2007
DOI: 10.1177/030089160709300122 View full text |Buy / Rent full text
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Abstract: The combination of surgery and postoperative whole-brain irradiation in selected patients with solitary brain metastases from endometrial carcinoma is an effective method of palliation.

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“…[46], 6 (75%) presented with an advanced-stage (Stage III or IV) disease and 5 (62.5%) with a poorly-differentiated (G3) tumor. All 3 patients with brain metastases from endometrial carcinoma documented by Orrù et al [50] had at the time of diagnosis of the primary disease a poorly-differentiated (G3) advanced-stage (Stage III) endometrial carcinoma. At the time of diagnosis of the primary endometrial carcinoma in 20 patients with brain metastases reported by Chura et al [51], 17 (85%) presented with an advanced-stage (Stage III or IV) disease, 11 (55%) with a poorly-differentiated (G3) tumor, and 8 (40%) with an unfavorable histologic type (carcinosarcoma, adenosquamous carcinoma, and serous carcinoma).…”
Section: Characteristics Of the Primary Endometrial Carcinomamentioning
“…Orrù et al [50] found that endometrial carcinoma was the source of brain metastases in 3 (0.9%) of 348 patients with brain metastases referred to the Businco Regional Oncological Hospital, Cagliari, Italy for palliative radiotherapy during 1999–2005. Le Chevalier et al [59] reviewed retrospectively 120 consecutive patients presenting to The Gustave-Roussy Institute, Villejuif, France during 1959–1979 with brain metastases as the first sign of their malignancy.…”
Section: Incidence Of Brain Metastases From Endometrial Carcinomamentioning
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“…1,2,6,7 Chemotherapy, surgical resection, whole-brain radiotherapy (WBRT), stereotactic radiosurgery, or combinations of these therapeutic modalities are the options in case of a metastatic brain tumor. 2,8,9 Surgery is the mainstay of treatment in patients with brain involvement regardless of tumor origin, especially for a single lesion. 10 Whole-brain radiotherapy is the standard therapy for unresectable tumors or resection cavity.…”
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“…Endometrial adenocarcinoma is the most common gynecologic malignancy and has a low incidence of metastasis to the brain, ranging from 0.3% to 1.4% [15,16].…”
Section: Discussionmentioning