Brain natriuretic peptide levels predict successful cardioversion and rhythm maintenance in patients with chronic atrial fibrillation

Beck-da-Silva, Luís; Bold, Adolfo J. de; Fraser, Margaret; Williams, Kathryn; Struthers, Christine; Abaiian, K.; Haddad, Haissam

doi:10.1016/s0735-1097(03)80981-6

Cited by 30 publications

(38 citation statements)

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“…BNP is rarely stored in a healthy heart, and its highly productive synthesis is achieved under stimulation. BNP secretion is closely correlated with the volume and pressure load of heart chambers (Beck-da-Silva et al, 2004;Date et al, 2006;Wozakowska-Kaplon and Opolski, 2010;Tang et al, 2011;Barassi et al, 2012;Govindan et al, 2012). In the successful ablation group, BNP levels significantly decreased 2 h after surgery (P < 0.01) and declined even further after three months (P < 0.01), which is consistent with the results in the literature (Marsiliani et al, 2010;Deftereos et al, 2011;Freynhofer et al, 2011;Higa et al, 2011;Kawabata et al, 2011;Ruggiero et al, 2011;Psychari et al, 2011).…”

Section: Discussionsupporting

confidence: 83%

Clinical significance and levels of blood brain natriuretic peptides in patients with persistent atrial fibrillation before and after catheter ablation

Sy¹,

Hl²,

Ps³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to observe levels of blood brain natriuretic peptides (BNPs) in patients with persistent atrial fibrillation (AF) before and after catheter ablation. Thirty-six patients with persistent AF (28 successful surgeries and eight recurrent cases) and 36 healthy controls with normal sinus rhythm were recruited for this study. BNP levels in the AF and control groups were measured before and after catheter ablation. BNP levels before surgery were significantly higher in the persistent AF group than in the control group (P < 0.01). The successful surgery group had distinctly lower BNP levels before ablation than the recurrent group (P < 0.01). In the recurrent group, BNP levels 2 h after ablation were significantly lower than those before ablation (P < 0.01); these levels increased after AF recurrence (P < 0.01) and were comparable with those before ablation (P < 0.01). Logistic regression analysis indicated that the BNP level was an inde-S.Y. Xing et al. 6954©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6953-6959 (2015) pendent factor for and predictor of AF recurrence (P < 0.01). The BNP level in patients with persistent AF is clinically important in predicting and evaluating AF recurrence after ablation.

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Section: Discussionsupporting

confidence: 83%

Clinical significance and levels of blood brain natriuretic peptides in patients with persistent atrial fibrillation before and after catheter ablation

Sy¹,

Hl²,

Ps³

et al. 2015

Genet. Mol. Res.

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“…[13][14][15][16][17][18][19] Therefore, the aim of our study was: (1) to determine the predictive value of serial NT-proBNP measurements on the success of an elective direct-current cardioversion; and (2) to assess the ability to monitor rhythm stability after electrical cardioversion in patients with lone AF.…”

Section: Discussionmentioning

confidence: 99%

“…After enzymatic cleavage, it is released into the circulation system in equimolar proportions as the hormonally active BNP and the inactive amino-terminal fragment N-terminal (NT)-proBNP. Recent studies have shown, that BNP and NT-proBNP, respectively, are increased in patients with AF and rapidly fall upon restoration of SR. 13,14 Therefore, the purpose of the present study was to elucidate, whether NT-proBNP can: (1) predict the short-term outcome of an elective direct current cardioversion; and (2) be used to monitor rhythm stability. …”

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confidence: 99%

NT-ProBNP Predicts Rhythm Stability After Cardioversion of Lone Atrial Fibrillation

Möllmann

Weber

Elsässer

et al. 2008

Circ J

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trial fibrillation (AF) is the most common arrhythmia diagnosed in daily clinical practice. The prevalence in the general population is estimated to be 0.4% to 1%, and this increases with age to 8% in those older than 80 years. 1,2 The percentage of lone AF ranges from 12% to 30% of these patients. 2,3 It is likely, that the overall incidence of AF will rise further in the next few decades as the elderly population increases in size.AF is associated with an increased long-term risk of stroke, heart failure and all-cause mortality. 4,5 The rate of ischemic stroke among patients with non-valvular AF averages 5% per year, 2 to 7 times that of people without AF. 6 Oral anticoagulation with warfarin or other vitamin-Kantagonists reduces this risk related to AF by about 70%. 7,8 However, oral anticoagulants raise the risk of major bleeding from 0.9% to 2.2% and thus should be only used in a carefully selected cohort. 9 Therefore, in clinical practice, AF remains one of the most difficult arrhythmias to treat and the criteria for selecting different therapeutic options for patients is still a matter of debate. 10 Although several studies Circulation Journal Vol.72, June 2008 propose that a rate-controlling approach might be superior to the rhythm-controlling approach, clinical symptoms of AF such as palpitations, reduced exercise tolerance and impact on quality of life provide obvious reasons for considering early restoration and maintenance of sinus rhythm (SR). 11,12 B-type natriuretic peptide (BNP) is synthesized as preproBNP in response to ventricular stretch and pressure overload. After enzymatic cleavage, it is released into the circulation system in equimolar proportions as the hormonally active BNP and the inactive amino-terminal fragment N-terminal (NT)-proBNP. Recent studies have shown, that BNP and NT-proBNP, respectively, are increased in patients with AF and rapidly fall upon restoration of SR. 13,14 Therefore, the purpose of the present study was to elucidate, whether NT-proBNP can: (1) predict the short-term outcome of an elective direct current cardioversion; and (2) be used to monitor rhythm stability. Methods Study Population and ProtocolFifty-three consecutive patients who were referred to our institution for elective cardioversion of AF and who met the inclusion criteria were enrolled into the present study. Inclusion criteria were: (1) AF at the time of enrollment evidenced through 12-lead ECG; (2) eligibility of a directcurrent cardioversion documented using a sufficient oral anticoagulation over >4 weeks or absence of an atrial thrombus, evidenced by transoesophageal echocardiography; (3) absence of structural heart diseases, that is, known or susCirc J 2008; 72: 921 -925 (Received October 11, 2007; revised manuscript received December 27, 2007; accepted January 7, 2008) Kerckhoff-Klinik Bad Nauheim, Bad Nauheim, *Universitätsklinikum Frankfurt, Frankfurt, Germany **The first two authors contributed equally. Mailing address: Helge Möllmann, MD, Kerckhoff Heart Center, Benekestraße 2-8, 6123...

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“…Therefore, the elevated BNP levels in this study would have resulted from the presence of AF itself, but were not an indicator of the development of heart failure [1][2][3][4] or AF recurrence. 24,25) In fact, BNP levels have previously been shown to increase in the presence of AF despite the absence of heart failure. [5][6][7][8] Lee, et al 7) concluded that BNP levels were found to be significantly correlated with the left atrial volume index and tissue Doppler-derived E/E' (as an indicator of diastolic function) in patients with lone AF after adjusting for clinical and echocardiographic variables.…”

Section: Discussion Main Findingsmentioning

confidence: 99%

Electrophysiological Properties of the Atrium After Cardioversion of Chronic Atrial Fibrillation Relation to the Plasma Brain Natriuretic Peptide Level

et al. 2007

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Brain natriuretic peptide levels predict successful cardioversion and rhythm maintenance in patients with chronic atrial fibrillation

Cited by 30 publications

References 0 publications

Clinical significance and levels of blood brain natriuretic peptides in patients with persistent atrial fibrillation before and after catheter ablation

Clinical significance and levels of blood brain natriuretic peptides in patients with persistent atrial fibrillation before and after catheter ablation

NT-ProBNP Predicts Rhythm Stability After Cardioversion of Lone Atrial Fibrillation

Electrophysiological Properties of the Atrium After Cardioversion of Chronic Atrial Fibrillation Relation to the Plasma Brain Natriuretic Peptide Level

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