Brain Imaging in Fibromyalgia

Jorge, Liliana Lourenço; Amaro, Edson

doi:10.1007/s11916-012-0284-9

Cited by 25 publications

(16 citation statements)

References 71 publications

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“…It has been suggested that FM is related to altered somatosensory and nociceptive input to the brain, either via increased sensory input and/or reduced inhibition of the input (Clauw, 2009 ; Brederson et al, 2011 ; Smith et al, 2011 ). This hypothesis has been supported by recent resting state functional magnetic resonance imaging (rsfMRI) studies that found alterations in brain function and connectivity in FM patients (Nebel and Gracely, 2009 ; Jorge and Amaro, 2012 ). rsfMRI is an imaging method to evaluate brain function when a subject is not engaged in an explicit task and it has been widely used to study the neurophysiological basis for FM pain and analgesia as it is capable of probing the low-frequency fluctuations (LFFs) of the blood oxygen level-dependent (BOLD) signal across the whole brain and patterns of functional connectivity can be inferred between brain areas across time, without the need of an specific task (Greicius et al, 2003 ).…”

Section: Introductionmentioning

confidence: 75%

Music reduces pain and increases resting state fMRI BOLD signal amplitude in the left angular gyrus in fibromyalgia patients

et al. 2015

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Music reduces pain in fibromyalgia (FM), a chronic pain disease, but the functional neural correlates of music-induced analgesia (MIA) are still largely unknown. We recruited FM patients (n = 22) who listened to their preferred relaxing music and an auditory control (pink noise) for 5 min without external noise from fMRI image acquisition. Resting state fMRI was then acquired before and after the music and control conditions. A significant increase in the amplitude of low frequency fluctuations of the BOLD signal was evident in the left angular gyrus (lAnG) after listening to music, which in turn, correlated to the analgesia reports. The post-hoc seed-based functional connectivity analysis of the lAnG showed found higher connectivity after listening to music with right dorsolateral prefrontal cortex (rdlPFC), the left caudate (lCau), and decreased connectivity with right anterior cingulate cortex (rACC), right supplementary motor area (rSMA), precuneus and right precentral gyrus (rPreG). Pain intensity (PI) analgesia was correlated (r = 0.61) to the connectivity of the lAnG with the rPreG. Our results show that MIA in FM is related to top-down regulation of the pain modulatory network by the default mode network (DMN).

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Section: Introductionmentioning

confidence: 75%

Music reduces pain and increases resting state fMRI BOLD signal amplitude in the left angular gyrus in fibromyalgia patients

et al. 2015

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“…The first neuroimaging studies in FMS used positron emission tomography (PET) and single photon emission computed tomography (SPECT) and demonstrated reduced basal regional cerebral blood flow (rCBF), indicative of decreased neural activity, particularly in the thalamus and caudate nucleus [280,281].…”

Section: Regional Cerebral Flood Flowmentioning

confidence: 99%

Fibromyalgia: A Critical and Comprehensive Review

Borchers

Gershwin

2015

Clinic Rev Allerg Immunol

225

217

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Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise classification. It is often considered as part of the global overview of functional somatic syndromes that are otherwise medically unexplained or part of a somatization disorder. Patients with fibromyalgia share symptoms with other functional somatic problems, including issues of myalgias, arthralgias, fatigue and sleep disturbances. Indeed, there is often diagnostic and classification overlap for the case definitions of a variety of somatization disorders. Fibromyalgia, however, is a critically important syndrome for physicians and scientists to be aware of. Patients should be taken very seriously and provided optimal care. Although inflammatory, infectious, and autoimmune disorders have all been ascribed to be etiological events in the development of fibromyalgia, there is very little data to support such a thesis. Many of these disorders are associated with depression and anxiety and may even be part of what has been sometimes called affected spectrum disorders. There is no evidence that physical trauma, i.e., automobile accidents, is associated with the development or exacerbation of fibromyalgia. Treatment should be placed on education, patient support, physical therapy, nutrition, and exercise, including the use of drugs that are approved for the treatment of fibromyalgia. Treatment should not include opiates and patients should not become poly pharmacies in which the treatment itself can lead to significant morbidities. Patients with fibromyalgia are living and not dying of this disorder and positive outlooks and family support are key elements in the management of patients.

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“…It has been attributed to dysfunctional descending μ-opioid antinociceptive pathways, rather than increased ascending nociceptive inputs. Multiple functional imaging studies support this theory, in which brain areas involved in central pain processing are differently activated in fibromyalgia patients (12).…”

Section: Introductionmentioning

confidence: 94%