Brain Scan Findings in Central Nervous System Involvement by Lupus Erythematosus

Bennahum, David A.; Messner, Ronald P.; Shoop, Jon D.

doi:10.7326/0003-4819-81-6-763

Cited by 39 publications

(13 citation statements)

References 5 publications

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“…Brain scans were equally unhelpful in our experience, being positive in only 19 % of cases and usually where gross pathology could be anticipated. This is in direct contrast to the view of Bennahum, Messner, and Shoop (1974), who suggested that it was a sensitive tool in the detection of cerebral lupus. The misinterpretation of abnormal scans due to focal infection in SLE has been recently emphasized (Stewart and Basten, 1975) and is an obvious hazard of this technique.…”

Section: Pathologycontrasting

confidence: 74%

Nervous system involvement in systemic lupus erythematosus

Gibson

Myers

1976

Annals of the Rheumatic Diseases

189

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. (1976). Annals of the Rheumatic Diseases, 35,[398][399][400][401][402][403][404][405][406]. Nervous system involvement in systemic lupus erythematosus. In a retrospective analysis of 80 patients with systemic lupus erythematosus (SLE) seen over a 10-year period, 41 (51 %) exhibited neurological manifestations. Nervous system involvement was characterized by a significantly greater involvement of black patients (P < 0 02), a higher incidence of renal failure after the first appearance of neurological features (P < 0 05), and a significantly worse 10-year survival rate (P < 0.05). Specific neurological investigations were generally unhelpful in diagnosis. (Trimble and others, 1974), were reviewed in detail. All clinical, laboratory, and treatment details were plotted sequentially for each patient. Convulsive or psychotic episodes occurring for the first time in association with uncontrolled hypertension (diastolic blood pressure > 120 mmHg) or severe uraemia (blood urea > 16-6 mmol/1; 100 mg/ml) were not considered primary manifestations of SLE and were excluded for the purpose of the study.

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Section: Pathologycontrasting

confidence: 74%

Nervous system involvement in systemic lupus erythematosus

Gibson

Myers

1976

Annals of the Rheumatic Diseases

189

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“…This is in agreement with Bennahum et al (1974) who reported abnormal brain scans in 11/12 scans in 6 patients with active CNS lupus. It is, however, in marked contrast to other published reports.…”

Section: Response To Therapysupporting

confidence: 93%

“…Recent evidence seems to indicate that the radionuclide brain scan can be useful in the diagnosis of CNS involvement in SLE (Bennahum et al, 1974). The present study reports our experience with radionuclide brain scan in SLE.…”

mentioning

confidence: 82%

Brain scan diagnosis of central nervous system involvement in systemic lupus erythematosus.

Tan¹,

Gladman²,

Urowitz³

et al. 1978

Annals of the Rheumatic Diseases

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suMMARY Twenty-five patients with 29 episodes of active systemic lupus erythematosus with central nervous system involvement were studied according to a uniform protocol. Brain scans were found to be abnormal in all patients studied, and electroencephalograms were abnormal in 20/25 patients. Serial brain scanning was found to be useful in the diagnosis of exacerbations and the monitoring of corticosteroid dosage.In a recent study of 110 patients with systemic lupus erythematosus (SLE), we found major neuropsychiatric manifestations in 44 patients (40%) including severe psychiatic disturbances or localised neurological lesions (Lee et al., 1977). The reported frequency of such manifestations in SLE ranges from 14-75% (Bennahum and Messner, 1975;Feinglass et al., 1976), the incidence varying with the criteria used for inclusion.In many instances, minor neuropsychiatric disturbances or severe headaches without localising signs are excluded because of poor neuropsychiatric and neuropathological correlations (Johnson and Richardson, 1968); yet these might represent active SLE with central nervous system (CNS) involvement. Available diagnostic procedures such as CSF examination or arteriography are frequently not helpful in diagnosing active CNS lupus.Recent evidence seems to indicate that the radionuclide brain scan can be useful in the diagnosis of CNS involvement in SLE (Bennahum et al., 1974). The present study reports our experience with radionuclide brain scan in SLE. Material and methods PATIENTSTwenty-five patients with active CNS SLE were studied. There were 21 females and 4 males, with a mean age of 34 9 years (range 21-75 years with only 3 patients over the age of 50) and a mean duration of SLE of 4 7 years. These patients were studied

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“…Abnormal flow brain scans are obtained in about 50 per cent of LE patients with CNS involvement (Bennahum, Messner & Shoop, 1974;Small et al, 1977).…”

Section: Laboratory Investigationsmentioning

confidence: 99%

Spinal cord involvement in systemic lupus erythematosus

Hachen¹,

Chantraine

1979

Spinal Cord

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Abstract. A review is made of the literature on central nervous system involvement in systemic lupus erythematosus (CNS-SLE). Particular attention is focused on lupus myelopathy. Referring to two well-documented personal cases, the authors describe the characteristic multisystem involvement, protean clinical pattern, serum and cere brospinal fluid changes, histoimmunologic findings, response to corticosteroids and immunosuppressive agents and some prognostic features.

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Brain Scan Findings in Central Nervous System Involvement by Lupus Erythematosus

Cited by 39 publications

References 5 publications

Nervous system involvement in systemic lupus erythematosus

Nervous system involvement in systemic lupus erythematosus

Brain scan diagnosis of central nervous system involvement in systemic lupus erythematosus.

Spinal cord involvement in systemic lupus erythematosus

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