Neural changes after phonological treatment for anomia: An fMRI study

Rochon, Elizabeth; Léonard, Carol; Burianová, Hana; Laird, Laura; Sörös, Peter; Graham, Simon J.; Grady, Cheryl L.

doi:10.1016/j.bandl.2010.05.005

Cited by 53 publications

(52 citation statements)

References 62 publications

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“…Our results support the role of left IFG activation in acute poststroke patients submitted to language rehabilitation and The activation of left IFG has also been described as a reflection of a therapy-induced improvement of naming 8,12 in chronic aphasics, whereas right IFG has been described to be activated both by healthy subjects who were taught to name objects in a foreign language 40 and in aphasics with left IFG lesions. 41 Our study suggests a possible dichotomy between LH and RH IFG activation, respectively, in early rehabilitated and spontaneously recovered aphasics.…”

Section: Strokesupporting

confidence: 71%

“…Neural correlates of the training-induced neuropsychological improvement have been reported to be different in relation to the linguistic task used, 42,43 as well as in relation to the training used both in aphasia 12 and in other nonstroke-induced neuropsychological symptoms, that is, the executive functions and information processing training in multiple sclerosis. 44 This pilot study, however, has several limitations.…”

Section: Strokementioning

confidence: 99%

“…Most studies focused on the spontaneous recovery of language, [1][2][3][4][5][6][7] but only a few, often single case descriptions, focused on patients submitted to language rehabilitation. [8][9][10][11][12][13] All of these were conducted on chronic patients. The rate of complete spontaneous (ie, without language therapy) aphasia recovery poststroke has been estimated at ≈33% in the first month, 43% after 4 months, and 50% 12 months later.…”

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confidence: 99%

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Early Aphasia Rehabilitation Is Associated With Functional Reactivation of the Left Inferior Frontal Gyrus

Mattioli

Ambrosi

Mascaro

et al. 2014

Stroke

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A n important issue for language rehabilitation after stroke is the relationship between the effects of therapeutic interventions and the functional changes observed in brain language-related areas. Most studies focused on the spontaneous recovery of language, [1][2][3][4][5][6][7] but only a few, often single case descriptions, focused on patients submitted to language rehabilitation. [8][9][10][11][12][13] All of these were conducted on chronic patients. The rate of complete spontaneous (ie, without language therapy) aphasia recovery poststroke has been estimated at ≈33% in the first month, 43% after 4 months, and 50% 12 months later.14 However, the concept of spontaneous recovery of language may not be appropriate (as human beings are extensively exposed to language). The term language therapy commonly relates to formal interventions provided by speech therapists aimed at improving different language abilities with specific exercises.Evidence supports the use of language rehabilitation in stroke, particularly if intensively administered for short courses in chronic aphasics. 15,16 In a pilot study, Godecke et al 17 found that daily aphasia therapy in early stroke, that is, mean 3 days poststroke (dps), resulted in improved communication outcomes in moderate to severe aphasia. Brain plasticity induced by language training has not been extensively investigated to date. Several studies, conducted in chronic patients, suggested that functional correlates of aphasia recovery could be either the activation of predominantly left hemisphere (LH) language-related areas [18][19][20][21][22] or of the homologous right hemisphere (RH) areas, 2,23-25 but often the authors do not clarify whether patients were formally treated and to what extent, or not. Saur et al 4 suggest that in the postacute stages of recovery (2 weeks poststroke), the LH areas would be reduced in activation, whereas after months Background and Purpose-Early poststroke aphasia rehabilitation effects and their functional MRI (fMRI) correlates were investigated in a pilot, controlled longitudinal study. Methods-Twelve patients with mild/moderate aphasia (8 Broca, 3 anomic, and 1 Wernicke) were randomly assigned to daily language rehabilitation for 2 weeks (starting 2.2 [mean] days poststroke) or no rehabilitation. The Aachen Aphasia Test and fMRI recorded during an auditory comprehension task were performed at 3 time intervals: mean 2.2 (T1), 16.2 (T2), and 190 (T3) days poststroke. Results-Groups did not differ in terms of age, education, aphasia severity, lesions volume, baseline fMRI activations, and in task performance during fMRI across examinations. Rehabilitated patients significantly improved in naming and written language tasks (P<0.05) compared with no rehabilitation group both at T2 and T3. Functional activity at T1 was reduced in language-related cortical areas (right and left inferior frontal gyrus and middle temporal gyrus, right inferior parietal lobule and superior temporal gyrus) in patients compared with controls. T2 and T3 follow-ups r...

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Section: Strokesupporting

confidence: 71%

Section: Strokementioning

confidence: 99%

mentioning

confidence: 99%

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Early Aphasia Rehabilitation Is Associated With Functional Reactivation of the Left Inferior Frontal Gyrus

Mattioli

Ambrosi

Mascaro

et al. 2014

Stroke

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“…In addition, data addressing the neural changes that occur as a function of the therapy are presented, following upon our previous work addressing this topic (Rochon et al, 2010). The element of choice (or active engagement on the part of a participant in his/her therapy) has been raised as a potential factor that leads to better treatment effects.…”

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confidence: 99%

Behavioural and neural changes after a “choice” therapy for naming deficits in aphasia: preliminary findings

et al. 2014

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Abstract:Background: Anomia, difficulty producing words, is a pervasive symptom of many individuals with aphasia. We have developed a treatment for naming deficits -the Phonological Components Analysis (PCA) protocol -that has proven efficacious for individuals with poststroke aphasia.Aims: The aim of the present investigation is to present preliminary findings exploring the potential influence of choice on our PCA treatment. Conclusion:The efficacy of PCA treatment for naming deficits is further supported. Also, continued exploration of task factors that may promote even better treatment effects using this protocol is warranted, as is continued investigation of the neural underpinnings associated with treatment effects.

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“…A successful language recovery may follow a systematic time course so that residual perilesional activity occurs in early post-stroke aphasia, followed by recruitment of right homologues in the subacute phase (Rochon et al, 2010;Saur et al, 2006) or as necessary (Crosson et al, 2007), and a subsequent return to the upregulation of perilesional regions in the left hemisphere in the chronic phase (Saur et al, 2006;van Oers et al, 2010). However, recovery is highly variable and there is clearly a need for more longitudinal fMRI studies which examine how brain structure and function is reorganised over the course of aphasia recovery and contributes to improved language function.…”

Section: Stages Of Recoverymentioning

confidence: 99%

Neurophysiological Markers of Language Recovery in Subacute Stroke

Roxbury¹

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Most patients with aphasia recover language function to some degree, but there is significant variability in the speed, nature, and extent of language recovery that occurs in the months following a stroke. Currently, there is no effective method available to predict how an individual with aphasia will recover. The most accurate predictors of recovery to date rely on global outcome measures which do not provide relevant information regarding recovery of symptoms that are targeted in therapy. The overall goal of this thesis was to examine whether language-related brain activity predicted recovery of specific symptoms in aphasia. The first aim was to gain a clearer understanding of the neural mechanisms which underpin word processing in healthy individuals.Brain activity associated with spoken word processing was investigated firstly in a group of healthy young adults, then in a healthy older cohort in order to ascertain whether task performance was preserved in ageing and if so, whether a preserved performance was underpinned by age-related changes in the neural mechanisms. The second main aim was to investigate the neural substrates which underpin language processing in the subacute (2-6 weeks) and chronic (6 months) phases of aphasia recovery and to determine whether the timing and extent to which these mechanisms are recruited contributes to a good or poor language outcome. An auditory lexical decision task with a novel pseudoword condition was employed to investigate language recovery mechanisms and was selected to ensure that patients with aphasia in the subacute stage would be able to perform the task with sufficient accuracy. The real word stimuli consisted of concrete and abstract items. The stimuli were presented in an event-related fMRI task to young healthy controls, older healthy controls, and patients with aphasia during the subacute and chronic phases post-stroke. A range of behavioural language measures was administered to all three cohorts and at both time points for patients with aphasia.In the healthy young group, concrete words elicited increased activity in a widely distributed network of brain regions including bilateral angular gyrus (AG), left posterior cingulate and left dorsolateral prefrontal cortex, compared to abstract words. Meanwhile, no region showed increased activity for abstract compared to concrete words, rather differences were only observed in bilateral AG when abstract words were contrasted with pseudowords. In the healthy older group, region of interest (ROI) results identified that a preserved performance was associated with an altered pattern of left hemisphere activity in the inferior and middle frontal regions, the AG and the fusiform gyrus.Differences between the healthy older and healthy young group were identified in key language regions, with the left inferior frontal gyrus (IFG) showing increased activity for abstract and pseudowords compared to concrete words while increased activity in the left AG was observed in the younger group only.ii In patients with a...

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Neural changes after phonological treatment for anomia: An fMRI study

Cited by 53 publications

References 62 publications

Early Aphasia Rehabilitation Is Associated With Functional Reactivation of the Left Inferior Frontal Gyrus

Early Aphasia Rehabilitation Is Associated With Functional Reactivation of the Left Inferior Frontal Gyrus

Behavioural and neural changes after a “choice” therapy for naming deficits in aphasia: preliminary findings

Neurophysiological Markers of Language Recovery in Subacute Stroke

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