Brain structural MRI correlates of cognitive dysfunctions in Parkinson's disease

Ibarretxe‐Bilbao, Naroa; Junqué, Carme; Martı́, Marı́a José; Tolosa, Eduardo

doi:10.1016/j.jns.2011.07.054

Cited by 82 publications

(62 citation statements)

References 41 publications

(49 reference statements)

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“…A common framework for cognitive deficits in Parkinson's disease was proposed in which fronto-subcortical executive deficits could be related to mild and stable dopaminergic deficits, whereas dementia could be associated with more widespread posterior cortical atrophy and with Lewy body deposition or plaques and cholinergic deficiency. 48 Dementia in Parkinson's disease is also associated with changes in hippocampus 49 and frontal-temporal regions. 50 Atrophy in these regions accelerates with disease progression, especially in patients who develop cognitive impairment.…”

Section: Imaging Cognitive and Behavioural Complications In Parkinsonmentioning

confidence: 99%

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Stoessl¹,

Lehericy²,

Strafella³

2014

The Lancet

141

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Recent advances in structural and functional imaging have greatly improved our ability to assess normal functions of the basal ganglia, diagnose parkinsonian syndromes, understand the pathophysiology of parkinsonism and other movement disorders, and detect and monitor disease progression. Radionuclide imaging is the best way to detect and monitor dopamine deficiency, and will probably continue to be the best biomarker for assessment of the effects of disease-modifying therapies. However, advances in magnetic resonance enable the separation of patients with Parkinson's disease from healthy controls, and show great promise for differentiation between Parkinson's disease and other akinetic-rigid syndromes. Radionuclide imaging is useful to show the dopaminergic basis for both motor and behavioural complications of Parkinson's disease and its treatment, and alterations in non-dopaminergic systems. Both PET and MRI can be used to study patterns of functional connectivity in the brain, which is disrupted in Parkinson's disease and in association with its complications, and in other basal-ganglia disorders such as dystonia, in which an anatomical substrate is not otherwise apparent. Functional imaging is increasingly used to assess underlying pathological processes such as neuroinflammation and abnormal protein Correspondence to: Prof A J Stoessl,

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Section: Imaging Cognitive and Behavioural Complications In Parkinsonmentioning

confidence: 99%

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Stoessl¹,

Lehericy²,

Strafella³

2014

The Lancet

141

View full text Add to dashboard Cite

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“…Recent evidence suggests that cognitive impairment present in the early stages of PD cannot be fully explained by dopamine depletion alone (Hanna-Pladdy, Jones, Cabanban, Pahwa, & Lyons, 2013; Tomer, Aharon-Peretz, & Tsitrinbaum, 2007). In addition to dopamine, many other contributing factors to cognitive deficits in PD have been considered including structural changes in both cortical and subcortical regions, genetic variation in the COMT gene, amyloid plaques, alpha-synuclein, tau protein, and involvement of other neurotransmitter systems including GABA (Beyer, Janvin, Larsen, & Aarsland, 2007; Braak et al, 2003; Buongiorno, Compta, & Marti, 2011; Gomperts et al, 2013; Ibarretxe-Bilbao, Junque, Marti, & Tolosa, 2011; Luciana, Collins, & Depue, 1998). Nonetheless, since therapy with levodopa has been demonstrated to modify cognition, it is critical to first clarify the role of dopamine in cognitive functioning to discriminate pathophysiological mechanisms mediating motor and nonmotor features of PD (Cools, 2006; Verreyt et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Paradoxical Effect of Dopamine Medication on Cognition in Parkinson’s Disease: Relationship to Side of Motor Onset

Hanna-Pladdy

Pahwa

Lyons

2015

J Int Neuropsychol Soc

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Parkinson's disease (PD) is characterized by asymmetric motor symptom onset attributed to greater degeneration of dopamine neurons contralateral to the affected side. However, whether motor asymmetries predict cognitive profiles in PD, and to what extent dopamine influences cognition remains controversial. This study evaluated cognitive variability in PD by measuring differential response to dopamine replacement therapy (DRT) based on hemispheric asymmetries. The influence of DRT on cognition was evaluated in mild PD patients (n = 36) with left or right motor onset symptoms. All subjects were evaluated on neuropsychological measures on and off DRT and compared to controls (n = 42). PD patients were impaired in executive, memory and motor domains irrespective of side of motor onset, although patients with left hemisphere deficit displayed greater cognitive impairment. Patients with right hemisphere deficit responded to DRT with significant improvement in sensorimotor deficits, and with corresponding improvement in attention and verbal memory functions. Conversely, patients with greater left hemisphere dopamine deficiency did not improve in attentional functions and declined in verbal memory recall following DRT. These findings support the presence of extensive mild cognitive deficits in early PD not fully explained by dopamine depletion alone. The paradoxical effects of levodopa on verbal memory were predicted by extent of fine motor impairment and sensorimotor response to levodopa, which reflects extent of dopamine depletion. The findings are discussed with respect to factors influencing variable cognitive profiles in early PD, including hemispheric asymmetries and differential response to levodopa based on dopamine levels predicting amelioration or overdosing.

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“…Also, areas of vision, speech, smell, learning, memory, and cognition were affected in males more than females, including areas in the occipital lobe, the bilateral occipital fusiform gyrus, the left occipital cortex, the left lateral occipital cortex, the bilateral hippocampus, the bilateral amygdala, the bilateral fusiform cortex, the bilateral middle temporal gyrus, the bilateral planum polare, the right lingual gyrus, the bilateral insular cortex, the bilateral superior temporal gyrus, the bilateral heschl's gyrus, the left cudate, the left thalamus, the bilateral occipital pole, the bilateral cingulate gyrus, the bilateral precuneus cortex, the left frontal pole, the right frontal medial cortex, the right subcallosal cortex, the bilateral frontal orbital cortex, the left superior frontal cortex, and the right paracingulate gyrus [78][79][80][81][82][83]. On the other hand, females presented more atrophy in the anterior division of the Para hippocampal gyrus, the brain stem, and the frontal orbital cortex, which involves visuospatial and subperceptual functions, motor skills, recognition of emotions, and decision making [84][85][86]. In addition, the results of the previous literature did not include any data on gender differences; however, the results of the VBM analysis of the previous study were consistent with the current study.…”

Section: Vbm Analysismentioning

confidence: 99%

Structural Brain Sex Differences in Parkinson’s Disease: A Voxel-Based Morphometry Study

Alqarni¹

2017

J Neurol Disord

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Brain structural MRI correlates of cognitive dysfunctions in Parkinson's disease

Cited by 82 publications

References 41 publications

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

Paradoxical Effect of Dopamine Medication on Cognition in Parkinson’s Disease: Relationship to Side of Motor Onset

Structural Brain Sex Differences in Parkinson’s Disease: A Voxel-Based Morphometry Study

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