Laser-Evoked Potentials in Fibromyalgia: The Influence of Greater Occipital Nerve Stimulation on Cerebral Pain Processing

Plazier, Mark; Ost, Jan; Snijders, Erwin; Gilbers, Martijn; Vancamp, Tim; Ridder, Dirk De; Vanneste, Sven

doi:10.1111/ner.12310

Cited by 5 publications

(5 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to this, electrophysiology and functional magnetic resonance imaging, revealed an abnormally increased reactivity of cortical regions of the pain network involved, at different extent, in pain perception and processing like medial prefrontal and insular areas, sensory and motor cortex and cerebellum, while a decreased activity and connectivity was found in areas and network exerting inhibitory control on nociceptive input like rostral anterior cingulate regions (Gracely et al, 2002; Diers et al, 2008; de Tommaso, 2008; Jensen et al, 2013; Plazier et al, 2015; Truini et al, 2015; Lopez-Sola et al, 2017; Sawaddiruk et al, 2017). In line with these observations, FMS patients showed also abnormalities of functional connectivity in Default mode network (DMN) mainly affecting the referential DMN and the executive control network (Pujol et al, 2014).…”

Section: Pathophysiology Of Fibromyalgia and Potential Targets For Nementioning

confidence: 87%

Brain Modulation by Electric Currents in Fibromyalgia: A Structured Review on Non-invasive Approach With Transcranial Electrical Stimulation

Brighina

Curatolo

Cosentino

et al. 2019

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Fibromyalgia syndrome (FMS) is a complex disorder where widespread musculoskeletal pain is associated with many heterogenous symptoms ranging from affective disturbances to cognitive dysfunction and central fatigue. FMS is currently underdiagnosed and often very poorly responsive to pharmacological treatment. Pathophysiology of the disease remains still obscure even if in the last years fine structural and functional cerebral abnormalities have been identified, principally by neurophysiological and imaging studies delineating disfunctions in pain perception, processing and control systems. On such basis, recently, neurostimulation of brain areas involved in mechanism of pain processing and control (primary motor cortex: M1 and dorsolateral prefrontal cortex: DLPFC) has been explored by means of different approaches and particularly through non-invasive brain stimulation techniques (transcranial magnetic and electric stimulation: TMS and tES). Here we summarize studies on tES application in FMS. The great majority of reports, based on direct currents (transcranial direct currents stimulation: tDCS) and targeting M1, showed efficacy on pain measures and less on cognitive and affective symptoms, even if several aspects as maintenance of therapeutical effects and optimal stimulation parameters remain to be established. Differently, stimulation of DLPFC, explored in a few studies, was ineffective on pain and showed limited effects on cognitive and affective symptoms. Very recently new tES techniques as high-density tDCS (HD-tDCS), transcranial random noise stimulation (tRNS) and tDCS devices for home-based treatment have been explored in FMS with interesting even if very preliminary results opening interesting perspectives for more effective, well tolerated, cheap and easy therapeutic approaches.

show abstract

Section: Pathophysiology Of Fibromyalgia and Potential Targets For Nementioning

confidence: 87%

Brain Modulation by Electric Currents in Fibromyalgia: A Structured Review on Non-invasive Approach With Transcranial Electrical Stimulation

Brighina

Curatolo

Cosentino

et al. 2019

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Furthermore, tDCS can be used to modulate noninvasively the occipital nerve field producing similar results to the implants [5,23], and can predict the results of subsequent subcutaneous occipital nerve field stimulation via implanted electrodes [5]. Occipital nerve field stimulation has a direct impact on the latencies of the laser evoked potentials in patients with fibromyalgia, confirming that this type stimulation alters the processing of the painful stimulus at a central level [24]. During occipital nerve field stimulation, functional magnetic resonance imaging and PET data have demonstrated that activity in the pregenual and dorsal anterior cingulate cortex, insula, somatosensory cortex, and ventroposterolateral nuclei of the thalamus are effectively modulated in healthy subjects [8,25].…”

Section: Introductionmentioning

confidence: 84%

Occipital Nerve Field Transcranial Direct Current Stimulation Normalizes Imbalance Between Pain Detecting and Pain Inhibitory Pathways in Fibromyalgia

Ridder

Vanneste

2017

Neurotherapeutics

Self Cite

View full text Add to dashboard Cite

Occipital nerve field (OCF) stimulation with subcutaneously implanted electrodes is used to treat headaches, more generalized pain, and even failed back surgery syndrome via unknown mechanisms. Transcranial direct current stimulation (tDCS) can predict the efficacy of implanted electrodes. The purpose of this study is to unravel the neural mechanisms involved in global pain suppression, mediated by occipital nerve field stimulation, within the realm of fibromyalgia. Nineteen patients with fibromyalgia underwent a placebo-controlled OCF tDCS. Electroencephalograms were recorded at baseline after active and sham stimulation. In comparison with healthy controls, patients with fibromyalgia demonstrate increased dorsal anterior cingulate cortex, increased premotor/dorsolateral prefrontal cortex activity, and an imbalance between pain-detecting dorsal anterior cingulate cortex and pain-suppressing pregenual anterior cingulate cortex activity, which is normalized after active tDCS but not sham stimulation associated with increased pregenual anterior cingulate cortex activation. The imbalance improvement between the pregenual anterior cingulate cortex and the dorsal anterior cingulate cortex is related to clinical changes. An imbalance assumes these areas communicate and, indeed, abnormal functional connectivity between the dorsal anterior cingulate cortex and pregenual anterior cingulate cortex is noted to be caused by a dysfunctional effective connectivity from the pregenual anterior cingulate cortex to the dorsal anterior cingulate cortex, which improves and normalizes after real tDCS but not sham tDCS. In conclusion, OCF tDCS exerts its effect via activation of the descending pain inhibitory pathway and de-activation of the salience network, both of which are abnormal in fibromyalgia.

show abstract

“…Several changes in the LEPs are shown that fibromyalgia patients tend to have lower pain thresholds and higher N2 amplitudes. [ 31 ] So the amplitudes of LEPs correlate with the subjective perception of the intensity of pain. In this study, the magnitude of LEPs was used to assess the index of the subjective pain experience accurately and it is also helpful to identify psychogenic pain.…”

Section: Discussionmentioning

confidence: 99%

Clinical study of repetitive transcranial magnetic stimulation of the motor cortex for thalamic pain

Hua¹,

Li²,

et al. 2018

Medicine

View full text Add to dashboard Cite

Thalamic pain is a severe pain that is often unresponsive to medical therapy. Repetitive transcranial magnetic stimulation (rTMS) entirely non-invasively modulates neuronal plasticity to produce therapeutic benefit. Since the rTMS stimulation parameters varied, it is difficult to determine which specific parameters are best for clinical use. The aim of this study was to evaluate the analgesic lasting effect of 10-Hz rTMS over the motor cortex (M1) for 10 consecutive days to treat thalamic pain.Patients were treated with daily 10-Hz rTMS sessions for 1000 pulses applied over the M1 for 10 consecutive days. Pain severity and mood were assessed at baseline, immediately after, 2 weeks, 4 weeks, 6 weeks, 8 weeks after rTMS. Pain severity was measured by the visual analogue scale (VAS) and the percentage of pain relief on VAS score was calculated between baseline and final examination. Mood was monitored using the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD).Seven patients with thalamic pain were enrolled. VAS score was significantly decreased after rTMS. Mean VAS scores were 7 at baseline and decreased to 5.6 at 2 weeks after rTMS and then decreased to 3.9 at 8 weeks after rTMS. The analgesic effect of rTMS can last up to 8 weeks. The percentage of pain relief ranges from 25.0% to 66.7% at the 8th week. Four patients (3 moderate pain and 1 severe pain) achieved satisfactory relief (pain relief ≥40–69%).Although this was an open-label study without a control group, our findings show that 10 Hz rTMS over the M1 for 10 consecutive days can produce satisfactory or partial antalgic effect on patients with thalamic pain.

show abstract

Laser-Evoked Potentials in Fibromyalgia: The Influence of Greater Occipital Nerve Stimulation on Cerebral Pain Processing

Cited by 5 publications

References 56 publications

Brain Modulation by Electric Currents in Fibromyalgia: A Structured Review on Non-invasive Approach With Transcranial Electrical Stimulation

Brain Modulation by Electric Currents in Fibromyalgia: A Structured Review on Non-invasive Approach With Transcranial Electrical Stimulation

Occipital Nerve Field Transcranial Direct Current Stimulation Normalizes Imbalance Between Pain Detecting and Pain Inhibitory Pathways in Fibromyalgia

Clinical study of repetitive transcranial magnetic stimulation of the motor cortex for thalamic pain

Contact Info

Product

Resources

About