Brain involvement in a Schistosoma mansoni myelopathy patient

Artal, Francisco Javier Carod; Mesquita, H M; Gepp, Ricardo de Amoreira; Antunes, J S; Kalil, Ricardo K.

doi:10.1136/jnnp.2005.078014

Cited by 23 publications

(14 citation statements)

References 2 publications

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“…MR of the spinal cord can show enlargement of the middle and lower thoracic spinal cord in the acute phase on T1-weighted images, hyperintense areas on the T2-weighted sequence, heterogeneous areas of intramedullary contrast enhancement following intravenous gadolinium injection on T1-weighted sequence, and swelling of the conus medullaris with irregular enhancement. 66,75,76 Previous reports have described a similar variable enhancement pattern, using such terms as diffuse, spotty, or nodular. 77,78 In 1998, Bennett and Provenzale 78 described a nodular, peripheral spinal enhancement without a linear central enhancement.…”

Section: Diagnostic Criteriamentioning

confidence: 92%

“…Neither neuroimaging nor brain biopsy was performed. Artal et al 66 reported the case of a 65-year-old man who developed an inflammatory myeloradiculopathy and presented shortly thereafter with various episodes of seizures. Brain magnetic resonance (MR) imaging showed a left frontalparietal lesion with the "arborized" appearance firstly described by Sanelli et al 67 Brain biopsy confirmed the schistosomal infection, and the patient was treated with praziquantel and dexamethasone.…”

Section: Encephalomyelitismentioning

confidence: 98%

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Neuroschistosomiasis mansoni

Vale

Sousa-Pereira²,

Ribas³

et al. 2012

The Neurologist

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Section: Diagnostic Criteriamentioning

confidence: 92%

Section: Encephalomyelitismentioning

confidence: 98%

Neuroschistosomiasis mansoni

Vale

Sousa-Pereira²,

Ribas³

et al. 2012

The Neurologist

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“…Collections of Schistosoma eggs can be detected in brain parenchyma, cerebellum, leptomeninges, brain stem and choroids plexus. The main recipients for egg embolism are the cerebral cortex and leptomeninges [20]. Pathological studies have found that brain deposition of schistosomal eggs does not always cause significant granulomatous tissue reaction [18].…”

Section: Pathogenesis Of Cerebral Schistosomiasismentioning

confidence: 99%

Neuroschistosomiasis

Carod-Artal¹

2010

Expert Review of Anti-infective Therapy

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Neuroschistosomiasis, the infection of the CNS by Schistosoma spp., is a neglected and under-recognized complication of schistosomiasis. Cerebral and spinal neuroschistosomiasis can provoke severe disability. Neurological symptoms occur as a consequence of the immune reaction around the eggs deposited in the CNS. Cerebral neuroschistosomiasis may present with altered sensorium, headache, seizures and focal neurological deficit. Pseudotumoral and cerebellar neuroschistosomiasis may provoke intracranial hypertension and hydrocephalus. Brain-enhancing lesions with associated mass effect can be observed on MRI. Transverse myelitis and myeloradiculopathy affecting the conus medullaris and/or cauda equina are the most common spinal cord syndromes. Transverse myelitis can present as flaccid arreflexic paraplegia with sensory level and sphincter dysfunction. Praziquantel and corticoids have been successfully used to treat neuroschistosomiasis. Ventricle-peritoneal shunt may be necessary to treat hydrocephalus associated with tumor-like brain and/or cerebellar schistosomiasis.

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“…The autopsy studies find that S. haematobium and S. mansoni adult worms could invade the leptomeningeal or the pia mater in the subarachnoid space of spinal cord [6,8,13,14] . Besides, S. japonicum adult worms have also been found in the cerebral vein in the experimental monkeys [9,17] .…”

Section: The Ectopic Migration Of Adult Worms This Hypothesismentioning

confidence: 99%

Research development of the pathogenesis pathways for neuroschistosomiasis

Wang

Chen

et al. 2010

Neurosci. Bull.

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Abstract:The infection of the central nervous system (CNS) by schistosome may or may not have clinical manifestations.When symptomatic, neuroschistosomiasis (NS) is one of the most severe presentations of schistosome infection. Among the NS symptoms, cerebral invasion is mostly caused by Schistosoma japonicum (S. japonicum), and the spinal cord symptoms are mainly caused by S. mansoni or S. haematobium. There are 2 main pathways by which schistosomes cause NS: egg embolism and worm migration, via either artery or vein system, especially the valveless perivertebral Batson's plexus. The adult worm migrates anomalously through the above pathways to the CNS where they lay eggs. Due to the differences in species of schistosomes and stages of infection, mechanisms vary greatly. The portal hypertension with hepatosplenic schistosomiasis also plays an important role in the pathogenesis. Here the pathways through which NS occurs in the CNS were reviewed.

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Brain involvement in a Schistosoma mansoni myelopathy patient

Cited by 23 publications

References 2 publications

Neuroschistosomiasis mansoni

Neuroschistosomiasis mansoni

Neuroschistosomiasis

Research development of the pathogenesis pathways for neuroschistosomiasis

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