Brain-invasive meningiomas: molecular mechanisms and potential therapeutic options

Qin, Chaoying; Huang, Meng; Pan, Yimin; Li, Yuzhe; Long, Wenyong; Liu, Qing

doi:10.1007/s10014-021-00399-x

Cited by 10 publications

(21 citation statements)

References 156 publications

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“…A deeper insight into the mechanisms of infiltrative growth can furthermore spark the development of innovative therapeutic approaches. In that respect, extracellular matrix degradation, cell adhesion and growth factors have been formulated as potential therapy targets [15].…”

Section: Discussionmentioning

confidence: 99%

“…Brain invasion in meningiomas involves a complex interplay between cell adhesion molecules, extracellular matrix, the basement membrane at the brain tumor interface and the stimulation of growth factors. For further details of a three-step process that involves degradation, migration and differentiation the reader is referred to the review by Qin et al [15]. In proteomic analysis the Wnt signaling cascade was identified as one of the significantly modulated pathways in meningioma and is involved in epithelialto-mesenchymal transition [16].…”

Section: Introductionmentioning

confidence: 99%

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Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring

Behling

Hempel

Schittenhelm

2021

Cancers

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Most meningiomas are slow growing tumors arising from the arachnoid cap cells and can be cured by surgical resection or radiation therapy in selected cases. However, recurrent and aggressive cases are also quite common and challenging to treat due to no established treatment alternatives. Assessment of the risk of recurrence is therefore of utmost importance and several prognostic clinical and molecular markers have been established. Additionally, the identification of invasive growth of meningioma cells into CNS tissue was demonstrated to lead to a higher risk of recurrence and was therefore integrated into the WHO classification of CNS tumors. However, the evidence for its prognostic impact has been questioned in subsequent studies and its exclusion from the next WHO classification proposed. We were recently able to show the prognostic impact of CNS invasion in a large comprehensive retrospective meningioma cohort including other established prognostic factors. In this review we discuss the growing experiences that have been gained on this matter, with a focus on the currently nonuniform histopathological assessment, imaging characteristics and intraoperative sampling as well as the overall outlook on the future role of this potential prognostic factor.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring

Behling

Hempel

Schittenhelm

2021

Cancers

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“…Behling et al [ 13 ] shrewdly analyzed a series of crucial aspects in this regard. Apart from ethical aspects of intraoperative histological sampling on the border between tumor and brain parenchyma, at times, surgical specimens collected to assess invasion lacked an effective infiltrative interface [ 26 ]. Several factors could also potentially influence intraoperative tumor sampling: first, tumor location as with skull-base meningioma, where the sampling may result risky and hazardous; second, the proximity of tumor to brain eloquent areas, where even the complete surgical resection may be technically demanding; third, the choice of surgical approach may lead to “maneuvering” difficulties.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Rooprai’s group [ 22 ] refuted the correlation between secreted protein acidic and rich in cysteine (SPARC) expression and BI in different grades of meningioma, as previously proposed by Rempel et al [ 56 ]. The use of staining techniques for glial fibrillary acidic protein (GFAP), CD44, and EMA (epithelial membrane antigen) showed to increase the sensitivity in BI detection [ 20 , 26 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Updated Systematic Review on the Role of Brain Invasion in Intracranial Meningiomas: What, When, Why?

Brunasso

Bonosi

Costanzo

et al. 2022

Cancers

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Several recent studies are providing increasing insights into reliable markers to improve the diagnostic and prognostic assessment of meningioma patients. The evidence of brain invasion (BI) signs and its associated variables has been focused on, and currently, scientific research is investing in the study of key aspects, different methods, and approaches to recognize and evaluate BI. This paradigm shift may have significant repercussions for the diagnostic, prognostic, and therapeutic approach to higher-grade meningioma, as long as the evidence of BI may influence patients’ prognosis and inclusion in clinical trials and indirectly impact adjuvant therapy. We intended to review the current knowledge about the impact of BI in meningioma in the most updated literature and explore the most recent implications on both clinical practice and trials and future directions. According to the PRISMA guidelines, systematic research in the most updated platform was performed in order to provide a complete overview of characteristics, preoperative applications, and potential implications of BI in meningiomas. Nineteen articles were included in the present paper and analyzed according to specific research areas. The detection of brain invasion could represent a crucial factor in meningioma patients’ management, and research is flourishing and promising.

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“…Similar to other central nervous system neoplasms, such as glioma, Nassiri reported that meningiomas could be classified into different molecular groups with distinct and prototypical biological features after a comprehensive analysis combining copy number, DNA methylation, and mRNA sequencing data ( 12 ), complementing existing WHO grades. Here, based on the most up-to-date biomedical research knowledge, we review the potential cellular biological mechanisms and molecules involved in the recurrence or progression of meningiomas from several perspectives, including the excessive proliferation of tumor cells, neo-angiogenesis, inhibition of apoptosis, immunogenicity, and genetic alterations involving chromosomes and genes related to meningiomas ( 3 , 13 ). Further, we summarize existing therapeutic targets and clinical trials for meningiomas’ treatment.…”

Section: Introductionmentioning

confidence: 99%

Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature

Peng

Yuan

et al. 2022

Front. Oncol.

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Meningiomas, the most frequent primary intracranial tumors of the central nervous system in adults, originate from the meninges and meningeal spaces. Surgical resection and adjuvant radiation are considered the preferred treatment options. Although most meningiomas are benign and slow-growing, some patients suffer from tumor recurrence and disease progression, eventually resulting in poorer clinical outcomes, including malignant transformation and death. It is thus crucial to identify these “high-risk” tumors early; this requires an in-depth understanding of the molecular and genetic alterations, thereby providing a theoretical foundation for establishing personalized and precise treatment in the future. Here, we review the most up-to-date knowledge of the cellular biological alterations involved in the progression of meningiomas, including cell proliferation, neo-angiogenesis, inhibition of apoptosis, and immunogenicity. Focused genetic alterations, including chromosomal abnormalities and DNA methylation patterns, are summarized and discussed in detail. We also present latest therapeutic targets and clinical trials for meningiomas' treatment. A further understanding of cellular biological and genetic alterations will provide new prospects for the accurate screening and treatment of recurrent and progressive meningiomas.

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Brain-invasive meningiomas: molecular mechanisms and potential therapeutic options

Cited by 10 publications

References 156 publications

Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring

Brain Invasion in Meningioma—A Prognostic Potential Worth Exploring

Updated Systematic Review on the Role of Brain Invasion in Intracranial Meningiomas: What, When, Why?

Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature

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