Brain dopamine as a target for solvent toxicity: Effects of some monocyclic aromatic hydrocarbons

Mutti, Antonio; Falzoi, M; Romanelli, Alessandro; Bocchi, M. C.; Ferroni, C.; Franchini, I

doi:10.1016/0300-483x(88)90177-1

Cited by 59 publications

(22 citation statements)

References 8 publications

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“…[8][9][10] In addition, an investigation by Mutti et al showed that styrene exposure to rabbits resulted in a marked dose-dependent decrease in the striatal dopamine (DA) concentration. 11,12) Moreover, a similar effect was also described when phenylglyoxylic acid (PGA) and phenylglycine (PG), important metabolites of styrene, were administered. 13) These results suggested that the DA metabolism may be a target for the neurotoxic effect of styrene and its metabolites.…”

Section: Introductionmentioning

confidence: 77%

Changes in Middle Latency Auditory-Evoked Potentials of the Rat Exposed to Styrene.

Wang

Saito

Hosokawa

et al. 2001

JOURNAL OF HEALTH SCIENCE

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Effects of styrene exposure on middle latency auditory-evoked potentials (MAEPs), which reflect the central auditory function, were investigated. As significant delay in latencies of No, Po, Na, and Pa components and increases in the peak to peak intervals of MAEPs, but not amplitudes, were observed in a dose-dependent manner. The present and our previous studies demonstrate that electrophysiological alterations occur before neuronal cell damage induced by styrene exposure. The present results suggested that styrene has a marked effect on the processing of auditory information related to MAEPs.

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Section: Introductionmentioning

confidence: 77%

Changes in Middle Latency Auditory-Evoked Potentials of the Rat Exposed to Styrene.

Wang

Saito

Hosokawa

et al. 2001

JOURNAL OF HEALTH SCIENCE

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“…또한 이들 물질의 변화는 중추신경계의 기능저하 와 손상을 일으켜 대사증후군 유발에도 영향을 미친 다 (Husain et al, 1980;Gillis, Gavin, Arbieva, King, Jayaraman et al, 2007;Mutti et al, 1988 (Baek et al, 1996), 용접흄 흡입노출 영장류에서 Fpg/Endo 3 FLARE Assay를 이용한 DNA 손상 및 회복 (Rim et al, 2007), 방수 스 프레이 흡입 노출로 인한 급성 호흡기 중독 사례 및 원인 고찰 (Park & Choi, 2012), Buthanethiol의 물리 화학적 특성과 유해성 연구 (Kim et al, 2013), 흡입노 출 경로에 따른 설치류의 글루탈알데히드 독성영향 …”

Section: 서 론unclassified

Association of Exposure to Chemicals with Dyspnea among Employed Workers: Analysis of the 3^rdKorean Working Conditions Survey

Park¹,

Hwang²,

Hong³

et al. 2016

Journal of Korean Society of Occupational and Environmental Hyg

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Objectives: The purpose of this study was to investigate whether chemical exposure among workers has relevance to dyspnea using data from the 3 rd Korea Working Conditions Survey. Methods: The research subjects were 29,711 wage workers. Chemical exposures consist of four factors, (1) breathing in vapors, fumes, dust and dirt, (2) breathing in organic solvent vapors, (3) handling or touching chemicals, and (4) secondhand smoke. Multiple logistic regression analysis was performed to examine the association between chemical exposure and dyspnea in the last 12months using proc surveylogistic in SAS 9.3 statistical software excluding people who had received a diagnosis of hypertension or obesity that can affect the respiratory distress symptoms(n=27,842). Results: Chemical exposure among workers was associated with dyspnea after adjustment for demographics and job characteristics. Prevalence of dyspnea was 4.9 per 1,000 among men and 5.8 per 1,000. Compared to a total score of 0 points of chemical exposure among workers, a total score of 1, 2-3, and 4 points tended to have increased risk of dyspnea in a dose-response manner for both men (OR=1.43, 1.93, and 4.26; P-for trend=0.002) and women(OR=1.10, 2.81, and 7.70; P-for trend=0.002). Stratified analysis by duration of current job showed that the association between chemical exposure and dyspnea tended to get stronger until 15 years and then disappeared afterwards, which reflects healthy worker survivor effect. Conclusions: We observed significant association between chemical exposure and dyspnea using the data of the 3 rd Korea Working Conditions Survey. Our results warrants providing knowledge related to chemical exposure, performing prevention activities, and creating various health policies to protect workers. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License(http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…A large variety of studies in animals (Mutti et al, 1988;Von Euler et al, 1991 and humans (Edling et al, 1997) have demonstrated that repeated volatile organic compound exposure have deleterious effects on the dopaminergic system. The most ubiquitous volatile organic compound is formaldehyde (Form).…”

Section: Environmental Neurotoxicants and Drug Abusementioning

confidence: 99%

Interaction Between Exposure to Neurotoxicants and Drug Abuse

Carvajal¹,

Sanchez-Amate²,

Lerma-Cabrera³

et al. 2012

Environmental Health - Emerging Issues and Practice

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Brain dopamine as a target for solvent toxicity: Effects of some monocyclic aromatic hydrocarbons

Cited by 59 publications

References 8 publications

Changes in Middle Latency Auditory-Evoked Potentials of the Rat Exposed to Styrene.

Changes in Middle Latency Auditory-Evoked Potentials of the Rat Exposed to Styrene.

Association of Exposure to Chemicals with Dyspnea among Employed Workers: Analysis of the 3^rdKorean Working Conditions Survey

Interaction Between Exposure to Neurotoxicants and Drug Abuse

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Brain dopamine as a target for solvent toxicity: Effects of some monocyclic aromatic hydrocarbons

Cited by 59 publications

References 8 publications

Changes in Middle Latency Auditory-Evoked Potentials of the Rat Exposed to Styrene.

Changes in Middle Latency Auditory-Evoked Potentials of the Rat Exposed to Styrene.

Association of Exposure to Chemicals with Dyspnea among Employed Workers: Analysis of the 3rdKorean Working Conditions Survey

Interaction Between Exposure to Neurotoxicants and Drug Abuse

Contact Info

Product

Resources

About

Association of Exposure to Chemicals with Dyspnea among Employed Workers: Analysis of the 3^rdKorean Working Conditions Survey