Brain imaging in childhood‐ and adolescence‐onset schizophrenia associated with obsessive‐compulsive symptoms

Aoyama, Fukiko; Iida, Junzo; Inoue, Makoto; Iwasaka, Hidemi; Sakiyama, Shinobu; Hata, Kazuya; Kishimoto, Toshifumi

doi:10.1034/j.1600-0447.2000.102001032.x

Cited by 44 publications

(26 citation statements)

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“…Magnetic resonance imaging studies have identified significantly reduced volumes in the left hippocampus, frontal lobes (Aoyama et al 2000) and anterior horn of the lateral and third ventricle (Goldstein et al 1999) for schizophrenia patients with OCS when compared with their schizophrenia counterparts without OCS. Additionally, schizo-obsessive patients show more neurological signs (Sevincok et al 2004), motor symptoms including catatonia, loss of motor ability or hyperactive motor activity (Tibbo et al 2000) and extrapyramidal symptoms (Kruger et al 2000 ;Ohta et al 2003 ;Mukhopadhaya et al 2009) compared with schizophrenia subjects ; and more tics when compared with patients with OCD (Poyurovsky et al 2006).…”

Section: Introductionmentioning

confidence: 99%

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

et al. 2009

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Background. Interest in the neuro-cognitive profile of patients with schizophrenia and co-morbid obsessive compulsive disorder (schizo-OCD) is rising in response to reports of high co-morbidity rates. Whereas schizophrenia has been associated with global impairment in a wide range of neuro-cognitive domains, OCD is associated with specific deficits featuring impaired performance on tasks of motor and cognitive inhibition involving frontostriatal neurocircuitry.Method. We compared cognitive function using the CANTAB battery in patients with schizo-OCD (n=12) and a schizophrenia group without OCD symptoms (n=16). The groups were matched for IQ, gender, age, medication, and duration of illness.Results. The schizo-OCD patients made significantly more errors on a task of attentional set-shifting (ID-ED set-shift task). By contrast, no significant differences emerged on the Stockings of Cambridge task, the Cambridge Gamble Task or the Affective Go/NoGo tasks. No correlation emerged between ID-ED performance and severity of schizophrenia, OCD or depressive symptoms, consistent with neurocognitive impairment holding trait rather than statemarker status. Schizo-obsessives also exhibited a trend toward more motor tics emphasizing a neurological contribution to the disorder. Conclusion.Our findings reveal a more severe attentional set-shifting deficit and neurological abnormality that may be fundamental to the neuro-cognitive profile of schizo-OCD. The clinical implications of these impairments merit further exploration in larger studies.

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Section: Introductionmentioning

confidence: 99%

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

et al. 2009

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“…Another MRI study, conducted in 2000 by Aoyama et al [17], found significantly reduced volumes of the left hippocampus, frontal lobes and anterior horn of the lateral and third ventricles in the schizo-obsessive group (n = 15) compared to the SCZ group (n = 17) and healthy controls (HC; n = 19); an inverse correlation between illness duration and frontal lobe size was also found in schizo-obsessive patients but not in SCZ patients. …”

Section: Resultsmentioning

confidence: 99%

“…One [9] of the above-mentioned original research articles was discarded as unrelated to the topic. In addition to our PubMed search, another 4 relevant neuroimaging studies in schizo-obsessive disorder (all original research reports) were also included in this report, based on our knowledge of the subject [16,17,18,19]. All articles were written in the English language.…”

Section: Methodsmentioning

confidence: 99%

Schizo-Obsessive Disorder: A Brief Report of Neuroimaging Findings

Attademo

Bernardini²,

Quartesan³

2016

Psychopathology

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Background: The term ‘schizo-obsessive disorder' was coined to describe schizophrenia (SCZ) patients who are also affected by obsessive-compulsive symptoms (OCS) or also meet the criteria for obsessive-compulsive disorder (OCD). Several studies have investigated the clinical and epidemiological features of OCS/OCD in SCZ, but the neuroimaging literature is sparse. The aim of this brief report is to describe some of the most important neuroimaging findings regarding schizo-obsessive disorder. Methods: A literature search of the PubMed electronic database was conducted up to July 25, 2015. Search terms included ‘schizo-obsessive' combined with the names of specific neuroimaging techniques. Results: Neuroimaging studies suggest that there may be a specific pattern of neuroanatomic dysfunction in schizo-obsessive patients, but the number of studies is limited and conclusions are preliminary because reports are of an exploratory nature. Conclusions: Further neurobiological research is needed to definitely determine whether schizo-obsessive disorder might have unique neuroanatomical and functional alterations.

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“…[5] Obsesif-kompulsif belirtileri olan erken başlangıçlı şizofreni hastalarının manyetik rezonans gö-rüntüleme (MRI) çalışmalarında obsesif-kompulsif belirtileri olmayan şizofre-ni grubuna ve kontrol grubuna göre anlamlı derecede küçük sol hippokampus belirlenmiştir. [40] Bu araştırmacılar obsesif-kompulsif belirtileri olan şizofreni grubunda, obsesif-kompulsif belirtileri olmayan gruptan farklı olarak; hastalık süresi ile frontal lob büyüklüğü arasında ters yönde bir ilişki olduğunu bulmuşlardır. Bu anlamda bu hastaların frontal lob atrofisi açısından yatkınlık geliştirdikleri ileri sürülmektedir.…”

Section: Nöro-görüntüleme çAlışmalarıunclassified

Schizo-obsessive Disorder

Gelegen¹,

Tamam²

2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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Obsessive-compulsive features are common in schizophrenia. Current genetic, neurobiological, clinical and epidemiological data about obsessive-compulsive symptoms/disorder in schizophrenia suppose that schizophrenia combined with OCD is more than a mere comorbidity. Epidemiologic and neurobiological evidence suggest that the patients with comorbid OCD and schizophrenia may present a special category among patients with schizophrenia. Although a specific profile has not been emerged yet; clinical, neurobiological research about schizo-obsessive patients have been extensively pursued.

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Brain imaging in childhood‐ and adolescence‐onset schizophrenia associated with obsessive‐compulsive symptoms

Abstract: Reduced size of the left hippocampus in the SOCS+ group supports a neurodevelopmental etiology in this subgroup.

Cited by 44 publications

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The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

Schizo-Obsessive Disorder: A Brief Report of Neuroimaging Findings

Schizo-obsessive Disorder

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