in the cortex. These findings suggest that even primary sensory processing depends on widely distributed cortical networks and could explain observations of focal stroke lesions affecting a large range of functions.

show abstract

“…Vasoactive intestinal peptide (VIP) expressing cells comprise a major class of inhibitory neurons and are well-positioned to mediate top-down influences on local circuits in sensory cortex. VIP cells receive long-range projections from frontal areas Wall et al, 2016;Zhang and Dan, 2014) as well as cholinergic and noradrenergic inputs (Alitto and Dan, 2013;Fu et al, 2014). VIP cells are highly active during states of arousal (Reimer et al, 2014), are modulated by running (Fu et al, 2014;Reimer et al, 2014) and task engagement (Kuchibhotla et al, 2017), and are responsive to behavioral reinforcement (Pi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Experience shapes activity dynamics and stimulus coding of VIP inhibitory and excitatory cells in visual cortex

Garrett

Manavi

Roll

et al. 2019

Preprint

View full text Add to dashboard Cite

Cortical circuits are flexible and can change with experience and learning. However, the effects of experience on specific cell types including distinct inhibitory types are not well understood. Here we studied how excitatory and VIP inhibitory cells in layer 2/3 of mouse visual cortex were impacted by visual experience in the context of a behavioral task. Mice learned to perform an image change detection task with a set of eight natural scene images. Subsequently, during 2-photon imaging experiments, mice performed the task with these familiar images and three additional sets of novel images. Familiar images evoked less overall activity in both excitatory and VIP populations, and excitatory cells showed higher selectivity for familiar images. The temporal dynamics of VIP cells differed markedly between novel and familiar images: VIP cells were stimulus-driven for novel images but displayed ramping activity during the inter-stimulus interval for familiar images. Moreover, when a familiar stimulus was omitted, VIP cells showed extended ramping activity until the subsequent image flash. This prominent shift in response dynamics suggests that VIP cells may adopt different modes of processing during familiar versus novel conditions. HIGHLIGHTS• Experience with natural images in a change detection task reduces overall activity of cortical excitatory and VIP inhibitory cells • Encoding of natural images is sharpened with experience in excitatory neurons • VIP cells are stimulus-driven by novel images but show pre-stimulus ramping for familiar images • VIP cells show strong ramping activity during the omission of an expected stimulus RESULTS Visual change detection task with familiar and novel imagesWe trained GCaMP6f-expressing transgenic mice to perform a go/no-go visual change detection task with natural scene stimuli ( Figure 1A). In this task, mice are presented with a continuous stream of flashing stimuli (250 ms image flash separated by 500 ms gray screen; Figure 1B). On 'go' trials, a change in image identity occurs at a time unknown to the animal. To earn water rewards, mice must report the image change by licking a reward spout within a 750 ms response window. False alarms are quantified during 'catch' trials in which the repeated image does not change, but licking behavior is measured in a similar time window ( Figure 1B; see Methods). Behavioral training proceeded through a series of stages: mice first learned task rules with simple full-field gratings of two different orientations with no intervening gray period, followed by introduction of a 500ms gray screen period between grating flashes, and lastly, training of natural scene stimuli ( Figure 1C). During the natural image stage, mice were trained with one set of eight images (image set A) for an extended number of sessions (range = 6-46 sessions with image set A, median = 17 sessions; Figure 1F, Supplemental Figure 1A). Mice viewed each of the eight scenes from the familiar image set an average of 10,350 times prior to the 2-photon imaging stage (range: ...

show abstract

Brain-Wide Maps of Synaptic Input to Cortical Interneurons

Cited by 152 publications

References 32 publications

Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism

Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism

Focal neocortical lesions impair distant neuronal information processing

Experience shapes activity dynamics and stimulus coding of VIP inhibitory and excitatory cells in visual cortex

Contact Info

Product

Resources

About