Brain Electrical Activity After Acute Hippocampal Stimulation in Awake Rats

Amorim, Henrique Alves de; Cavalheiro, Ésper A.; Cukiert, Arthur

doi:10.1111/j.1525-1403.2012.00491.x

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…We previously showed that low‐frequency Hip‐DBS in the rat easily elicited bilateral hippocampal recruiting responses and that this was not noted in humans, in whom Hip‐DBS was able to trigger only ipsilateral local (temporal lobe) recruiting responses . This might be related to the relative relevance of the hippocampal commissure in the rat and in man; this structure is highly developed in the rat and vestigial in man.…”

Section: Discussionmentioning

confidence: 98%

c-FOS Expression After Hippocampal Deep Brain Stimulation in Normal Rats

Nejm

Cavalheiro

Cukiert

2014

Neuromodulation: Technology at the Neural Interface

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Section: Discussionmentioning

confidence: 98%

c-FOS Expression After Hippocampal Deep Brain Stimulation in Normal Rats

Nejm

Cavalheiro

Cukiert

2014

Neuromodulation: Technology at the Neural Interface

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“…LFS (2-10 Hz) may evoke a 'recruiting rhythm' on EEG especially in patients who showed seizure reduction with HFS [67][68][69][70]. An animal study showed such synchronized activity increases as the intensity of stimulation increases and finally can lead to complex partial seizures [71]. Their study also showed a progressive reduction in the response amplitude and disappearance of entrained responses as the stimulation frequency increases.…”

Section: Discussionmentioning

confidence: 99%

Control of epileptic seizures by electrical stimulation: a model-based study

Sohanian-Haghighi¹,

Markazi²

2021

Biomed. Phys. Eng. Express

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High frequency electrical stimulation of brain is commonly used in research experiments and clinical trials as a modern tool for control of epileptic seizures. However, the mechanistic basis by which periodic external stimuli alter the brain state is not well understood. This study provides a computational insight into the mechanism of seizure suppression by high frequency stimulation (HFS). In particular, a modified version of the Jansen-Rit neural mass model is employed, in which EEG signals can be considered as the input. The proposed model reproduces seizure-like activity in the output during the ictal period of the input signal. By applying a control signal to the model, a wide range of stimulation amplitudes and frequencies are systematically explored. Simulation results reveal that HFS can effectively suppress the seizure-like activity. Our results suggest that HFS has the ability of shifting the operating state of neural populations away from a critical condition. Furthermore, a closed-loop control strategy is proposed in this paper. The main objective has been to considerably reduce the control effort needed for blocking abnormal activity of the brain. Such an energy reduction could be of practical importance, to reduce possible side effects and increase battery life for implanted neurostimulators.

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Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders

Zhang,

Matin,

Gorodetsky

et al. 2024

Transl Psychiatry

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Deep brain stimulation (DBS) modulates local and widespread connectivity in dysfunctional networks. Positive results are observed in several patient populations; however, the precise mechanisms underlying treatment remain unknown. Translational DBS studies aim to answer these questions and provide knowledge for advancing the field. Here, we systematically review the literature on DBS studies involving models of neurological, developmental and neuropsychiatric disorders to provide a synthesis of the current scientific landscape surrounding this topic. A systematic analysis of the literature was performed following PRISMA guidelines. 407 original articles were included. Data extraction focused on study characteristics, including stimulation protocol, behavioural outcomes, and mechanisms of action. The number of articles published increased over the years, including 16 rat models and 13 mouse models of transgenic or healthy animals exposed to external factors to induce symptoms. Most studies targeted telencephalic structures with varying stimulation settings. Positive behavioural outcomes were reported in 85.8% of the included studies. In models of psychiatric and neurodevelopmental disorders, DBS-induced effects were associated with changes in monoamines and neuronal activity along the mesocorticolimbic circuit. For movement disorders, DBS improves symptoms via modulation of the striatal dopaminergic system. In dementia and epilepsy models, changes to cellular and molecular aspects of the hippocampus were shown to underlie symptom improvement. Despite limitations in translating findings from preclinical to clinical settings, rodent studies have contributed substantially to our current knowledge of the pathophysiology of disease and DBS mechanisms. Direct inhibition/excitation of neural activity, whereby DBS modulates pathological oscillatory activity within brain networks, is among the major theories of its mechanism. However, there remain fundamental questions on mechanisms, optimal targets and parameters that need to be better understood to improve this therapy and provide more individualized treatment according to the patient’s predominant symptoms.

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Brain Electrical Activity After Acute Hippocampal Stimulation in Awake Rats

Cited by 3 publications

References 11 publications

c-FOS Expression After Hippocampal Deep Brain Stimulation in Normal Rats

c-FOS Expression After Hippocampal Deep Brain Stimulation in Normal Rats

Control of epileptic seizures by electrical stimulation: a model-based study

Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders

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