Brain metastases of melanoma—mechanisms of attack on their defence system by engineered stem cells in the microenvironment

Abstract

This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers.

Cyclic patterns of incidence rate for skin malignant melanoma: association with heliogeophysical activity

“…Plausible biophysical pathways for these cyclic non-photic HGA influences in the later appearance of SMM may be direct, with a predominantly local receipt of the impact by UV irradiation, solar protons or heavy-charged particles (Cucinotta and Durante, 2006;Encinas et al, 2008) on the epidermal, adnexal and dermal cells or cutaneous nerve endings. The direct effect may be targeted, acting upon the melanocytes and interfering with their melanocytic defence system (MDS) (Dimitrov et al, 2007), or it may firstly be spread, initially intermediated by the surrounding microenvironment (e.g., bystander effect, skin neuroendocrine system (Slominski, 2005) signalling, and adjacent skin neuro-immunity impairment). Alternatively, or in parallel, these pathways may be also indirect, by impacts of solar coronal-related geomagnetic storms, gravitational field changes, low-frequency (LF) geophysical fluctuations or Schumann resonance signals (Cherry, 2002;Kamide, 2003; on the brain activity, neuroendocrine axis modulations and haemato-immunological variations (Kamide, 2005).…”