Brain white-matter lesions in inflammatory bowel disease

Can the Pathophysiology of Autism be Explained by the Nature of the Discovered Urine Peptides?

“…This might explain the increased uptake of protein measured as specific IgA antibody increases in serum (Reichelt et al, 1991;Lucarelli et al, 1995;Cade et al, 2000) and increased low molecular weight permeability (D'Eufemia et al, 1996). Several papers have furthermore, established that inflammatory gut disease regularly causes white matter lesions in the brain (Geissler et al, 1995;Hart, 1998). Peptides may easily be seen to mediate such actions especially because of the opioid link also to epilepsy as outlined.…”

Manifestations neurologiques des maladies inflammatoires chroniques de l’intestin

“…Toutefois, Scheid et Teich (2007) constatent que les critè res diagnostiques actuels de la sclé rose en plaques ne sont pas toujours ré unis. En effet, des lé sions dé myé linisantes de la substance blanche asymptomatiques sont fré quemment dé crites dans les MICI (Geissler, 1995 ;Hart et al, 1998 ;Nemoto et al, 2004) ; elles se rencontrent dans 40 à 50 % des cas (Perkin et Murray-Lyon, 1998). Des tableaux rappelant l'encé phalomyé lite aiguë dissé miné e ont é galement é té rapporté s, avec certains particularité s é volutives, notamment la survenue de symptô mes et signes neurologiques sous traitement corticoïdes (Nelson et al, 1986 ;Masaki et al, 1997 ;Nemoto et al, 2004).…”

Neurological Manifestations of Inflammatory Bowel Disease

“…In fact, most of these lesions have no clinical relevance and their presence in IBD patients should not be used to infer active CNS disease [42]. Further research is needed about the origin of these lesions and their neurological and cognitive consequences in IBD patients.…”