Brain Ischemia in Patients with Intracranial Hemorrhage: Pathophysiological Reasoning for Aggressive Diagnostic Management

Naranjo, Daniel; Arkuszewski, Michał; Rudziński, Wojciech; Melhem, Elias R.; Krejza, Jarosław

doi:10.1177/197140091302600603

Cited by 15 publications

(9 citation statements)

References 229 publications

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“…The formation of hematoma after the occurrence of acute cerebral hemorrhage can promote the release of a large amount of inflammatory factors and inflammatory mediators which participate in secondary brain injury that is the key factor influencing the prognosis of patients. 17 TNF-α, IL-8 and hs-CRP as the important regulatory factors in inflammatory reaction and immune response plays important roles in the occurrence of secondary brain injury induced by intracranial hemorrhage. 18 Therefore, levels of TNF-α, IL-8 and hs-CRP can reflect edema around intracranial hematoma of patients with intracranial hemorrhage, which is of great significance to studies on the treatment of acute cerebral hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

“…It severely affects the living quality of patients and also brings heavy burden to the society. 1 - 3 Currently, the main therapies for hypertensive cerebral hemorrhage include conservative treatment, surgery and minimally invasive hematoma evacuation; however, those therapies have certain limitations in practical application, especially in recovering neurological function. 4 , 5 The clinical efficacy of neuroprotective drugs in recovering neurological impairment of patients with stroke is always the hotspot in clinics.…”

Section: Introductionmentioning

confidence: 99%

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Nerve growth factor in combination with Oxiracetam in the treatment of Hypertensive Cerebral Hemorrhage

Sun

Zhang

2018

Pak J Med Sci

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Objective:To compare the clinical efficacy of nerve growth factor (NGF) in combination with oxiracetam and single use of oxiracetam in the treatment of hypertensive cerebral hemorrhage.Methods:One hundred and forty patients with hypertensive cerebral hemorrhage who were admitted to the hospital from July 2015 to September 2016 were selected as research subjects and randomly divided into a treatment group which was treated by NGF in combination with oxiracetam and a control group which was treated by oxiracetam only. The clinical efficacy was observed, and the death of both groups was recorded.Results:The National Institutes of Health Stroke Scale (NIHSS) score, Glasgow Coma Scale (GCS) score and limbs muscle force of both groups improved after treatment, and the improvement of the treatment was superior to that of the control group, suggesting a significant difference (P<0.05). The reduction of serum inflammatory factor level of the treatment group was much larger than that of the control group after treatment, and the difference had statistical significance (P<0.05). The survival analysis suggested that the survival rates of the two groups had a statistically significant difference (P<0.05).Conclusion:NGF in combination with oxiracetam is significantly effective in treating hypertensive cerebral hemorrhage as it can apparently recover neurologic impairment and limbs muscle force. The therapy has important clinical application values.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nerve growth factor in combination with Oxiracetam in the treatment of Hypertensive Cerebral Hemorrhage

Sun

Zhang

2018

Pak J Med Sci

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“…Stroke is clinically defined as interrupted or reduced blood flow to the brain, which results in functional impairments . Cerebral stroke can be categorized into three types: Ischemic (clots or thrombus) stroke occurs due to obstruction inside a blood vessel Hemorrhagic (bleeds) stroke occurs due to leakage or rupture of blood vessels Transient ischemic attack (TIA) is caused by a temporary clot. …”

Section: Curcumin In Neurodegenerative Diseasesmentioning

confidence: 99%

Benefits of curcumin in brain disorders

et al. 2019

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Curcumin is widely consumed in Asia either as turmeric directly or as one of the culinary ingredients in food recipes. The benefits of curcumin in different organ systems have been reported extensively in several neurological diseases and cancer. Curcumin has got its global recognition because of its strong antioxidant, anti‐inflammatory, anti‐cancer, and antimicrobial activities. Additionally, it is used in diabetes and arthritis as well as in hepatic, renal, and cardiovascular diseases. Recently, there is growing attention on usage of curcumin to prevent or delay the onset of neurodegenerative diseases. This review summarizes available data from several recent studies on curcumin in various neurological diseases such as Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Huntington's disease, Prions disease, stroke, Down's syndrome, autism, Amyotrophic lateral sclerosis, anxiety, depression, and aging. Recent advancements toward increasing the therapeutic efficacy of curcuma/curcumin formulation and the novel delivery strategies employed to overcome its minimal bioavailability and toxicity studies have also been discussed. This review also summarizes the ongoing clinical trials on curcumin for different neurodegenerative diseases and patent details of curcuma/curcumin in India.

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“…Stroke, is the condition of neurological defects attributed acute focal vascular injury by obstruction of blood vessel in central nervous system include cerebral infraction and cerebral hemorrhage (1). Hemorrhagic stroke is rupture of blood vessel in focal region of the brain and spills of blood in surrounding area of brain parenchyma (2). Collected hematoma increase intracranial pressure then cause neuronal injury (3).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Lipid Profile in Hemorrhagic Stroke Patients

Shrivastav¹,

Singh²,

Kushwaha³

et al. 2019

EJMR

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The relation between lipid profile and hemorrhagic stroke is controversial till now. Many epidemiological studies show inverse association of total cholesterol and triglycerides with hemorrhagic stroke. We analyze diagnostic role of lipid profile parameter in hemorrhagic stroke via case control study. The aim was to investigate lipid profile in hemorrhagic stroke patients and healthy control persons. Total 100 subject's case and control were included in this study and divided in two groups. 50 are hemorrhagic stroke patients and 50 are healthy control. Patients age <18, renal and hepatic impairment and familial hypercholesterolemia and hyperthyroidism were excluded. The inclusion of age group was between (64.8±11.9) and (48.9 ±9.9). Statistical analysis was done by using SPSS version 21.0. p value was calculated by ANOVA unpaired t-test. The p<0.05 was considered a statistically significant. The mean value of Total cholesterol (p=0.0001*) and Triglycerides (p=0.0254) were significantly low in hemorrhagic stroke patients compared with healthy control respectively. The mean LDL-C and VLDL-C were also significantly low in hemorrhagic stroke compared to healthy individuals (p=0.016 and p=0.025) respectively. Similarly, the mean HDL-C was also low in hemorrhagic stroke patients compare to healthy individuals. The hemorrhagic stroke patient's serum total cholesterol and triglycerides (r=-0.0854,p=0.0001 and r=-0.200 and p=0.046) were show significantly negative correlation with healthycontrol. The LDL-C and VLDL-C (r=-0.121 p=0.230 and r=-0.200, p=0.460) were show non-significant negative association in hemorrhagic stroke compare to healthy control respectively. HDL-C of hemorrhagic stroke patient's shows positively non-significantly associated with healthy control (r=0.0891, p=0.3785). This present study concluded that lipid profile levels play significant diagnostic role in hemorrhagic stroke patients. The lower concentration of total cholesterol and triglycerides may predispose individual towards the higher risk of hemorrhagic stroke.

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Brain Ischemia in Patients with Intracranial Hemorrhage: Pathophysiological Reasoning for Aggressive Diagnostic Management

Abstract: SUMMARY -

Cited by 15 publications

References 229 publications

Nerve growth factor in combination with Oxiracetam in the treatment of Hypertensive Cerebral Hemorrhage

Nerve growth factor in combination with Oxiracetam in the treatment of Hypertensive Cerebral Hemorrhage

Benefits of curcumin in brain disorders

Diagnostic Value of Lipid Profile in Hemorrhagic Stroke Patients

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