Brain imaging study of the acute effects of Δ9-tetrahydrocannabinol (THC) on attention and motor coordination in regular users of marijuana

Weinstein, Aviv; Brickner, O.; Lerman, Hedva; Greemland, M.; Bloch, Miki; Lester, Hava; Chisin, Roland; Mechoulam, Raphael; Bar-Hamburger, Rachel; Freedman, Nanette; Even-Sapir, Einat

doi:10.1007/s00213-007-0940-7

Cited by 48 publications

(30 citation statements)

References 59 publications

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“…Nevertheless, a greater rCBF increase from pre- to post-smoking in the chronic compared to occasional user group has been found in thalamus and cerebellum. Regular cannabis users [40] underwent an 18 FDG-PET scan analysis while applying a virtual reality maze task after the administration of 17mg delta-9-THC or placebo. More virtual wall hits under delta-9-THC have been accompanied by an increased brain metabolism during task performance in the middle and medial frontal cortices and anterior cingulate, while a reduced metabolism was found in the occipital lobes.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings

Wrege¹,

Schmidt²,

Walter³

et al. 2014

CPD

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We conducted a systematic review to assess the evidence for specific effects of cannabis on impulsivity, disinhibition and motor control. The review had a specific focus on neuroimaging findings associated with acute and chronic use of the drug and covers literature published up until May 2012. Seventeen studies were identified, of which 13 met the inclusion criteria; three studies investigated acute effects of cannabis (1 fMRI, 2 PET), while six studies investigated non-acute functional effects (4 fMRI, 2 PET), and four studies investigated structural alterations. Functional imaging studies of impulsivity studies suggest that prefrontal blood flow is lower in chronic cannabis users than in controls. Studies of acute administration of THC or marijuana report increased brain metabolism in several brain regions during impulsivity tasks. Structural imaging studies of cannabis users found differences in reduced prefrontal volumes and white matter integrity that might mediate the abnormal impulsivity and mood observed in marijuana users. To address the question whether impulsivity as a trait precedes cannabis consumption or whether cannabis aggravates impulsivity and discontinuation of usage more longitudinal study designs are warranted.

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Section: Resultsmentioning

confidence: 99%

“…During the task, marijuana users showed significantly higher ACC activity compared to healthy controls [40]. Furthermore, an earlier onset of cannabis use was associated with more commission errors compared to late onset users concomitant with more focal clusters.…”

Section: Resultsmentioning

confidence: 99%

Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings

Wrege¹,

Schmidt²,

Walter³

et al. 2014

CPD

View full text Add to dashboard Cite

show abstract

“…Marijuana (mainly dependent on the THC dose used) reduces visual scanning, orientation ability, divided attention and psychomotor performance (Weinstein et al, 2008;Ashton, 2001;Smiley, 1999). Ramaekers et al (2006) found that the proportion of observations showing impairment of cognition and motor control progressively increased as a function of serum THC in different tasks.…”

Section: Introductionmentioning

confidence: 98%

The effect of alcohol, THC and their combination on perceived effects, willingness to drive and performance of driving and non-driving tasks

Ronen¹,

Chassidim²,

Gershon³

et al. 2010

Accident Analysis & Prevention

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“…More specifically, both acute and chronic doses of THC have been shown to cause impairment in attention and motor coordination in a maze task in humans [49], inhibition of movement and basal ganglia neuronal activity in adult rats [43], decreased locomotor activity in rats [51], and impaired spatial and non-spatial memory in adolescent and adult rats and mice [8, 27, 31, 34]. These effects can become increasingly severe the earlier in life the individual begins to use marijuana [33, 34], and are often greater in adolescents than in adults [8].…”

Section: Introductionmentioning

confidence: 99%

Sexually dimorphic alterations in locomotion and reversal learning after adolescent tetrahydrocannabinol exposure in the rat

Harte¹,

Dow-Edwards²

2010

Neurotoxicology and Teratology

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Research suggests that use and abuse of marijuana can be especially harmful if it occurs during adolescence, a period of vast developmental changes throughout the brain. We examined the effects of 2 mg/kg Δ9-tetrahydrocannabinol (THC) administered daily via intra-peritoneal injections during juvenile/early adolescence (postnatal day 22–40) or late adolescence (postnatal day 41–60) on locomotor activity, development of tolerance, and acquisition/retention of spatial avoidance in adulthood. THC caused locomotor depression in both male and female animals dosed during early adolescence but only in female animals dosed during late adolescence. Evidence of reverse tolerance to THC was seen in early adolescent animals only. In the active place avoidance test (APA), male and female animals administered THC during early adolescence made more errors on the reversal trial requiring flexibility in learning, but in animals dosed during late adolescence there were no significant sex or treatment differences. The results of the locomotor activity study indicate that females may be more sensitive to the effects of THC than males, while results of both locomotor activity and APA studies suggest that early adolescents appear to be more vulnerable to these effects than late adolescents/young adults.

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Brain imaging study of the acute effects of Δ9-tetrahydrocannabinol (THC) on attention and motor coordination in regular users of marijuana

Abstract: These findings suggest that in regular marijuana users, the immediate effects of marijuana may impact on cognitive-motor skills and brain mechanisms that modulate coordinated movement and driving.

Cited by 48 publications

References 59 publications

Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings

Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings

The effect of alcohol, THC and their combination on perceived effects, willingness to drive and performance of driving and non-driving tasks

Sexually dimorphic alterations in locomotion and reversal learning after adolescent tetrahydrocannabinol exposure in the rat

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