Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder

Dell’Osso, Liliana; Carmassi, Claudia; Debbio, Alessandro Del; Dell’Osso, Mario Catena; Bianchi, Carolina; Pozzo, Eleonora Da; Origlia, Nicola; Domenici, Luciano; Massimetti, Gabriele; Marazziti, Donatella; Piccinni, Armando

doi:10.1016/j.pnpbp.2009.04.018

Cited by 127 publications

(80 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results differ from those of Dell'osso et al [9] who reported lower BDNF plasma levels in PTSD. Looking at serum BDNF from another standpoint in the treatment of PTSD, no change was reported in BDNF levels during 12 weeks of escitalopram monotherapy, despite a substantial improvement in PTSD symptoms [24].…”

Section: Discussioncontrasting

confidence: 99%

“…In a consecutive sample of 34 patients with ASD or PTSD, they also found that patients recently exposed to trauma had higher serum BDNF levels than matched controls [8]. In contrast, Dell'osso et al [9] found lower plasma BDNF levels in 18 drug-free PTSD patients than in matched controls, and Bergeret al [10] reported that low serum BDNF levels over the course of a trial for escitalopram was predictive of a higher recovery rate from PTSD symptoms.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Longitudinal Changes in Serum Brain-Derived Neurotrophic Factor in Accident Survivors with Posttraumatic Stress Disorder

Matsuoka¹,

Nishi²,

Noguchi³

et al. 2013

Neuropsychobiology

View full text Add to dashboard Cite

Background: This prospective cohort study investigated the serum levels of brain-derived neurotrophic factor (BDNF), which mediates synaptic plasticity crucial for fear memory extinction, in patients severely injured in motor vehicle accidents (MVAs). Method: A nested, case-controlled study was conducted with 103 MVA survivors: 8 medication-naïve patients who met the criteria for full diagnosis of posttraumatic stress disorder (PTSD) at 6 months after MVA, 10 medication-naïve patients with partial PTSD and 85 patients with no PTSD. PTSD was evaluated by the Clinician-Administered PTSD Scale (CAPS). Serum BDNF levels were measured shortly after the MVA (baseline) and at 6-month follow-up. Results: Posttrauma serum BDNF levels differed between the 3 groups after controlling for age and sex (F = 3.41, p = 0.04), with unexpectedly higher serum BDNF levels seen in the full-PTSD group compared with the no-PTSD group. Additional analysis of patients with serum samples taken at baseline and at 6 months revealed the full-PTSD group had significantly higher serum BDNF levels over the 6 months than the no-PTSD group after controlling for age and sex (F = 6.44, p < 0.01). A positive correlation was seen between changes in serum BDNF levels over 6 months and the CAPS score at 6 months (r = 0.26, p = 0.014). Conclusions: The findings of this study, the first to report longitudinal serum BDNF levels in MVA survivors, suggest that elevated serum BDNF levels could be a biomarker of PTSD after a traumatic event.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Longitudinal Changes in Serum Brain-Derived Neurotrophic Factor in Accident Survivors with Posttraumatic Stress Disorder

Matsuoka¹,

Nishi²,

Noguchi³

et al. 2013

Neuropsychobiology

View full text Add to dashboard Cite

show abstract

“…However, such BDNF changes do not appear to be depression-specific, as they have been described in other psychiatric illnesses [22][23][24] and generally interpreted as a state-dependent marker or an index of stress [10] . Alternatively, BDNF changes in depression have been linked to clinical characteristics, such as severity of the illness [11] , or presence of psychotic symptoms [15] .…”

Section: Introductionmentioning

confidence: 99%

Associations between Brain-Derived Neurotrophic Factor Plasma Levels and Severity of the Illness, Recurrence and Symptoms in Depressed Patients

et al. 2010

Self Cite

View full text Add to dashboard Cite

Background: There is increasing evidence that the brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of mood disorders and that its peripheral levels represent a reliable mirror of its concentration in the brain. The aim of the present study was to measure BDNF plasma levels in patients affected by major depression and to explore the possible relationship between the biological parameter and characteristics of the illness. Method: BDNF plasma levels were evaluated in 30 inpatients suffering from major depression, according to DSM-IV criteria, by means of a commonly employed ELISA method. The clinical characteristics were assessed by the Hamilton Rating Scale for Depression (HRSD) and the Clinical Global Impression Scale. Results: BDNF plasma levels were significantly lower in the patients with the severest illness compared with the others, and the same was true for patients with dissociative symptoms, severe sleep disturbance and recurrent depression. A significant and negative correlation was observed between the biological parameter and the retardation factor score of the HRSD. Conclusion: These findings suggest that low BDNF levels are related to both recurrence and severity of depression, as well as to symptoms typical of dysfunctions of the hypothalamic-pituitary-adrenal axis.

show abstract

“…Low BDNF levels in PTSD patients have been reported in three studies. [12][13][14] In another study, 15 no association was found between changes in BDNF and PTSD, yet among the different traumatic events surveyed, sexual abuse had the strongest effect on reducing BDNF levels. Conversely, Hauck et al 16 and Matsuoka et al 17 showed that patients with recent trauma and PTSD had higher concentrations of BDNF.…”

Section: Introductionmentioning

confidence: 92%

Serum concentrations of brain-derived neurotrophic factor and mental disorders in imprisoned women

Dotta-Panichi

Bins

Tramontina

et al. 2015

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: Mental disorders and early trauma are highly prevalent in female inmates. Brain-derived neurotrophic factor (BDNF) plays an important role in learning, memory processes, and mood regulation. The aim of this study was to evaluate the relationship between serum BDNF levels and mental disorders among imprisoned women as compared with age-and education-matched controls. Methods: A consecutively recruited sample of 18 female prisoners with mental disorders was assessed for sociodemographic, criminal, and clinical variables using standardized instruments, the Mini International Neuropsychiatric Interview Plus (MINI Plus), and serum BDNF levels. Results: High rates of childhood sexual abuse and posttraumatic stress disorder (PTSD) were found in the group of forensic patients. Serum BDNF levels in the forensic group did not differ from those of healthy controls, and were significantly higher when compared with those of women with mental disorders hospitalized in a general hospital. Conclusion: Elevated serum BDNF levels were found in imprisoned women. The results of this study may suggest neurobiological mechanisms similar to those seen in previous clinical and preclinical studies showing the involvement of BDNF in the pathophysiology of PTSD.

show abstract

Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder

Cited by 127 publications

References 36 publications

Longitudinal Changes in Serum Brain-Derived Neurotrophic Factor in Accident Survivors with Posttraumatic Stress Disorder

Longitudinal Changes in Serum Brain-Derived Neurotrophic Factor in Accident Survivors with Posttraumatic Stress Disorder

Associations between Brain-Derived Neurotrophic Factor Plasma Levels and Severity of the Illness, Recurrence and Symptoms in Depressed Patients

Serum concentrations of brain-derived neurotrophic factor and mental disorders in imprisoned women

Contact Info

Product

Resources

About