Brain regions essential for improved lexical access in an aged aphasic patient: a case report

Meinzer, Marcus; Flaisch, Tobias; Obleser, Jonas; Assadollahi, Ramin; Djundja, Daniela; Barthel, Gabriela; Rockstroh, Brigitte

doi:10.1186/1471-2377-6-28

Cited by 49 publications

(49 citation statements)

References 32 publications

(37 reference statements)

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“…In addition, some have reported increased LH compared to RH activation after therapy (Cornelissen et al, 2003;Meinzer et al, 2004;Meinzer et al, 2007); others have found increased RH activation after therapy (Meinzer et al, 2006;Peck et al, 2004); while still others have reported bilateral activation after therapy (Fridriksson et al, 2006;Léger et al, 2002;Meinzer et al, 2007). Patterns of activation have also been reported to be more similar to controls' after therapy in one study (Léger et al, 2002), but not similar to controls' in another (Fridriksson et al, 2007).…”

Section: Introductionmentioning

confidence: 83%

“…In a second study, Fridriksson et al (2007) found increased activity bilaterally in the precuneus in two nonfluent patients who responded well to a combined semantic-phonological approach to naming treatment. Meinzer and colleagues (Meinzer, Obleser, Flaisch, Eulitz, & Rockstroh, 2007;Meinzer et al, 2006;Meinzer et al, 2008) have conducted both fMRI and MEG studies to investigate neuroplastic changes on naming abilities after Constraint-Induced Aphasia Therapy (CIAT). Meinzer et al (2006) showed that correct word retrieval after treatment was associated with increased activation in the right inferior frontal gyrus (IFG) in one patient, but more bilaterally (in frontotemporal areas) in another patient (Meinzer et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Meinzer and colleagues (Meinzer, Obleser, Flaisch, Eulitz, & Rockstroh, 2007;Meinzer et al, 2006;Meinzer et al, 2008) have conducted both fMRI and MEG studies to investigate neuroplastic changes on naming abilities after Constraint-Induced Aphasia Therapy (CIAT). Meinzer et al (2006) showed that correct word retrieval after treatment was associated with increased activation in the right inferior frontal gyrus (IFG) in one patient, but more bilaterally (in frontotemporal areas) in another patient (Meinzer et al, 2007). In their most recent study Meinzer et al (2008) have used MEG in addition to fMRI to show that improved naming abilities in a group of eleven patients with chronic aphasia were correlated with increased activation within LH perilesional areas.…”

Section: Introductionmentioning

confidence: 99%

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Neural changes after phonological treatment for anomia: An fMRI study

et al. 2010

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Functional magnetic resonance imaging (fMRI) was used to investigate the neural processing characteristics associated with word retrieval abilities after a phonologically-based treatment for anomia in two stroke patients with aphasia. Neural activity associated with a phonological and a semantic task was compared before and after treatment with fMRI. In addition to the two patients who received treatment, two patients with aphasia who did not receive treatment and 10 healthy controls were also scanned twice. In the two patients who received treatment, both of whose naming improved after treatment, results showed that activation patterns changed after treatment on the semantic task in areas that would have been expected (e.g., left hemisphere frontal and temporal areas). For one control patient, there were no significant changes in brain activation at the second scan; a second control patient showed changes in brain activation at the second scan, on the semantic task, however, these changes were not accompanied with improved performance in naming. In addition, there appeared to be bilateral, or even more right than left hemisphere brain areas activated in this patient than in the treated patients. The healthy control group showed no changes in activation at the second scan. These findings are discussed with reference to the literature on the neural underpinnings of recovery after treatment for anomia in aphasia.

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Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neural changes after phonological treatment for anomia: An fMRI study

et al. 2010

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“…35 In addition, Crosson et al 35 raised the possibility that under some circumstances, activation of either the right or left hemisphere may actually interfere with rather than promote recovery of language function. Only a few studies using fMRI to monitor aphasia therapy have been published to date (eg, Wierenga et al, 39 Crosson et al, 40 Meinzer et al, 41 Peck et al, 42 Fridriksson et al, 43 and Vitali et al, 38 ), but unfortunately these studies included only small sample sizes and demonstrated divergent results regarding predominance of left-versus-right hemispheric recruitment as manifestation of posttreatment language plasticity.…”

Section: 22mentioning

confidence: 99%

Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level–Dependent Functional MR Imaging

Pillai

2009

AJNR Am J Neuroradiol

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SUMMARY: BOLD fMRI has provided new insights into postlesional brain language plasticity by providing a noninvasive in vivo approach to evaluate longitudinal changes in brain cortical activation during performance of language tasks. Specifically, BOLD fMRI has provided the opportunity to investigate not only changes in eloquent language cortex resulting from different types of brain pathology such as brain tumors, stroke, and epilepsy but also changes in eloquent language cortex occurring as a result of actual surgical resection of diseased but, nevertheless, partially functional tissue. In addition to reviewing the literature relating to stroke and epilepsy-related language plasticity as well as the more intriguing phenomenon of postsurgical plasticity in the setting of brain tumors, 2 unusual cases illustrating this latter manifestation of language plasticity are briefly described in this review article.ABBREVIATIONS: BOLD ϭ blood oxygen levelϪdependent; DECS ϭ direct electrical cortical stimulation (intraoperative mapping); fMRI ϭ functional MR imaging; GABA ϭ gamma-aminobutyric acid (neurotransmitter); L ϭ left; LI ϭ laterality index; LIFG ϭ left inferior frontal gyrus; MPRAGE ϭ magnetization-prepared rapid acquisition gradient echo; NV ϭ noun-verb (association); P ϭ phonological (rhyming); PET ϭ positron-emission tomography; R ϭ right; RIFG ϭ right inferior frontal gyrus; S1 ϭ first (preoperative) fMRI scanning session; S2 ϭ second (first postoperative) fMRI scanning session; S3 ϭ third (second postoperative) fMRI scanning session; SPM ϭ Statistical Parametric Mapping; TLE ϭ temporal lobe epilepsy B

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“…Thus, in the last decade, the conceptualization of constraint has changed considerably, from one that was interpreted as focused solely on a response modality to one that focuses on the manner in which language action games, stimulus materials, explicit turn-taking rules, and behavioral techniques such as modeling, shaping, and positive reinforcement support overcoming learned nonuse. During this time, a growing number of investigators has replicated positive language outcomes first described by Pulvermüller et al (2001), following as little as 2 weeks of intensive therapy incorporating these three basic principles (Breier, Maher, Novak, & Papanicolaou, 2006;Kurland, Baldwin, & Tauer, 2010;Kurland, Pulvermüller, Silva, Burke, & Andrianopoulos, 2012;Maher et al, 2006;Meinzer et al, 2006Meinzer et al, , 2008.…”

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confidence: 99%

Intensive Language Action Therapy in Chronic Aphasia: A Randomized Clinical Trial Examining Guidance by Constraint

Kurland

Stanek

Stokes

et al. 2016

Am J Speech Lang Pathol

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Purpose Intensive language action therapy (ILAT) can be effective in overcoming learned nonuse in chronic aphasia. It is suggested that all three guiding principles (constraint, communication embedding, massed practice) are essential to ILAT's success. We examined whether one of these, guidance by constraint, is critical. Method Twenty-four participants with aphasia (PWAs) were assigned to ILAT or a modified version of promoting aphasic communicative effectiveness (PACE) in a randomized block, single-blind, parallel-group treatment study. Blocking was by severity (mild/moderate, moderate to severe, severe). Both groups received intensive treatment in the context of therapeutic language action games. Whereas the ILAT group was guided toward spoken responses, the PACE group could choose any response modality. Results All participants, whether assigned to ILAT or PACE groups, improved on the primary outcome measure, picture naming. There was a Severity × Treatment interaction, with the largest effects estimated for PWAs with mild/moderate and moderate to severe aphasia. Regardless of severity, the ILAT group outperformed the PACE group on untrained pictures, suggesting some benefit of ILAT to generalization. However, this difference was not statistically significant. Conclusion Although the groups differed in subtle ways, including better generalization to untrained pictures for ILAT, the study was inconclusive on the influence of guidance by constraint.

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Brain regions essential for improved lexical access in an aged aphasic patient: a case report

Cited by 49 publications

References 32 publications

Neural changes after phonological treatment for anomia: An fMRI study

Neural changes after phonological treatment for anomia: An fMRI study

Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level–Dependent Functional MR Imaging

Intensive Language Action Therapy in Chronic Aphasia: A Randomized Clinical Trial Examining Guidance by Constraint

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