Brain Structural Change and Gait Decline: A Longitudinal Population‐Based Study

Callisaya, Michele L.; Beare, Richard; Phan, Thanh G.; Blizzard, Leigh; Thrift, Amanda G.; Chen, Jian; Srikanth, Velandai

doi:10.1111/jgs.12331

Cited by 138 publications

(146 citation statements)

References 40 publications

(80 reference statements)

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“…The underlying mechanisms for our findings may include neurodegeneration (Rosano et al 2007;Callisaya et al 2013;Del Campo et al 2016) and vascular pathology (Callisaya et al 2013). Both cognition and gait impairments are associated with lower grey (Rosano et al 2007;Jokinen et al 2012;Callisaya et al 2014) and white matter volume (Callisaya et al 2013), as well as cerebrovascular disease such as white matter hyperintensities (Jokinen et al 2012) and cortical and subcortical infarcts (Rosano et al 2006;Choi.…”

Section: Discussionmentioning

confidence: 89%

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Cognitive status, fast walking speed and walking speed reserve—the Gait and Alzheimer Interactions Tracking (GAIT) study

et al. 2017

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The aims of this study were to (1) determine if older people at their fast walking speed (FWS) are able to reach the speed required at pedestrian crossings (>1.2 m/s) and (2) determine the role of cognitive impairment on the ability to alter speed and walk quickly. Participants were recruited from the Angers Memory Clinic, France. Gait speed was assessed at preferred and FWS using a GAITRite walkway. Walking speed reserve (WSR) was calculated as the difference between FWS and preferred speeds. Participants were classified into cognitive stages (cognitively healthy, mild cognitive impairment, mild and moderate dementia) based on neuropsychological evaluations. The proportion of participants with a FWS of <1.2 m/s was reported. The association between cognitive stage and preferred, fast and walking speed reserve was assessed using multivariable regression, adjusting for covariates. The mean age of the sample (n = 681) was 73.3 (SD 5.8) years. At preferred speed 73.7%, and at FWS 12.8%, of participants had speeds less than 1.2 m/s. Poorer cognitive stage was associated with slower preferred speed (β −0.08, 95% CI −0.10, −0.06), FWS (β −0.13, 95% CI −0.16, −0.10) and also with smaller WSR (m/s) (β −0.05, 95% CI −0.07, −0.03), but not WSR (%) (β −1.73, 95% CI −4.38, 0.93). In older people, worse stages of cognitive impairment were associated with poorer ability to increase speed and walk quickly. Such limitations may result in reduced ability to access the community.

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Section: Discussionmentioning

confidence: 89%

“…Both cognition and gait impairments are associated with lower grey (Rosano et al 2007;Jokinen et al 2012;Callisaya et al 2014) and white matter volume (Callisaya et al 2013), as well as cerebrovascular disease such as white matter hyperintensities (Jokinen et al 2012) and cortical and subcortical infarcts (Rosano et al 2006;Choi. 2012).…”

Section: Discussionmentioning

confidence: 99%

Cognitive status, fast walking speed and walking speed reserve—the Gait and Alzheimer Interactions Tracking (GAIT) study

et al. 2017

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“…These declines in fine motor control, gait, and balance increased variability of movement [9] and also slower movement [10] in comparison with young adults. Study by Callisaya ML et al in 2013 showed White matter atrophy was associated with a decline in gait speed, step length, and cadence. Hippocampal atrophy was associated with a decline in gait speed and step length, and total gray matter atrophy was associated with decline in cadence [11].…”

Section: Introductionmentioning

confidence: 97%

The effect of aging on gait parameters in able-bodied older subjects: a literature review

et al. 2015

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“…81,131 These techniques may have value in longitudinal studies of disease progression or treatment effects. 133 Although perfusion imaging does not yet play a role in the routine evaluation of FD, it has some useful research benefits. Compared with the contrast-based MR and CT methods, arterial spin labeling perfusion has the advantage of using magnetically labeled tagged spins and does not require the use of an exogenous contrast agent.…”

Section: Neuroimaging Techniques In Patients With Fdmentioning

confidence: 99%