Brain Metastases from Endometrial Carcinoma: Report of Three Cases and Review of the Literature

S, Orrù; Lay, Giancarlo; Dessi, Marina; Murtas, Rita; Deidda, Maria Assunta; Amichetti, Maurizio

doi:10.1177/030089160709300122

Cited by 13 publications

(18 citation statements)

References 48 publications

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“…[46], 6 (75%) presented with an advanced-stage (Stage III or IV) disease and 5 (62.5%) with a poorly-differentiated (G3) tumor. All 3 patients with brain metastases from endometrial carcinoma documented by Orrù et al [50] had at the time of diagnosis of the primary disease a poorly-differentiated (G3) advanced-stage (Stage III) endometrial carcinoma. At the time of diagnosis of the primary endometrial carcinoma in 20 patients with brain metastases reported by Chura et al [51], 17 (85%) presented with an advanced-stage (Stage III or IV) disease, 11 (55%) with a poorly-differentiated (G3) tumor, and 8 (40%) with an unfavorable histologic type (carcinosarcoma, adenosquamous carcinoma, and serous carcinoma).…”

Section: Characteristics Of the Primary Endometrial Carcinomamentioning

confidence: 99%

“…Orrù et al [50] found that endometrial carcinoma was the source of brain metastases in 3 (0.9%) of 348 patients with brain metastases referred to the Businco Regional Oncological Hospital, Cagliari, Italy for palliative radiotherapy during 1999–2005. Le Chevalier et al [59] reviewed retrospectively 120 consecutive patients presenting to The Gustave-Roussy Institute, Villejuif, France during 1959–1979 with brain metastases as the first sign of their malignancy.…”

Section: Incidence Of Brain Metastases From Endometrial Carcinomamentioning

confidence: 99%

“…Of 35 papers on brain metastases from endometrial carcinoma published in the literature, 19 documented one patient each [16, 19, 21, 25–29, 32, 38, 40, 43–45, 48, 49, 52, 54, 55], seven: 2 patients each [33–35, 37, 39, 42, 47], two: 3 patients each [30, 50], one: 6 patients [53], one: 8 patients [46], two: 10 patients each [36, 41], two: 11 patients [24, 31], and one: 20 patients [51]. Age at diagnosis of brain metastases from endometrial carcinoma ranged from 40 to 83 years with a median of 60 years (Table 1).…”

Section: Introductionmentioning

confidence: 99%

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Brain Metastases from Endometrial Carcinoma

Piura

2012

ISRN Oncology

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This paper will focus on knowledge related to brain metastases from endometrial carcinoma. To date, 115 cases were documented in the literature with an incidence of 0.6% among endometrial carcinoma patients. The endometrial carcinoma was usually an advanced-stage and high-grade tumor. In most patients (~90%), brain metastasis was detected after diagnosis of endometrial carcinoma with a median interval from diagnosis of endometrial carcinoma to diagnosis of brain metastases of 17 months. Brain metastasis from endometrial carcinoma was either an isolated disease limited to the brain only (~50%) or part of a disseminated disease involving also other parts of the body (~50%). Most often, brain metastasis from endometrial carcinoma affected the cerebrum (~75%) and was solitary (~60%). The median survival after diagnosis of brain metastases from endometrial carcinoma was 5 months; however, a significantly better survival was achieved with multimodal therapy including surgical resection or stereotactic radiosurgery followed by whole brain radiotherapy (WBRT) and/or chemotherapy compared to WBRT alone. It is suggested that brain imaging studies should be considered in the routine follow up of patients with endometrial carcinoma and that the search for a primary source in females with brain metastases of unknown primary should include endometrial biopsy.

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Section: Characteristics Of the Primary Endometrial Carcinomamentioning

confidence: 99%

Section: Incidence Of Brain Metastases From Endometrial Carcinomamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Brain Metastases from Endometrial Carcinoma

Piura

2012

ISRN Oncology

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“…1,2,6,7 Chemotherapy, surgical resection, whole-brain radiotherapy (WBRT), stereotactic radiosurgery, or combinations of these therapeutic modalities are the options in case of a metastatic brain tumor. 2,8,9 Surgery is the mainstay of treatment in patients with brain involvement regardless of tumor origin, especially for a single lesion. 10 Whole-brain radiotherapy is the standard therapy for unresectable tumors or resection cavity.…”

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confidence: 99%

Is Neurosurgery With Adjuvant Radiotherapy an Effective Treatment Modality in Isolated Brain Involvement From Endometrial Cancer?: From Case Report to Analysis

Kimyon

Turan

Başaran³

et al. 2017

Int J Gynecol Cancer

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“…Endometrial adenocarcinoma is the most common gynecologic malignancy and has a low incidence of metastasis to the brain, ranging from 0.3% to 1.4% [15,16].…”

Section: Discussionmentioning

confidence: 99%

Brain Metastases in a Patient with Ovarian Cancer

Kabulo¹

2017

IJNPT

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Abstrat: Brain metastases are associated with a poor prognosis. Depending on the patient's age, functional status, extent of systemic disease, and number of metastases. We report a case of 22-year-old female who presented with 2 months history of headache and vomiting and 1 day history of not communicating, neck stiffness, and generalized body weakness. Patient has been unwell for 2 months after she had collapsed at school 2 months prior complaining of severe headache, she allegedly stroked one month prior with left sided weakness. No history of trauma and seizures but had history of falling and remaining unconscious for unspecified period of time. No history of chronic illness and no family history of malignancies. Brain CT scan and MRI documented multiple lobulated irregularly enhancing brain parenchymal mass lesions of variable sizes, patient was taken to theatre and burr hole for brain tumor biopsy was done and specimen taken for histology which confirmed metastatic carcinoma and the tumor immunoreacted negatively to TTF1 and positively to CK7. Treatment of brain metastasis has evolved over the years from WBRT only for most patients to multimodal therapy including surgical resection, if feasible, followed by Whole brain Radiotherapy (WBRT) and/or chemotherapy.

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Brain Metastases from Endometrial Carcinoma: Report of Three Cases and Review of the Literature

Abstract: The combination of surgery and postoperative whole-brain irradiation in selected patients with solitary brain metastases from endometrial carcinoma is an effective method of palliation.

Cited by 13 publications

References 48 publications

Brain Metastases from Endometrial Carcinoma

Brain Metastases from Endometrial Carcinoma

Is Neurosurgery With Adjuvant Radiotherapy an Effective Treatment Modality in Isolated Brain Involvement From Endometrial Cancer?: From Case Report to Analysis

Brain Metastases in a Patient with Ovarian Cancer

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