Electrophysiological Properties of the Atrium After Cardioversion of Chronic Atrial Fibrillation  Relation to the Plasma Brain Natriuretic Peptide Level

Okumura, Yasuo; Watanabe, Ichiro; Ashino, Sonoko; Kofune, Masayoshi; Takagi, Yasuhiro; Kofune, Tatsuya; Okubo, Kimie; Hashimoto, Kazuhito; Shindo, Atsushi; Sugimura, Hidezou; Nakai, Toshiko; Kasamaki, Yuji; Saito, Satoshi

doi:10.1536/ihj.48.485

Cited by 8 publications

(8 citation statements)

References 34 publications

(57 reference statements)

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“…Elevation of plasma NT-proBNP levels, despite the absence of obvious structural heart disease, was evident in patients with chronic AF, and no relationship was found between plasma NT-proBNP levels and intra-atrial conduction time (measured as the filtered Pdur) after cardioversion, in a previous study [27]. Evaluation of patients with persistent AF found that the baseline plasma BNP level and the magnitude of the decrease thereof after successful cardioversion, predicted AF recurrence [28].…”

Section: Relationships Of Pwd and Atrial Emd To Nt-probnp Levelsmentioning

confidence: 99%

Relationships between P wave dispersion, atrial electromechanical delay, left atrial remodeling, and NT-proBNP levels, in patients with hypertrophic cardiomyopathy

et al. 2015

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Background: We evaluated the associations among the well-known atrial fibrillation (AF) predictors including P-wave dispersion (PWD), intra-and inter-atrial electromechanical dyssynchrony (EMD), left atrial (LA) phasic functions, and plasma N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) levels, in patients with hypertrophic cardiomyopathy (HCM p = 0.001), p = 0.03), p = 0.006), but not, however, to LAAEFr (p = 0.4). The plasma NT-proBNP levels of patients were not correlated with either (Cardiol J 2015; 22, 1: 94-100)

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Section: Relationships Of Pwd and Atrial Emd To Nt-probnp Levelsmentioning

confidence: 99%

Relationships between P wave dispersion, atrial electromechanical delay, left atrial remodeling, and NT-proBNP levels, in patients with hypertrophic cardiomyopathy

et al. 2015

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“…1,2) It has been proven in previous studies that enhanced activity of matrix metalloproteinases (MMPs) may also be one of the mechanisms responsible for this. 3,4) It has been shown in animal studies that metalloproteinases in endocardial cells could be activated by homocysteine (Hcy).…”

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confidence: 99%

High Homocysteine Levels Predict the Recurrence of Atrial Fibrillation After Successful Electrical Cardioversion

et al. 2010

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SummaryRecent data suggest that elevated plasma levels of homocysteine could be associated with atrial fibrillation (AF). The aim of our study was to investigate whether elevated plasma Hcy levels were predictive of the recurrence rate of AF after successful electrical cardioversion.Eighty-three patients (63 ± 12 years, 61.4% men) with persistent AF lasting at least 7 days were included after successful electrical cardioversion. Echocardiography and plasma homocysteine assay were performed prior to cardioversion and patient baseline characteristics were obtained. Patients were monitored for a period of 18 months.The patients were divided into two groups using a cut-off value for the last quartile of plasma homocysteine concentration (> 14.4 μmol/L). Kaplan Meier analysis showed a statistically significant difference in AF recurrence rates between both groups after 18 months (P = 0.02, log rank test). Cox proportional hazards multivariate analysis showed that predictors of AF recurrence were the duration of AF (OR 1.05, 95% CI 1.02-1.08, P = 0.00), treatment with amiodarone (OR 0.39, 95% CI 0.21-0.72, P = 0.00), and homocysteine level ≤ 14.4 μmol/L (OR 0.39, 95% CI 0.21-0.73, P = 0.00).We found that the homocysteine levels determined prior to electrical cardioversion can predict recurrence of AF after successful restoration of sinus rhythm. (Int Heart J 2010; 51: 30-33)

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“…The precise mechanism explaining this BNP elevation has not been elucidated, but we showed previously that the BNP level was significantly higher in patients with AF than in those without AF, despite similar LVEFs. 21) LV diastolic dysfunction seems to increase secretion of BNP from the atria. 22,23) In the present study, plasma ANP and BNP levels were higher in patients with LAAT than in those without LAAT.…”

Section: Discussionmentioning

confidence: 97%

Noninvasive Surrogate Markers to Predict Thrombogenesis in Patients with Nonvalvular Atrial Fibrillation

Takahashi

Watanabe

Okumura

et al. 2016

Nichidai Igaku Zasshi

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Background: Atrial fibrillation (AF) confers a substantial increase in the risk of stroke. While the CHADS 2 score is considered a reliable predictor of stroke/thromboembolism risk in patients with AF, thromboembolism can occur even in AF patients with a low CHADS 2 score (CHADS 2 score = 0 or 1). We retrospectively assessed the relationships between left atrial appendage thrombus (LAAT) and patient characteristics, echocardiographic variables, and surrogate blood markers in patients with unanticoagulated AF, in order to determine whether thrombogenesis can be predicted in this patient population.Methods: The study group was comprised of 31 patients with unanticoagulated persistent non-valvular AF (NVAF) who underwent transthoracic echocardiography (TTE) and transesophageal echocardiography. Patients were divided into those with and without LAAT, and study variables were compared between the 2 groups.Results: LAAT was found in 14 patients. AF duration, left atrial diameter, left ventricular ejection fraction, left atrial appendage flow, β-thromboglobulin, platelet factor 4, prothrombin time, activated prothrombin time, fibrinogen, D-dimer, and antithrombin III levels did not differ between patients with and without LAAT. However, ANP and BNP levels were significantly higher in patients with LAAT (ANP ≥79 pg/ml, P = 0.03, BNP ≥120 pg/ml: P = 0.03). Moreover, patients with BNP ≥120 pg/ml exhibited an increased risk for LAAT (P = 0.03, odds ratio: 6.19), and patients with ANP ≥70 pg/ml in addition to BNP ≥120 pg/ml exhibited a further augmented risk for LAAT (P = 0.055, odds ratio: 8.75).Conclusions: In patients with unanticoagulated NVAF, a BNP level ≥120 pg/ml or an ANP level ≥70 pg/ml and BNP level ≥120 pg/ml could prove useful in predicting LAAT.

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Electrophysiological Properties of the Atrium After Cardioversion of Chronic Atrial Fibrillation Relation to the Plasma Brain Natriuretic Peptide Level

Abstract: SUMMARYBackground: Brain natriuretic peptide (BNP) level has been shown to increase in

Cited by 8 publications

References 34 publications

Relationships between P wave dispersion, atrial electromechanical delay, left atrial remodeling, and NT-proBNP levels, in patients with hypertrophic cardiomyopathy

Relationships between P wave dispersion, atrial electromechanical delay, left atrial remodeling, and NT-proBNP levels, in patients with hypertrophic cardiomyopathy

High Homocysteine Levels Predict the Recurrence of Atrial Fibrillation After Successful Electrical Cardioversion

Noninvasive Surrogate Markers to Predict Thrombogenesis in Patients with Nonvalvular Atrial Fibrillation

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