Brain functional changes in patients with Crohn's disease: A resting‐state fMRI study

Li, Lü; Ma, Jie; Xu, Jian‐Guang; Zheng, Yi; Xie, Qian; Liu, Rong; Liang, Zonghui

doi:10.1002/brb3.2243

Cited by 23 publications

(23 citation statements)

References 75 publications

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“…Similar changes were found for ulcerative colitis (25). In inactive CD patients, the ReHo values in the superior frontal gyrus, putamen, anterior cingulate and supplementary motor areas were altered in other study (15,26,27). In addition, Bao et al found that the gray matter volumes in CD patients were changed in that brain region (8), which suggested that CD patients have abnormal brain activity and morphology.…”

Section: Discussionmentioning

confidence: 90%

Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study

Huang

Fan

et al. 2022

Front. Neurol.

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Abnormal psychological processing in the central nervous system has been found in Crohn's disease (CD) patients. Resting-state functional magnetic resonance images of 57 inactive and 58 active CD patients, and 92 healthy controls (HC) were obtained. The psychological assessment used a psychological questionnaire that was collected within 1 week before functional MRI examination. We investigated the neural basis of CD patients and the correlation among regional homogeneity (ReHo), clinical features and psychological assessment scores. We found that more severe psychological assessment disorder scores were observed in the active CD group than in the inactive CD group and HC group (P<0.001). Compared with HC, the active CD patients exhibited higher ReHo values in the frontal superior medial, frontal middle and lower values in the postcentral, supplementary motor area, and temporal middle. Meanwhile, inactive CD patients exhibited higher ReHo values in the frontal middle and lower ReHo values in the precentral, postcentral and putamen (all voxel P< 0.001, cluster P<0.01, corrected). The values of the frontal superior medial, postcentral and supplementary motor area were correlation with psychological assessment scores (r = 0.38, −0.41, −0.32, P = 0.001, 0.014, 0.003), and the clinical features of simple endoscopic score for Crohn's disease and erythrocyte sedimentation rate were negatively correlated with psychological assessment scores in active CD patients (r = −0.35, −0.34, P = 0.06, 0.08). These results provide evidence for abnormal resting-state brain activity in CD and suggest that the psychological of CD may play a critical role in brain function.

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Section: Discussionmentioning

confidence: 90%

Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study

Huang

Fan

et al. 2022

Front. Neurol.

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“…Both postcentral and precentral gyri are involved in pain processing, which is a multidimensional experience involving sensory discrimination, cognition evaluation, and affective motivation [30]. A large number of researches have proven the essential roles of the postcentral and precentral gyri in chronic pain-related [17,18,31]. Therefore, we hold the opinion that the decreased neural activity in the postcentral and precentral gyri may be associated with angina pectoris.…”

Section: Disease Markersmentioning

confidence: 96%

“…In contrast with the amplitude of low-frequency fluctuations (ALFF), fALFF can effectively suppress physiological noise, decrease interference with cerebrospinal fluid, and show high sensitivity to detect spontaneous neural activity [16]. In recent years, ALFF and fALFF analyses have been widely applied in a series of neuropsychiatric disorders and have been used in the research on pain mechanisms, showing abnormalities of neural activity in pain-related diseases such as Crohn's disease, irritable bowel syndrome, and chronic low back pain [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Aberrant Spontaneous Brain Activity in Coronary Heart Disease Using Fractional Amplitude of Low-Frequency Fluctuations: A Preliminary Resting-State Functional MRI Study

et al. 2022

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Objective. This study is aimed at exploring the spontaneous brain activity changes by measuring the fractional amplitude of low-frequency fluctuations (fALFF) and their relationship with clinical characteristics in patients with coronary heart disease (CHD). Methods. Coronary heart disease patients ( n = 25 ) and age, gender, and education level-matched control subjects (controls, n = 35 ) were included. The grey matter volume (GMV) and fALFF values were calculated to assess the difference in brain structure and function between the two groups, respectively. Correlation analyses between the fALFF values and clinical characteristics were further assessed in CHD patients. In addition, receiver operating characteristic (ROC) curves were conducted to access the diagnostic ability of the fALFF method. Results. There was no significant difference in GMV between the CHD and control groups. Compared with the control group, patients with CHD showed significantly decreased fALFF in the left precentral/postcentral gyrus and increased fALFF in the right inferior cerebellum. Patients with a history of myocardial infarction (MI) showed significantly decreased fALFF values of the right inferior cerebellum than patients without MI. There was no significant correlation between the fALFF values in specific brain regions and disease duration. Furthermore, the ROC curves of abnormal brain regions showed the perfect accuracy of the fALFF value in distinguishing between CHD patients and controls. Conclusion. CHD demonstrated aberrant neural activity in specific brain regions mainly related to sensorimotor networks and pain processing, which may contribute to understanding the underlying neurological mechanism of CHD.

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“…By evaluating the amplitude of the BOLD signal relative to the baseline, ALFF analysis can reflect the degree of spontaneous activity of each voxel in the brain. In various brain regions of CD patients, including the insula, anterior cingulate gyrus, medial prefrontal cortex, precentral gyrus, secondary somatosensory cortex, and hippocampus cortex, studies have revealed that the ALFF values are different (34). The regulation of visceral sensation (pain) and movement is controlled by these brain regions, which are all parts of the visceral sensation and pain network.…”

Section: Alff Analysismentioning

confidence: 99%

Magnetic Resonance Neuroimaging of Inflammatory Bowel Disease

Tangsujaritvijit

2022

Sci Insights

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Inflammatory bowel disease (IBD) is a lifelong, relapsing, chronic inflammatory disease of the digestive tract that can be brought on by a number of different etiologies. Studies have shown that patients with IBD also have nervous system involvement in addition to well-known extra-intestinal symptoms like arthritis and iritis, and researchers believe that neurological lesions in patients with IBD may be an important extra-intestinal manifestation. Currently, tentative findings from studies employing magnetic resonance imaging to study the brain structure and function of patients with IBD have been made.

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Brain functional changes in patients with Crohn's disease: A resting‐state fMRI study

Abstract: contributed to the work equally and should be regarded as co-first authors.

Cited by 23 publications

References 75 publications

Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study

Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study

Aberrant Spontaneous Brain Activity in Coronary Heart Disease Using Fractional Amplitude of Low-Frequency Fluctuations: A Preliminary Resting-State Functional MRI Study

Magnetic Resonance Neuroimaging of Inflammatory Bowel Disease

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