Brain Phosphatidylserine: Metabolism and Functions

Mozzi, Rita; Buratta, Sandra

doi:10.1007/978-0-387-30378-9_3

Cited by 7 publications

(7 citation statements)

References 157 publications

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“…PS34:1, PS38:5, PS40:6 and PS40:5 were also significantly decreased in both left and right sides of the prefrontal cortex indicating the stimulation of enzymes associated with degradation of PS. It is possible that the decrease in PSs is due to decarboxylation to form PEs (Vance 2008;Mozzi and Buratta 2010).…”

Section: Discussionmentioning

confidence: 98%

Brain lipid changes after repetitive transcranial magnetic stimulation: potential links to therapeutic effects?

Lee

Tan

et al. 2011

Metabolomics

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Repetitive transcranial magnetic stimulation (rTMS) is increasingly used in the management of neurologic disorders such as depression and chronic pain, but little is known about how it could affect brain lipids, which play important roles in membrane structure and cellular functions. The present study was carried out to examine the effects of rTMS on brain lipids at the individual molecular species level using the novel technique of lipidomics. Rats were subjected to high frequency (15 Hz) stimulation of the left hemisphere with different intensities and pulses of rTMS. The prefrontal cortex, hippocampus and striatum were harvested 1 week after rTMS and lipid profiles analyzed by tandem mass spectrometry. rTMS resulted in changes mainly in the prefrontal cortex. There were significant alterations in plasmalogen phosphatidylethanolamines, phosphatidylcholines, and increases in sulfated galactosylceramides or sulfatides. Plasmalogen species with long chain polyunsaturated fatty acids (PUFAs) showed decrease in abundance together with corresponding increase in lysophospholipid species suggesting endogenous release of long chain fatty acids such as docosahexaenoic acid (DHA) in brain tissue. The hippocampus showed no significant changes, whilst changes in the striatum were often opposite to that of the prefrontal cortex. It is postulated that changes in brain lipids may underlie some of the clinical effects of rTMS.

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Section: Discussionmentioning

confidence: 98%

Brain lipid changes after repetitive transcranial magnetic stimulation: potential links to therapeutic effects?

Lee

Tan

et al. 2011

Metabolomics

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“…In addition to their essential roles in cell membrane structural integrity, PLs play critical roles in lung and brain development in the growing infant [19,20,21,22,23]. The PLs in HM are mainly found in the tri-layer of the MFGM and consist of sphingomyelins (SMs) and the glycerophospholipids phosphatidyl choline (PC) and its lyso species (L-PC), phosphatidyl ethanolamine (PE) and its lyso species (L-PE), phosphatidyl inositol (PI), and phosphatidyl serine (PS).…”

Section: Introductionmentioning

confidence: 99%

Human Milk Oligosaccharide, Phospholipid, and Ganglioside Concentrations in Breast Milk from United Arab Emirates Mothers: Results from the MISC Cohort

McJarrow

Radwan

et al. 2019

Nutrients

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Human milk oligosaccharides (HMOs), phospholipids (PLs), and gangliosides (GAs) are components of human breast milk that play important roles in the development of the rapidly growing infant. The differences in these components in human milk from the United Arab Emirates (UAE) were studied in a cross-sectional trial. High-performance liquid chromatography‒mass spectrometry was used to determine HMO, PL, and GA concentrations in transitional (5–15 days) and mature (at 6 months post-partum) breast milk of mothers of the United Arab Emirates (UAE). The results showed that the average HMO (12 species), PL (7 species), and GA (2 species) concentrations quantified in the UAE mothers’ transitional milk samples were (in mg/L) 8204 ± 2389, 269 ± 89, and 21.18 ± 11.46, respectively, while in mature milk, the respective concentrations were (in mg/L) 3905 ± 1466, 220 ± 85, and 20.18 ± 9.75. The individual HMO concentrations measured in this study were all significantly higher in transitional milk than in mature milk, except for 3 fucosyllactose, which was higher in mature milk. In this study, secretor and non-secretor phenotype mothers showed no significant difference in the total HMO concentration. For the PL and GA components, changes in the individual PL and GA species distribution was observed between transitional milk and mature milk. However, the changes were within the ranges found in human milk from other regions.

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“…Although controversy exists regarding ASIC1a subcellular distributions in neurons ( 19, 41 ), our data clearly show that ASIC1a and Lact-C2 are enriched and well-colocalized at peri-synaptic sites in spine heads, and the expression of ASIC1a and PS there positively correlates with the sizes of the spine heads and PSD. Since both PS ( 42, 43 ) and ASIC1a ( 44, 45 ) exist in high levels and undergo regulated processing in neurons, our data also indicate that ASIC1a and PS may play important roles in spine morphology and synaptic function.…”

Section: Resultsmentioning

confidence: 54%

Phosphatidylserine controls synaptic targeting and membrane stability of ASIC1a

Liu

Song

Liu

et al. 2022

Preprint

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Phospholipid-protein interaction is highly specialized at the membranous nanodomains and critical for membrane receptor signaling. Calcium-permeable acid-sensing ion channel isoform 1a (ASIC1a) is a major neuronal proton sensor that contributes to synaptic plasticity. The functional outcome of ASIC1a is dependent on its surface targeting in synaptic subdomains; however, the lipid environment for ASIC1a and its role in channel targeting remain poorly understood. Here, we report that anionic phosphatidylserine (PS) is enriched in dendritic spines during neurodevelopment and it directly binds to ASIC1a through an electrostatic interaction with a di-arginine motif at ASIC1a C-terminus. PS regulates the membrane targeting and function of ASIC1a, which are both strongly suppressed by inhibition of PS synthesis. In cortical neuron dendrites, both PS and ASIC1a are predominately localized to peri-synaptic sites of spine heads, surrounding instead of overlapping with postsynaptic markers, PSD-95 and GluN1. Uncoupling the interaction between PS and ASIC1a by changing the charges to neutral or acidic at the di-arginine PS-binding motif, or applying a membrane penetrating competing peptide, caused mistargeting of ASIC1a at the synaptic sites, an overall increase in internalization and/or cytoplasmic accumulation of ASIC1a, and a decrease in its channel function. Together, our results provide novel insights on lipid microenvironment that governs ASIC1a expression and function at the membrane surface, especially peri-synaptic regions of dendritic spines, through an electrostatic interaction with anionic phospholipids.

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Brain Phosphatidylserine: Metabolism and Functions

Cited by 7 publications

References 157 publications

Brain lipid changes after repetitive transcranial magnetic stimulation: potential links to therapeutic effects?

Brain lipid changes after repetitive transcranial magnetic stimulation: potential links to therapeutic effects?

Human Milk Oligosaccharide, Phospholipid, and Ganglioside Concentrations in Breast Milk from United Arab Emirates Mothers: Results from the MISC Cohort

Phosphatidylserine controls synaptic targeting and membrane stability of ASIC1a

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