Brain diffusion alterations in patients with COVID-19 pathology and neurological manifestations

Caroli, Anna; Capelli, Serena; Napolitano, Angela; Cabrini, Giulia; Arrigoni, Alberto; Pezzetti, Giulio; Previtali, Mattia; Longhi, Luca; Zangari, Rosalia; Lorini, Ferdinando Luca; Sessa, Maria; Remuzzi, Andrea; Gerevini, Simonetta

doi:10.1016/j.nicl.2023.103338

Cited by 19 publications

(11 citation statements)

References 41 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent multimodal MRI study on 86 PCC patients who on average were infected 11 months earlier (33% previously hospitalised) found reduced resting state functional connectivity between the left and right parahippocampal regions, as well as between bilateral OFC and the cerebellum, and functional connectivity changes in OFC were associated with memory performance [ 75 ]. Cognitive deficits including in executive functions were also found to be associated with grey matter atrophy in these areas [ 35 , 75 ] and white matter changes [ 28 , 71 , 73 ]. Besides single brain areas, the impact of multiple white matter hyperintensities observed in some COVID-19 patients can also contribute to their cognitive deficits in executive functions, processing speed, and memory [ 28 ].…”

Section: Neuroimagingmentioning

confidence: 99%

Effects of COVID-19 on cognition and brain health

Zhao,

Toniolo,

Hampshire

et al. 2023

Trends in Cognitive Sciences

View full text Add to dashboard Cite

Section: Neuroimagingmentioning

confidence: 99%

Effects of COVID-19 on cognition and brain health

Zhao,

Toniolo,

Hampshire

et al. 2023

Trends in Cognitive Sciences

View full text Add to dashboard Cite

“…However, with the recovery of symptoms, taste and smell symptoms gradually became a hot topic, and even led to the rise of the whole otolaryngological symptoms in the proportion of all symptoms. Given the context in which we nd that users refer to "smell taste" as "loss of smell taste" 25 , we can speculate that "smell taste" may be a convalescent symptom or sequel, like "cough. "…”

Section: Symptom Analysesmentioning

confidence: 99%

Social media can predict the COVID-19 epidemic in China

Liu,

Ma,

et al. 2023

Preprint

View full text Add to dashboard Cite

Background：To investigate whether social media data can predict the prevalence of the COVID-19 epidemic and to compare the differences between the information on COVID-19 reflected in social media and the officially published information. Methods：The Severe acute respiratory syndrome coronavirus 2 related data from Microblog (Sina Weibo) from November 30 to December 31，2022 were collected using a Weibo crawler with a total of 598,285 entries. Text clustering, spatio-temporal analysis and sentiment analysis were used to explore hot topics of public interest and describe COVID-19 related information in China. Result：The COVID-19 outbreak in China in December 2022 can be divided into four phases, with peak symptoms occurring from December 13 to December 28 and peak symptom frequency on December 15. Shanghai was less concerned with COVID-19 information, while Beijing was the first province to experience a peak in fever symptoms. Guangdong, the first province to have a liberalized outbreak, had a later peak of fever, and Sichuan had the most discussion about fever symptoms. It is thought that the infection spread from the central and western provinces and some northern provinces to surrounding areas. In late December, national concern about respiratory symptoms decreased, instead, discussion of ear, nose, and throat and systemic symptoms increased. The general emotion of the population was positive. Conclusion：Social media can predict the COVID-19 epidemic in China. The peak of COVID-19 symptoms in China in December 2022 was on December 15, one week before the peak of the officially confirmed data.

show abstract

“…Other studies demonstrated that TSPO PET is able to quantify (neuro)inflammation in multiple sclerosis, Alzheimer’s disease, rheumatoid arthritis29–31 and chronic fatigue 32. Involvement of the brain has also been shown by longitudinal MRI studies in subjects with SARS-CoV-2 infection where modest structural and microstructural differences were seen compared with subjects who were not infected 33–36. Moreover, research with (functional) MRI (fMRI) of the brain in other groups of patients with persistent fatigue and cognitive complaints, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis, have shown grey matter abnormalities,37 38 reduced functional connectivity39–41 and altered neuronal activity during cognitive tasks 42…”

Section: Introductionmentioning

confidence: 99%

Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case–control study (VeCosCO)

Verveen,

Verfaillie,

Visser

et al. 2023

BMJ Open

View full text Add to dashboard Cite

IntroductionThe risk factors for persistent fatigue and cognitive complaints after infection with SARS-CoV-2 and the underlying pathophysiology are largely unknown. Both clinical factors and cognitive-behavioural factors have been suggested to play a role in the perpetuation of complaints. A neurobiological aetiology, such as neuroinflammation, could be the underlying pathophysiological mechanism for persisting complaints.To unravel factors associated with persisting complaints, VeCosCO will compare individuals with and without persistent fatigue and cognitive complaints >3 months after infection with SARS-CoV-2. The study consists of two work packages. The first work package aims to (1) investigate the relation between persisting complaints and neuropsychological functioning; (2) determine risk factors and at-risk phenotypes for the development of persistent fatigue and cognitive complaints, including the presence of postexertional malaise and (3) describe consequences of persistent complaints on quality of life, healthcare consumption and physical functioning. The second work package aims to (1) determine the presence of neuroinflammation with [18F]DPA-714 whole-body positron emission tomography (PET) scans in patients with persisting complaints and (2) explore the relationship between (neuro)inflammation and brain structure and functioning measured with MRI.Methods and analysisThis is a prospective case–control study in participants with and without persistent fatigue and cognitive complaints, >3 months after laboratory-confirmed SARS-CoV-2 infection. Participants will be mainly included from existing COVID-19 cohorts in the Netherlands covering the full spectrum of COVID-19 acute disease severity. Primary outcomes are neuropsychological functioning, postexertional malaise, neuroinflammation measured using [18F]DPA-714 PET, and brain functioning and structure using (f)MRI.Ethics and disseminationWork package 1 (NL79575.018.21) and 2 (NL77033.029.21) were approved by the medical ethical review board of the Amsterdam University Medical Centers (The Netherlands). Informed consent is required prior to participation in the study. Results of this study will be submitted for publication in peer-reviewed journals and shared with the key population.

show abstract

Brain diffusion alterations in patients with COVID-19 pathology and neurological manifestations

Cited by 19 publications

References 41 publications

Effects of COVID-19 on cognition and brain health

Effects of COVID-19 on cognition and brain health

Social media can predict the COVID-19 epidemic in China

Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case–control study (VeCosCO)

Contact Info

Product

Resources

About