Brain trace element concentrations in aging

Markesbery, William R.; Ehmann, W. D.; Alauddin, M.; Hossain, T. I. M.

doi:10.1016/0197-4580(84)90081-2

Cited by 216 publications

(94 citation statements)

References 28 publications

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“…We hypothesize that the marked elevations in copper and iron as a product of age could explain the age-dependent onset of amyloid neuropathology in the Tg2576 model (35,37). Studies in humans suggest that the aging human brain follows a similar pattern of age-related changes, at least for iron (13,15,17,38,39) and cobalt (40). In the following model, if the changes in metals we observed in mice are also reflected in the aging human brain, then a senescent rise in brain copper and iron could be the neurochemical basis for age being the major risk factor for AD neuropathology (41).…”

Section: Discussionmentioning

confidence: 95%

Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron

Maynard¹,

Cappai²,

Volitakis³

et al. 2002

Journal of Biological Chemistry

335

308

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Section: Discussionmentioning

confidence: 95%

Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron

Maynard¹,

Cappai²,

Volitakis³

et al. 2002

Journal of Biological Chemistry

335

308

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“…In serum, it has been documented for Cu by Ghayour-Mobarhan et al (2005) and Kouremenou-Dona et al (2006); for Se by Lopes et al (2004). In brain, Markesbery et al (1984), Ongkana et al (2010) and Tohno et al (2010)  data converted from nmol/L Table 6. Manganese in Controls and Patients (µg/L) elements.…”

Section: Agementioning

confidence: 99%

Minor and Trace Elements in Cerebrospinal Fluid of Parkinson's Patients – Suggestions After a Critical Review of the Analytical Data

Speziali¹,

Casa²

2011

Diagnostics and Rehabilitation of Parkinson's Disease

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“…This result is in good agreement with those reported by other authors, who also reported an increase in the copper levels in some areas of the brain, like the hippocampus and the temporal cortex. 21,24,25 Another neurodegenerative disorder in which copper is related is Wilson's disease. 22,26 This disease is characterized by organ and cellular copper accumulation.…”

Section: Resultsmentioning

confidence: 99%

Topographic Trace-Elemental Analysis in the Brain of Wistar Rats by X-ray Microfluorescence with Synchrotron Radiation

et al. 2008

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Knowledge about the spatial distribution and the local concentration of trace elements in tissues is of great importance, since trace elements are involved in many biological functions of living organisms. However, there are few methods available to measure the spatial (two (three)-dimensional) elemental distribution in animal brain. X-ray microfluorescence with synchrotron radiation is a multielemental mapping technique, which was used in this work to determine the topographic of iron, zinc and copper in coronal sections of female Wistar rats of different ages. Young (14 days old) and middle-aged (20 months old) rats (n = 8) were analyzed. The measurements were carried out at the XRF beam line at the Synchrotron Light National Laboratory (Campinas, Brazil). Two-dimensional scanning was performed in order to study the tendency of elemental concentration variation. The acquisition time for each pixel was 10 s/step and the step size was 300 mm/step in both directions. It was observed that the iron distribution was more conspicuous in the cortical area, thalamus and bellow the thalamus. On the other hand, the zinc distribution was more pronounced in the hippocampus. The iron, copper and zinc levels increased with advancing age. Therefore, this study reinforces the idea that these elements are involved in the chemical mechanisms of the brain that induce some neurological diseases, since they are also present in high levels in specific areas of the brain, such as the hippocampus and the substantia nigra of patients with these disorders.

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Brain trace element concentrations in aging

Cited by 216 publications

References 28 publications

Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron

Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron

Minor and Trace Elements in Cerebrospinal Fluid of Parkinson's Patients – Suggestions After a Critical Review of the Analytical Data

Topographic Trace-Elemental Analysis in the Brain of Wistar Rats by X-ray Microfluorescence with Synchrotron Radiation

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